1-ß-d-arabinosylcytosine and 5-azacytidine induce internucleosomal DNA fragmentation and cell death in thymocytes

Immunopharmacology

Volumn 24, Issue 3, 1992, Pages 219-227

  Kizaki, Harutoshi ^a   Ohnishi, Yoshiaki ^a   Azuma, Yutaro ^a   Mizuno, Yoshio ^a   Ohsaka, Fumihiro ^b  

^a TOKYO DENTAL COLLEGE   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

5 Azacytidine; Apoptosis; Arabinosylcytosine; Thymocyte

Indexed keywords

6 METHYLTHIOINOSINE; AZACITIDINE; FLOXURIDINE; FLUOROURACIL; MERCAPTOPURINE; METHOTREXATE;

ANIMAL CELL; APOPTOSIS; ARTICLE; DNA DEGRADATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMAL; APHIDICOLIN; APOPTOSIS; AZACITIDINE; BENZAMIDES; CELL DIVISION; CELLS, CULTURED; CYCLOHEXIMIDE; CYTARABINE; DACTINOMYCIN; DNA; DNA DAMAGE; ISOQUINOLINES; MALE; MICE; MICE, INBRED BALB C; NUCLEOSIDES; NUCLEOSOMES; PHOSPHORYLATION; PIPERAZINES; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0026685693     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/0162-3109(92)90077-P     Document Type: Article

References (29)

1. Antimetabolites
2. Apoptosis: mode of cell death induced in T-cell leukemia lines by dexamethasone and other agents
3. Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthemia
4. Terminal erythroid differentiation in the K-562 cell line by 1-ß-d-arabinofuranosylcytosine: accompaniment by c-myc messenger RNA decrease
5. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death
6. Cytosine arabinoside kills postmitotic neurons in a fashion resembling trophic deprivation: evidence that a deoxycytidine-dependent process may be required for nerve growth factor signal transduction
7. Clinical trials of differentiation therapy; current trials and future prospects
8. Adenosine deaminase deficiency in two patients with severe impaired cellular immunity
9. Nucleoside-phosphorylase deficiency and in a child with severely defective T-cell immunity and normal B-cell immunity
10. Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-ß-d-arabinofuranosylcytosine
11. DNA repair under stress
12. Purine nucleoside metabolizing enzyme activities in mouse thymocytes at different stages of differentiation and maturation
13. Adenosine, deoxyadenosine and deoxyguanosine induce DNA cleavage in mouse thymocytes
14. Adenosine receptor-mediated accumulation of cyclicAMP-induced T-lymphocyte death through internucleosomal DNA cleavage
15. Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol ester
16. Molecular and cellular basis of chemically induced immunotoxicity
17. Programmed death of autoreactive thymocytes
18. Biochemistry of diseases of immunodevelopment
19. 2+-mediated endonuclease activation
20. Calcium-activated DNA fragmentation kills immature thymocytes
21. Agents that elevate cAMP stimulate DNA fragmentation in thymocytes
22. Effects of 1-ß-d-arabinosylcytosine on proto-oncogene expression in human U-937 cells
23. DNA methylation and gene function
24. Characterization of arabinosylguanine resistance in a lymphoid cell line
25. The thymus selects the useful neglects the useless and destroys the harmful
26. Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes
27. Cytosine arabinoside transport and metabolism in acute leukemia and T-cell lymphoblastic lymphoma
28. Radiation-induced interphase death of rat thymocytes is internally programmed (apoptosis)