In vivo evidence of complete circumvention of vincristine resistance by a new triazinoaminopiperidine derivative S 9788 in P388/VCR leukemia model

Cancer Chemotherapy and Pharmacology

Volumn 30, Issue 6, 1992, Pages 491-494

  Cros, Suzy ^a   Guilbaud, Nicolas ^b   Berlion, Maryse ^c   Dunn, Theresa ^c   Regnier, Gilbert ^b   Dhainaut, Alain ^b   Atassi, Ghanem ^b   Bizzari, Jean Pierre ^c  

^a CNRS   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 BIS(ALLYLAMINO) 6 [4 [[2,2 BIS(4 FLUOROPHENYL)ETHYL]AMINO]PIPERIDINO] 1,3,5 TRIAZINE; PIPERIDINE DERIVATIVE; VINCRISTINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; FEMALE; LEUKEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE; FEMALE; LEUKEMIA P388; MICE; MICE, INBRED STRAINS; PIPERIDINES; TRIAZINES; VINCRISTINE;

EID: 0026687878     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/BF00685604     Document Type: Article

References (18)

1. Mechanism of multidrug resistance
2. Expression of a multidrug resistance gene in human tumors and tissues
3. Pharmacology of drugs that alter multidrug resistance in cancer
4. Effect of verapamil on doxorubicin activity and pharmacokinetic in mice bearing resistant and solid tumors
5. Multidrug resistance and chemosensitization: therapeutic implication for cancer chemotherapy
6. Isolation and expression of a complementary DNA that confers multidrug resistance
7. Multidrug resistance in human cancer
8. Essential features of P-glycoprotein pharmacophore as defined by a series of reserpine analogues that modulate multidrug resistance
9. P-Glycoprotein as a target for chemosensitizing agents
10. Circumvention of Multidrug Resistance by a newly synthesised Quinoline derivative, MS-073
11. In vivo circumvention of vencristine resistance in mice with P388 leukemia using a novel compound, AHC-52
12. The location of multidrug resistance gene-product P-glycoprotein in normal tissues
13. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
14. Cure of mice bearing P388 leukemia by vincristine in combination with calcium channel blocker
15. Expression of a full length cDNA for the human mdr1 gene confers resistance to colchicine, doxorubicin and vinblastine
16. Physical chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells