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Volumn 52, Issue 15, 1992, Pages 4082-4089

Prevention of Acute Chemotherapy-induced Death in Mice by Recombinant Human Interleukin 1: Protection from Hematological and Nonhematological Toxicities

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROETHYLNITROSOUREA; CISPLATIN; CYCLOPHOSPHAMIDE; FLUOROURACIL; INTERLEUKIN 1;

EID: 0026672643     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (25)

References (52)
  • 1
    • 0002837689 scopus 로고
    • Clinical pharmacology of cancer chemotherapy.
    • Im V. T. DeVita, Jr., S. Hellman, and S. A. Rosenberg (eds.)., Ed. 3, Philadelphia: J. B. Lippincott Co.
    • Chabner, B. A., and Myers, C. E. Clinical pharmacology of cancer chemotherapy. Im V. T. DeVita, Jr., S. Hellman, and S. A. Rosenberg (eds.). Cancer, Principles and Practice of Oncology, Ed. 3, pp. 349-395. Philadelphia: J. B. Lippincott Co., 1989.
    • (1989) Cancer, Principles and Practice of Oncology , pp. 349-395
    • Chabner, B.A.1    Myers, C.E.2
  • 3
    • 0023241741 scopus 로고
    • Response of drug sensitive and resistant L1210 leukemias to high-dose chemotherapy.
    • Griswold, D. P., Jr., Trader, M. W., Frei, E., Peters, W. P., Wolpert, M. K., and Laster, W. R., Jr. Response of drug sensitive and resistant L1210 leukemias to high-dose chemotherapy. Cancer Res., 47: 2323-2327, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 2323-2327
    • Griswold, D.P.1    Trader, M.W.2    Frei, E.3    Peters, W.P.4    Wolpert, M.K.5    Laster, W.R.6
  • 4
    • 0024417735 scopus 로고
    • Interleukin-1 and its receptor.
    • Dinarello, C. A. Interleukin-1 and its receptor. Crit. Rev. Immunol., 9:1-20, 1989.
    • (1989) Crit. Rev. Immunol. , vol.9 , pp. 1-20
    • Dinarello, C.A.1
  • 7
    • 0020960545 scopus 로고
    • Human interleukin 1: purification and properties.
    • Lachman, L. B. Human interleukin 1: purification and properties. Fed. Proc., 42: 2639-2645, 1985.
    • (1985) Fed. Proc. , vol.42 , pp. 2639-2645
    • Lachman, L.B.1
  • 8
    • 0024332722 scopus 로고
    • Role of interleukin-1 in hematopoiesis
    • Moore, A. S. Role of interleukin-1 in hematopoiesis. Immunol. Res., 8: 165-175, 1989.
    • (1989) Immunol. Res. , vol.8 , pp. 165-175
    • Moore, A.S.1
  • 10
    • 0022649840 scopus 로고
    • Interleukin I as a radioprotector
    • Neta, R., Douches, S., and Oppenheim, J. J. Interleukin I as a radioprotector. J. Immunol., 136: 2483-2485, 1986.
    • (1986) J. Immunol. , vol.136 , pp. 2483-2485
    • Neta, R.1    Douches, S.2    Oppenheim, J.J.3
  • 11
    • 0023905482 scopus 로고
    • Protective restorative and therapeutic properties of recombinant human IL-1 in rodent models
    • Castelli, M. P., Black, P. L., Schneider, M., Pennington, R., Abe, F., and Talmadge, J. E. Protective restorative and therapeutic properties of recombinant human IL-1 in rodent models. J. Immunol., 140: 3830-3837, 1988.
