The role of selenium in thyroid hormone action

Endocrine Reviews

Volumn 13, Issue 2, 1992, Pages 207-219

  Berry, Marla J ^a   Larsen, P Reed ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ELONGATION FACTOR; LIOTHYRONINE; SELENIUM; SELENOAMINO ACID; SELENOCYSTEINE; THYROID HORMONE; THYROXINE DEIODINASE; TRANSFER RNA;

ANIMAL CELL; BIOCHEMISTRY; CODON; CONGENITAL HYPOTHYROIDISM; DEIODINATION; DNA LIBRARY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; NUTRITION; OOCYTE; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; RNA TRANSCRIPTION; SELENIUM DEFICIENCY; THYROID HORMONE METABOLISM; XENOPUS;

ANIMAL; CLONING, MOLECULAR; CRETINISM; CYSTEINE; HUMAN; IODIDE PEROXIDASE; ORGANOSELENIUM COMPOUNDS; PROTEINS; SELENIUM; SELENOCYSTEINE; SUPPORT, U.S. GOV'T, P.H.S.; THYROID HORMONES;

EID: 0026665609     PISSN: 0163769X     EISSN: 0163769X     Source Type: Journal    
DOI: 10.1210/edrv-13-2-207     Document Type: Article

References (93)

1. Larsen PR, Silva JE, Kaplan MM 1981 Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications Endocr Rev 2:87
2. Leonard JL, Visser TJ 1986 Biochemistry of deiodination. In: Hennemann G (ed) Thyroid Hormone Metabolism. W. B. Saunders, Philadelphia, p 189
3. Gross J, Pitt-Rivers R 1952 The identification of 3,5,3’-L-triiodo-thyronine in human plasma. Lancet 1:439
4. Morreale de Escobar G, Escobar del Rey F 1967 Extrathyroidal effects of some antithyroid drugs and their metabolic consequences. Recent Prog Horm Res 23:87
5. Oppenheimer JH, Schwartz HL, Surks MI 1972 Propylthiouracil inhibits the conversion of L-thyroxine to L-triiodothyronine. An explanation of the antithyroxine effect of propylthiouracil and evidence supporting the concept that triiodothyronine is the active thyroid hormone. J Clin Invest 51:2493
6. 4) with biologic effects of thyroid hormone replacement in propylthiouracil-treated rats. Metabolism 24:547
7. Silva JE, Larsen PR 1977 Pituitary nuclear 3,5,3’-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine. Science 198:617
8. Silva JE, Dick TE, Larsen PR 1978 Contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3’-triiodothyronine in pituitary, liver, and kidney of euthyroid rats. Endocrinology 103:1196
9. Silva JE, Larsen PR 1978 Contributions of plasma triiodothyronine and local thyroxine monodeiodination to triiodothyronine to nuclear triiodothyronine receptor saturation in pituitary, liver, and kidney of hypothyroid rats. J Clin Invest 61:1247
10. Larsen PR, Dick TE, Markovitz BP, Kaplan MM, Gard TG 1979 Inhibition of intrapituitary thyroxine to 3,5,3’-triiodothyronine conversion prevents the acute suppression of thyrotropin release in hypothyroid rats. J Clin Invest 64:117
11. Obregon MJ, Pascual A, Mallol J, Morreale de Escobar G, Escobar Del Rey F 1980 Evidence against a major role of L-thyroxine at the pituitary level: studies in rats treated with iopanoic acid (Telepaque). Endocrinology 106:1827
12. Cheron RG, Kaplan MM, Larsen PR 1979 Physiological and pharmacological influences on thyroxine to 3,5,3’-triiodothyronine conversion and nuclear 3,5,3’-triiodothyronine binding in pituitary. J Clin Invest 64:1402
13. Silva JE, Leonard JL, Crantz FR, Larsen PR 1982 Evidence for two tissue-specific pathways for in vivo thyroxine 5’-deiodination in the rat. J Clin Invest 69:1176
14. Visser TJ, Kaplan MM, Leonard JL, Larsen PR 1983 Evidence for two pathways of iodothyronine 5’-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. J Clin Invest 71:992
15. Kaplan MM, Yaskoski KA 1980 Phenolic, tyrosyl ring deiodination of iodothyronines in rat brain homogenates. J Clin Invest 66:551
16. Visser TJ, Leonard JL, Kaplan MM, Larsen PR 1982 Kinetic evidence suggesting two mechanisms for iodothyronine 5’-deiodination in rat cerebral cortex. Proc Natl Acad Sci USA 79:5080
