Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

Cell

Volumn 70, Issue 5, 1992, Pages 751-763

  Appleby, Mark W ^a   Gross, Jane A ^a   Cooke, Michael P ^a   Levin, Steven D ^a   Qian, Xuan ^a   Perlmutter, Roger M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; ANTIGEN; MITOGENIC AGENT; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; BRAIN; CALCIUM TRANSPORT; FLOW CYTOMETRY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LYMPHOCYTE ACTIVATION; MOUSE; MUTATION; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN; SPLEEN CELL; T LYMPHOCYTE; THYMOCYTE; THYMUS;

ANIMAL; BASE SEQUENCE; CALCIUM; CELLS, CULTURED; LYMPHOCYTE ACTIVATION; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SPLEEN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THYMUS GLAND;

EID: 0026669001     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(92)90309-Z     Document Type: Article

References (44)

1. lck
2. lck
3. lck
4. lck that phosphorylates the CD3 complex
5. The role of the T cell receptor in positive and negative selection of developing T cells
6. Production and analysis of chimaeric mice
7. Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases
8. Single step method of RNA isolation by acid guanidinium-thiocyanate-phenol-chloroform extraction
9. Expression of a novel form of the fyn proto-oncogene in hematopoietic cells
10. fyn
11. T-cell development and transmembrane signalling: changing biological responses through an unchanging receptor
12. Tyrphostines. I. Synthesis and biological activity of protein-tyrosine kinase inhibitors
13. lck: identification of novel intermolecular association
14. + thymocytes
15. T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates
16. Membrane glycoprotein IV (CD36) is physically associated with the fyn, lyn, and yes protein-tyrosine kinases in human platelets
17. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation
18. Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction
19. Simplified mammalian DNA isolation procedure
20. ε
21. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells a general strategy for targeting mutations to non-selectable genes
22. A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
23. lck
24. T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation
25. Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation: simultaneous use of indo-1 and immunofluorescence with flow cytometry
26. Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance
27. +CD8 thymocytes are functionally immature
28. Embryo-derived stem cell lines
29. The CD4 receptor is complexed to a T-cell specific tyrosine kinase (pp58) in detergent lysates from human T lymphocytes
30. Association of the fyn protein tyrosine kinase with the T cell antigen receptor
31. T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-γ1
32. The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique aminoterminal domain
33. Tyrosine phosphorylation is an obligatory event in IL-2 secretion
34. lyn mutant mice display differential signaling in thymoctyes and peripheral T cells
35. Fyn tyrosine kinase associated with FcqRll/CD23: possible multiple roles in lymphocyte activation
36. lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
37. lyn in T cell development
38. lck
39. lck
40. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules
41. The role of T3/antigen receptor complex in T cell activation
42. Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-γ1
43. The Vβ-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice
44. Signal transduction by the platelet derived growth factor receptor