    • (1988) J. Immunol. , vol.140 , pp. 3830-3837
    • Castelli, M.P.1    Black, P.L.2    Schneider, M.3    Pennington, R.4    Abe, F.5    Talmadge, J.E.6
  • 12
    • 0025614618 scopus 로고
    • Chemoprotective effects of rhIL-la in normal and tumor bearing mice: protection from acute toxicity, hematological effects, development of late mortality and enhanced therapeutic efHcacy
    • Futami, H., Jansen, R., MacPhee, M. J., Keller, J., McCormick, K., Longo, D. L., Oppenheim, J. J., Ruscetti, F. W., and Wiltrout, R. H. Chemoprotective effects of rhIL-la in normal and tumor bearing mice: protection from acute toxicity, hematological effects, development of late mortality and enhanced therapeutic efHcacy. J. Immunol., 145:4121-4130, 1990.
    • (1990) J. Immunol. , vol.145 , pp. 4121-4130
    • Futami, H.1    Jansen, R.2    MacPhee, M.J.3    Keller, J.4    McCormick, K.5    Longo, D.L.6    Oppenheim, J.J.7    Ruscetti, F.W.8    Wiltrout, R.H.9
  • 13
    • 0023600013 scopus 로고
    • Synergy of interleukin 1 and granulocyte colony-stimulating factor in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice
    • Moore, M. A. S., and Warren, D. J. Synergy of interleukin 1 and granulocyte colony-stimulating factor in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice. Proc. Natl. Acad. Sci. USA, 84: 7134-7138, 1987.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 7134-7138
    • Moore, M.A.S.1    Warren, D.J.2
  • 14
    • 0025253851 scopus 로고
    • Biology of multifunctional cytokines IL-6 and related molecules (IL-1 and TNF)
    • Arika, S., Hirano, T., Toga, T., and Kishimoto, T. Biology of multifunctional cytokines IL-6 and related molecules (IL-1 and TNF). FASEB J., 4: 2860-2867, 1990.
    • (1990) FASEB J. , vol.4 , pp. 2860-2867
    • Arika, S.1    Hirano, T.2    Toga, T.3    Kishimoto, T.4
  • 15
    • 0023946662 scopus 로고
    • Multiple action of interleukin 6 within a cytokine network
    • Wong, C. G., and Clark, S. C. Multiple action of interleukin 6 within a cytokine network. Immunol. Today, 9: 137-141, 1990.
    • (1990) Immunol. Today , vol.9 , pp. 137-141
    • Wong, C.G.1    Clark, S.C.2
  • 16
    • 0025226107 scopus 로고
    • Biological and clinical aspects of interleukin 6
    • Hirano, T., Akira, S., Taga, T., and Kishimoto, T. Biological and clinical aspects of interleukin 6. Immunol. Today, 11:443-449, 1990.
    • (1990) Immunol. Today , vol.11 , pp. 443-449
    • Hirano, T.1    Akira, S.2    Taga, T.3    Kishimoto, T.4
  • 17
    • 0023789633 scopus 로고
    • Synergistic and overlapping activities of tumor necrosis factor a and IL-1
    • L4ist-Bamey, K., Homon, C. A., Faanes, R. B., and Merluzzi, V. J. Synergistic and overlapping activities of tumor necrosis factor a and IL-1. J. Immunol., 141: 527-530, 1988.
    • (1988) J. Immunol. , vol.141 , pp. 527-530
    • L4ist-Bamey, K.1    Homon, C.A.2    Faanes, R.B.3    Merluzzi, V.J.4
  • 18
    • 0023183271 scopus 로고
    • Interleukin 1 stimulates human endothelial cells to produce granulocyte-macroph-age colony-stimulating factor and granulocyte colony-stimulating factor
    • Broudly, V. C., Kanshansky, K., Harlan, J. M., and Adamson, J. W. Interleukin 1 stimulates human endothelial cells to produce granulocyte-macroph-age colony-stimulating factor and granulocyte colony-stimulating factor. J. Immunol., 139: 464-468, 1987.
