In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

Archives of Biochemistry and Biophysics

Volumn 294, Issue 2, 1992, Pages 454-460

  Vincent, Styliani H ^a   Karanam, Bindhu V ^a   Painter, Susan K ^a   Chiu, Shuet Hing L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSS REACTING ANTIBODY; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; DRUG METABOLITE; ENZYME ANTIBODY; ERYTHROMYCIN; PROADIFEN; TACROLIMUS; TROLEANDOMYCIN;

ADULT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS REACTION; DRUG METABOLISM; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; LIVER METABOLISM; LIVER MICROSOME; MALE; METABOLIC INHIBITION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT;

ADULT; ANIMAL; ANTIBODIES; BIOTRANSFORMATION; CARBON RADIOISOTOPES; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; FEMALE; HUMAN; KINETICS; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; PROADIFEN; RABBITS; RATS; RATS, INBRED STRAINS; TACROLIMUS; TROLEANDOMYCIN;

ANIMALIA; ORYCTOLAGUS CUNICULUS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0026681640     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/0003-9861(92)90711-5     Document Type: Article

References (21)

1. Identification of an inducible form of cytochrome P-450 in human liver.