Synthesis and Biological Activity of trans-(±)-N-Methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-Oxide (RP 49356) and Analogues: A New Class of Potassium Channel Opener

Journal of Medicinal Chemistry

Volumn 35, Issue 20, 1992, Pages 3613-3624

  Brown, Thomas J ^a   Chapman, Robert F ^a   Cook, David C ^a   Hart, Terance W ^a   McLay, Iain M ^a   Jordan, Roy ^a   Mason, Jonathan S ^a   Palfreyman, Malcolm N ^a   Walsh, Roger J A ^a   Withnall, Michael T ^a   Aloup, Jean Claude ^a,b   Cavero, Icilio ^a,b   Farge, Daniel ^a,b   James, Claude ^a,b   Mondot, Serge ^a,b  

^a SANOFI   (France)

^b Centre de Recherche de Vitry   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANGINA PECTORIS AGENT; ANTIHYPERTENSIVE AGENT; APRIKALIM; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; PYRIDINE DERIVATIVE; SULFOXIDE; THIOAMIDE; THIOPYRAN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG SYNTHESIS; ENANTIOMER; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMAL; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DOGS; MALE; MOLECULAR CONFORMATION; PICOLINES; POTASSIUM CHANNELS; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0026686540     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00098a004     Document Type: Article

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