    • (1987) J. Immunol. , vol.139 , pp. 464-468
    • Broudly, V.C.1    Kanshansky, K.2    Harlan, J.M.3    Adamson, J.W.4
  • 19
    • 0023717163 scopus 로고
    • Interleukin 1, tumor necrosis factor and the production of colony stimulating factors by cultured mesenchymal cells
    • Sieff, C. A., Niemeyer, C. M., Mentzer, S. J., and Faller, D. V. Interleukin 1, tumor necrosis factor and the production of colony stimulating factors by cultured mesenchymal cells. Blood, 72: 1316-1323, 1988.
    • (1988) Blood , vol.72 , pp. 1316-1323
    • Sieff, C.A.1    Niemeyer, C.M.2    Mentzer, S.J.3    Faller, D.V.4
  • 20
    • 0023878440 scopus 로고
    • Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors
    • Kanshansky, K., Lin, N., and Adamson, J. W. Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. J. Clin. Invest., 81: 92-97, 1988.
    • (1988) J. Clin. Invest. , vol.81 , pp. 92-97
    • Kanshansky, K.1    Lin, N.2    Adamson, J.W.3
  • 21
    • 0023118919 scopus 로고
    • Induction of colony stimulating factor in vivo by recombinant IL-1 a and recombinant TNFa
    • Vogel, S. N., Douches, S. D., Kaufman, E. N., and Neta, R. Induction of colony stimulating factor in vivo by recombinant IL-1 a and recombinant TNFa. J. Immunol., 138: 2143-2148, 1987.
    • (1987) J. Immunol. , vol.138 , pp. 2143-2148
    • Vogel, S.N.1    Douches, S.D.2    Kaufman, E.N.3    Neta, R.4
  • 22
    • 0024357546 scopus 로고
    • Endotoxin, tumor necrosis factor a and interleukin 1 induce interleukin 6 production in vivo
    • Shalaby, M. R., Waage, A., Aarden, L., and Espevik, T. Endotoxin, tumor necrosis factor a and interleukin 1 induce interleukin 6 production in vivo. Clin. Immunol. Immunopathol., 51: 488-498, 1989.
    • (1989) Clin. Immunol. Immunopathol. , vol.51 , pp. 488-498
    • Shalaby, M.R.1    Waage, A.2    Aarden, L.3    Espevik, T.4
  • 23
    • 0024603761 scopus 로고
    • Interleukin 1 and its Biologically related cytokines.
    • Dinarello, C. A. Interleukin 1 and its Biologically related cytokines. Adv. Immunol., 44: 153-205, 1989.
    • (1989) Adv. Immunol. , vol.44 , pp. 153-205
    • Dinarello, C.A.1
  • 24
    • 0025363657 scopus 로고
    • Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice
    • Libert, C., Brouckaert, P., Shaw, A., and Fiers, W. Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice. Eur. J. Immunol., 20:691-694, 1990.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 691-694
    • Libert, C.1    Brouckaert, P.2    Shaw, A.3    Fiers, W.4
  • 25
    • 0022442486 scopus 로고
    • Production of tumor necrosis factor in unprimed mice: mechanism of endotoxin-mediated tumor necrosis
    • Flick, D. A., and Gifford, G. E. Production of tumor necrosis factor in unprimed mice: mechanism of endotoxin-mediated tumor necrosis. ImmunoBiology, 171: 320-328, 1986.
    • (1986) ImmunoBiology , vol.171 , pp. 320-328
    • Flick, D.A.1    Gifford, G.E.2
  • 26
    • 0023182058 scopus 로고
    • Cytokine-dependent granulocytic differentiation: regulation of proliferative and differentiative responses in a murine progenitor cell line
    • Valiteri, M., Tweardy, D. J., Caracciolo, D., Johnson, K., Mavilio, F., Alt-mann. S., Santoli, D., and Rovera, G. Cytokine-dependent granulocytic differentiation: regulation of proliferative and differentiative responses in a murine progenitor cell line. J. Immunol., 138: 3829-3835, 1987.
