Simultaneous assessment of insulin secretion and insulin sensitivity using a hyperglycemia clamp

Journal of Clinical Endocrinology and Metabolism

Volumn 75, Issue 2, 1992, Pages 379-382

  Mitrakou, A ^b   Vuorinen Markkola, H ^e   Mokan, M ^a,f   Toft, I ^c   Strumph, P ^a   Pimenta, W ^a   Veneman, T ^a   Jenssen, T ^c   Bolli, G ^d   Korytkowski, M ^a   Yki Jarvinen, H ^e   Gerich, J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^d UNIVERSITY OF PERUGIA   (Italy)

^e UNIVERSITY OF HELSINKI   (Finland)

^f Medical School of Komensky University ^*  (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ARTICLE; CLEARANCE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INFUSION; HUMAN; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN INFUSION; INSULIN RELEASE; INSULIN SENSITIVITY; MALE; OBESITY; PRIORITY JOURNAL; REPRODUCIBILITY;

BLOOD GLUCOSE; BODY MASS INDEX; COMPARATIVE STUDY; GLUCOSE CLAMP TECHNIQUE; HUMAN; INSULIN; INSULIN RESISTANCE; OBESITY; OSMOLAR CONCENTRATION; REFERENCE VALUES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026666403     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem.75.2.1639939     Document Type: Article

References (24)

1. Andres R, Swerdloff R, Pozefsky T, Coleman D. 1966 Manual feedback technique for the control of blood glucose concentration. In: Skeggs L, ed. Automation in analytical chemistry. White Plains: Mediad; 486-91.
2. DelPrato S, Ferrannini E, DeFronzo R. 1984 Evaluation of insulin sensitivity in man. In: Clark W, Lamer J, Pohl S, eds. Methods in diabetes research, volume II, clinical methods, New York: Wiley and Sons; 35-77.
3. Bergman R, Finegood D, Ader M. 1985 Assessment of insulin sensitivity in vivo. Endocr Rev. 6:45-86.
4. Rudenski A, Hosker J, Burnett M, Matthews D, Turner R. 1988 The β-cell glucose stimulus-response curve in normal humans assessed by insulin and C-peptide secretion rates. Metabolism. 37:526-34.
5. Eriksson J, Franssila-Kallunki A, Ekstand A, et al. 1989 Early metabolic defects in persons at increased risk for noninsulin-dependent diabetes mellitus. N Engl J Med. 321:337-43.
6. DeFronzo R. 1979 Glucose intolerance and aging: evidence for tissue insensitivity to insulin. Diabetes. 28:1095-101.
7. DelPrato S, Kreutzenberg S, Riccio A, et al. 1990 Partial recovery of insulin secretion and action after combined insulin-sulfonylurea treatment in type 2 (noninsulin-dependent) diabetic patients with secondary failure to oral agents. Diabetologia. 33:688-95.
8. Polonsky K, Given B, Hirsch L, et al. 1988 Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest. 81:435-41.
9. Bonadonna R, Groop L, Kraemer N, Ferrannini E, DelPrato S, DeFronzo R. 1990 Obesity and insulin resistance in human: a dose-response study. Metabolism. 39:452-9.
10. Gumbiner B, Polonsky K, Beltz W, Wallace P, Brechtei G, Fink R. 1989 Effects of aging on insulin secretion. Diabetes. 38:1549-56.
11. DeFronzo R, Tobin J, Andres R. 1979 Glucose clamp technique. A method for quantifying insulin secretion and resistance. Am J Physiol. 237:E214-22.
12. Diabetes mellitus. Technical report series 727. Geneva: WHO; 1985.
13. McGuire E, Helderman J, Tobin J, Andres R, Berman M. 1976 Effect of arterial versus venous sampling on analysis of glucose kinetics in man. J Appl Physiol. 41:565-73.
14. Rizza R, Mandarino L, Gerich J. 1981 Mechanism and significance of insulin resistance in noninsulin-dependent diabetes mellitus. Diabetes. 30:990-5.
15. Mitrakou A, Ryan C, Veneman T, et al. 1991 Hierarchy of thresholds for activation of counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol. 260:E67-74.
16. Campbell P, Mandarino L, Gerich J. 1988 Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in noninsulin-dependent diabetes mellitus. Metabolism. 37:15-22.
17. Verdonk C, Rizza R, Gerich J. 1981 Effects of plasma glucose concentration on glucose utilization and glucose clearance in normal man. Diabetes. 30:535-7.
18. Bergman R, Phillips J, Cobelli C. 1981 Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and B-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest. 68:1456-67.
19. Bergman R, Prager R, Volund A, Olesfsky J. 1987 Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest. 79:790-800.
20. Ferrari P, Alleman Y, Shaw S, Riesen W, Wiedmann P. 1991 Reproducibility of insulin sensitivity measured by the minimal model method. Diabetologia. 34:527-30.
21. Beard J, Bergman R, Ward K, Porte D. 1986 The insulin sensitivity index in nondiabetic man correlation between clamp-derived and IVGTT-derived values. Diabetes. 35:362-70.
22. Caumo A, Giacca A, Morgese M, Pozza G, Micossi P, Cobelli C. 1991 Minimal models of glucose disappearance: lessons from the labelled IVGTT. Diabetic Med. 8:822-32.
23. Yoshioka N, Kuzuya T, Matsuda A, Taniguchi M, Iwamoto Y. 1988 Serum proinsulin levels at fasting and after oral glucose loads in patients with type 2 (noninsulin-dependent) diabetes mellitus. Diabetologia. 31:355-60.
24. Temple R, Clark P, Naji D, Schneider A, Yudkin J, Hales C. 1990 Radioimmunoassay may overestimate insulin in noninsulin-dependent diabetes. Clin Endocrinol (Oxf). 32:689-93