    • (1987) J. Immunol. , vol.138 , pp. 3829-3835
    • Valiteri, M.1    Tweardy, D.J.2    Caracciolo, D.3    Johnson, K.4    Mavilio, F.5    Alt-mann, S.6    Santoli, D.7    Rovera, G.8
  • 27
    • 0025733853 scopus 로고
    • The involvement of TNF, IL-1 and IL-6 in the immune response to protozoan parasites
    • Tiris, R. G., Sherry, B., and Ceramy, A. The involvement of TNF, IL-1 and IL-6 in the immune response to protozoan parasites. Immunol. Today, 12: A13-A16, 1991.
    • (1991) Immunol. Today , vol.12 , pp. A13-A16
    • Tiris, R.G.1    Sherry, B.2    Ceramy, A.3
  • 28
    • 0017674286 scopus 로고
    • Bone marrow transplantation after lethal chemotherapy in “nude mice
    • Stinner, G., and Floersheim, G. L. Bone marrow transplantation after lethal chemotherapy in “nude mice.” Transplantation (Baltimore), 24: 218-222, 1977.
    • (1977) Transplantation (Baltimore) , vol.24 , pp. 218-222
    • Stinner, G.1    Floersheim, G.L.2
  • 30
    • 0024347920 scopus 로고
    • Preclinical and clinical studies with the hematopoietic colony stimulating factors and related interleukins
    • Broxmeyer, H. E., and Vadhan-Raj, S. Preclinical and clinical studies with the hematopoietic colony stimulating factors and related interleukins. Immunol. Res., 8: 185-201, 1989.
    • (1989) Immunol. Res. , vol.8 , pp. 185-201
    • Broxmeyer, H.E.1    Vadhan-Raj, S.2
  • 32
    • 0021048258 scopus 로고
    • Phase II study of JM8 a new platinum analog in advanced ovarian carcinoma
    • Evans, B. D., Rajn, K. S., Calvert, A. H., Harland, S. J., and Wiltshaw, E. Phase II study of JM8 a new platinum analog in advanced ovarian carcinoma. Cancer Treat. Rep., 67:997-1000, 1984.
    • (1984) Cancer Treat. Rep. , vol.67 , pp. 997-1000
    • Evans, B.D.1    Rajn, K.S.2    Calvert, A.H.3    Harland, S.J.4    Wiltshaw, E.5
  • 33
    • 0025293049 scopus 로고
    • Interleukin 6 perfusion stimulates reconstitution of the immune and hematopoietic systems after 5-fluorouracil treatment
    • Takatsuki, F., Okano, A., Suzuki, C., Miyasaka, V., Hirano, T., Kishimoto, T., Ejima, D., and Akiyama, Y. Interleukin 6 perfusion stimulates reconstitution of the immune and hematopoietic systems after 5-fluorouracil treatment. Canccr Res., 50: 2885-2890, 1990.
    • (1990) Canccr Res. , vol.50 , pp. 2885-2890
    • Takatsuki, F.1    Okano, A.2    Suzuki, C.3    Miyasaka, V.4    Hirano, T.5    Kishimoto, T.6    Ejima, D.7    Akiyama, Y.8
  • 36
    • 0024313179 scopus 로고
    • A single low dose of human recombinant interleukin 1 accelerates the recovery of neutrophils in mice with cyclophosphamide-induced neutropenia
    • Fibbe, W. E., Van der Meer, J. W. M., Frederik Falkenburg, J. H., Hamilton, M. S., Kluin-Neleman, J. C., and Dinarello, C. A single low dose of human recombinant interleukin 1 accelerates the recovery of neutrophils in mice with cyclophosphamide-induced neutropenia. Exp. Hematol., 17: 805-808, 1989.
    • (1989) Exp. Hematol. , vol.17 , pp. 805-808
    • Fibbe, W.E.1    Van der Meer, J.W.M.2    Frederik Falkenburg, J.H.3    Hamilton, M.S.4    Kluin-Neleman, J.C.5    Dinarello, C.6
  • 38
    • 0024374658 scopus 로고
    • Prevention of doxorubicin-induced hematotoxicity in mice with interleukin I
    • Eppstein, D. A., Kurakara, C. G., Bruno, N. A., and Ferrell, T. G. Prevention of doxorubicin-induced hematotoxicity in mice with interleukin I. Cancer Res., 49: 3955-3960, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 3955-3960
    • Eppstein, D.A.1    Kurakara, C.G.2    Bruno, N.A.3    Ferrell, T.G.4
  • 39
    • 0025234624 scopus 로고
    • Regulation of hemopoiesis by bone marrow stromal cells and their products.
    • Dorshkind, K. Regulation of hemopoiesis by bone marrow stromal cells and their products. Annu. Rev. Immunol., 8: 111-137, 1990.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 111-137
    • Dorshkind, K.1
  • 40
    • 0016257397 scopus 로고
    • Cardiac and pulmonary effects of high doses of cyclophosphamide and isophosphamide.
    • O'Connell, T. X., and Berenbaum, M. C. Cardiac and pulmonary effects of high doses of cyclophosphamide and isophosphamide. Cancer Res., 34: 1568-1591, 1974.
    • (1974) Cancer Res. , vol.34 , pp. 1568-1591
    • O'Connell, T.X.1    Berenbaum, M.C.2
  • 41
    • 0014192259 scopus 로고
    • Immunological tolerance induced by cyclophosphamide assayed by plaque spleen cell method
    • Aisenberg, A. C., and Wilkes, B. Immunological tolerance induced by cyclophosphamide assayed by plaque spleen cell method. Nature (Lond.), 213: 498-499, 1967.
    • (1967) Nature (Lond.) , vol.213 , pp. 498-499
    • Aisenberg, A.C.1    Wilkes, B.2
  • 42
    • 0023252028 scopus 로고
    • Enhanced resistance of mice to bacterial infection induced by recombinant human interleukin-la
    • Ozaki, Y., Ohashi, T., Minami, A., and Nakamura, S. Enhanced resistance of mice to bacterial infection induced by recombinant human interleukin-la. Infect. Immun., 55: 1436-1440, 1987.
    • (1987) Infect. Immun. , vol.55 , pp. 1436-1440
    • Ozaki, Y.1    Ohashi, T.2    Minami, A.3    Nakamura, S.4
  • 43
    • 0023878325 scopus 로고
    • A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection
    • Mier, J. W. M., Barza, M., Wolff, S. M., and Dinarello, C. A. A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection. Proc. Natl. Acad. Sci. USA, 85: 1620-1623, 1988.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 1620-1623
    • Mier, J.W.M.1    Barza, M.2    Wolff, S.M.3    Dinarello, C.A.4
  • 44
    • 0025212264 scopus 로고
    • Prevention of fatal infections by recombinant interleukin la in normal and anticancer drug-treated mice
    • Moritage, T., Mizushima, Y., Sakamoto, K., and Yano, S. Prevention of fatal infections by recombinant interleukin la in normal and anticancer drug-treated mice. Cancer Res., 50: 2099-2104, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 2099-2104
    • Moritage, T.1    Mizushima, Y.2    Sakamoto, K.3    Yano, S.4
  • 45
    • 0023709264 scopus 로고
    • Augmentation of host resistance to microbial infections by recombinant human interleukin la
    • Minami, A., Fujimoto, K., Ozaki, Y., and Nakamura, S. Augmentation of host resistance to microbial infections by recombinant human interleukin la. Infect. Immun., 56: 3116-3120, 1988.
    • (1988) Infect. Immun. , vol.56 , pp. 3116-3120
    • Minami, A.1    Fujimoto, K.2    Ozaki, Y.3    Nakamura, S.4
  • 46
    • 0023432812 scopus 로고
    • Interferon ß2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the miyor acute phase protein response in liver cells
    • Gauldie, J., Richards, C., Hamish, D., Landsdorp, P., and Baumann, H. Interferon ß2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the miyor acute phase protein response in liver cells. Proc. Natl. Acad. Sci. USA, 84: 7251-7255, 1987.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 7251-7255
    • Gauldie, J.1    Richards, C.2    Hamish, D.3    Landsdorp, P.4    Baumann, H.5
  • 47
    • 0022572130 scopus 로고
    • The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-7
    • Broxmeyer, H. E., Williams, D. E., Lu, L., Cooper, S., Anderson, S. L., Beyer, G. S., Hoffman, R., and Rubin, B. Y. The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-7. J. Immunol., 136: 4487-4495, 1986.
    • (1986) J. Immunol. , vol.136 , pp. 4487-4495
    • Broxmeyer, H.E.1    Williams, D.E.2    Lu, L.3    Cooper, S.4    Anderson, S.L.5    Beyer, G.S.6    Hoffman, R.7    Rubin, B.Y.8
  • 48
    • 0023141312 scopus 로고
    • Effect of recombinant human tumor necrosis factor on the colony growth of human leukemia progenitor cells and normal hematopoietic progenitor cells
    • Murase, T., Holla, T., Saito, H., and Ohno, K. Effect of recombinant human tumor necrosis factor on the colony growth of human leukemia progenitor cells and normal hematopoietic progenitor cells. Blood, 69:467-472, 1987.
    • (1987) Blood , vol.69 , pp. 467-472
    • Murase, T.1    Holla, T.2    Saito, H.3    Ohno, K.4
  • 49
    • 0342415272 scopus 로고
    • Lymphokine regulation of hematopoietic cell development.
    • In: J. J. Oppenheim and E. M. Shevach (eds.), New York: Oxford University Press
    • Ihle, J. H. Lymphokine regulation of hematopoietic cell development. In: J. J. Oppenheim and E. M. Shevach (eds.), Immunophysiology, pp. 166-193. New York: Oxford University Press, 1990.
    • (1990) Immunophysiology , pp. 166-193
    • Ihle, J.H.1
  • 50
    • 0025720098 scopus 로고
    • In vivo interleukin 1 (IL-1) administration indirectly promotes type IIIL-I receptor expression on hematopoietic bone marrow cells: novel mechanism for the hematopoietic effects of IL-I
    • Dubois, C. M., Ruscetti, F. W., Keller, J. R., Oppenheim, J. J., Hestdal, K., Chizzonite, R., and Neta, R. In vivo interleukin 1 (IL-1) administration indirectly promotes type IIIL-I receptor expression on hematopoietic bone marrow cells: novel mechanism for the hematopoietic effects of IL-I. Blood, 78: 2841-2847, 1992.
    • (1992) Blood , vol.78 , pp. 2841-2847
    • Dubois, C.M.1    Ruscetti, F.W.2    Keller, J.R.3    Oppenheim, J.J.4    Hestdal, K.5    Chizzonite, R.6    Neta, R.7
  • 51
    • 0023648411 scopus 로고
    • Current concepts: lymphokines
    • Dinarello, C. A., and Mier, J. W. Current concepts: lymphokines. N. Engl. J. Med., 317: 940-945, 1987.
    • (1987) N. Engl. J. Med. , vol.317 , pp. 940-945
    • Dinarello, C.A.1    Mier, J.W.2
  • 52
    • 0025021471 scopus 로고
    • Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist
    • Eisenberg, S. P., Evans, R. J., Arend, W. P., Verderber, E., Brewer, M. T., Hannum, C. H., and Thompson, R. C. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature (Lond.), 343: 341-346, 1990.
    • (1990) Nature (Lond.) , vol.343 , pp. 341-346
    • Eisenberg, S.P.1    Evans, R.J.2    Arend, W.P.3    Verderber, E.4    Brewer, M.T.5    Hannum, C.H.6    Thompson, R.C.7


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