17. Silva JE, Larsen PR 1983 Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature 305:712
18. Leonard JL, Mellen SA, Larsen PR 1982 Thyroxine 5’-deiodinase activity in brown adipose tissue. Endocrinology 112:1153
19. Kaplan MM, Shaw EA 1984 Type II iodothyronine 5’-deiodination by human and rat placenta in vitro. J Clin Endocrinol Metab 59:253
20. Silva JE, Mellen SA, Larsen PR 1987 Comparison of kidney and brown adipose tissue iodothyronine 5’-deiodinases. Endocrinology 121:650
21. Leonard JL, Kaplan MM, Visser TJ, Silva JE, Larsen PR 1981 Cerebral cortex responds rapidly to thyroid hormones. Science 214:571
22. Silva JE, Gordon MB, Crantz FR, Leonard JL, Larsen PR 1984 Qualitative and quantitative differences in the pathways of extra-thyroidal triiodothyronine generation between euthyroid and hypothyroid rats. J Clin Invest 73:898
23. Goswami A, Rosenberg IN 1983 Stimulation of iodothyronine outer ring monodeiodinase by dihydrolipoamide. Endocrinology 112:1180
24. Goswami A, Rosenberg IN 1985 Purification and characterization of a cytosolic protein enhancing GSH-dependent microsomal iodothyronine 5’-monodeiodination. J Biol Chem 26:6012
25. Goswami A, Rosenberg IN 1987 Thioredoxin stimulates enzymatic outer ring monodeiodination of reverse triiodothyronine. Endocrinology 121:1937
26. Goswami A, Rosenberg IN 1988 Effects of glutathione on iodothyronine 5’-deiodinase activity. Endocrinology 123:192
27. Visser TJ, Van der Does-Tobe I, Docter R, Hennemann G. 1976 Subcellular localization of a rat liver enzyme converting thyroxine into tri-iodothyronine and possible involvement of essential thiol groups. Biochem J 157:479
28. Kaplan MM 1979 Changes in the particulate subcellular component of hepatic thyroxine-5’-monodeiodinase in hyperthyroid and hypothyroid rats. Endocrinology 105:548
29. Laurberg P 1978 Selective inhibition of triiodothyronines from the perfused canine thyroid by propylthiouracil. Endocrinology 103:900
30. Ishii H, Inada M, Tanaka K, Mashio Y, Naito K, Nishikawa M, Imura H 1981 Triiodothyronine generation from thyroxine in human thyroid: enhanced conversion in Graves’ thyroid tissue. J Clin Endocrinol Metab 52:1211
31. Erickson VJ, Cavalieri RR, Rosenberg LL 1982 Thyroxine-5’-deiodinase of rat thyroid, but not that of liver, is dependent on thryotropin. Endocrinology 111:434
32. Ishii H, Inada M, Tanaka K, Mashio Y, Naito K, Nishikawa M, Matsuzuka F, Kuma K, Imura H 1983 Induction of outer and inner ring monodeiodinases in human thyroid gland by thyrotropin. J Clin Endocrinol Metab 57:500
33. Toyoda N, Nishikawa M, Horimoto M, Yoshikawa N, Mori Y, Yoshimura M, Masaki H, Tanaka K, Inada M 1990 Synergistic effect of thyroid hormone and thyrotropin on iodothyronine 5’-deiodinase in FRTL-5 rat thyroid cells. Endocrinology 127:1199
34. Toyoda N, Nishikawa M, Horimoto M, Yoshikawa N, Mori Y, Yoshimura M, Masaki H, Tanaka K, Inada M 1990 Graves’ immunoglobulin G stimulates iodotyronine 5’-deiodinating activity in FRTL-5 rat thyroid cells. J Clin Endocrinol Metab 70:1506
35. Borges M, Ingbar SH, Silva JE 1990 Iodothyronine deiodinase activities in FRTL-5 cells: predominance of type I 5’-deiodinase. Endocrinology 126:3059
36. Pazo-Moura CC, Moura EG, Dorris ML, Rehnmark S, Melendez L, Silva JE, Taurog A 1991 Effect of iodine deficiency and cold exposure on thyroxine 5’-deiodinase activity in various rat tissues. Am J Physiol 260:E175
37. Abuid J, Larsen PR 1974 Triiodothyronine and thyroxine hyperthyroidism. J Clin Invest 54:201
38. Silva JE, Larsen PR 1986 Hormonal regulation of iodothyronine 5’-deiodinase in rat brown adipose tissue. Am J Physiol 251:E639
39. Bianco AC, Silva JE 1987 Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest 79:296
40. Bianco AC, Silva JE 1987 Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. Am J Physiol 253:E255
41. Silva JE, Larsen PR 1985 Potential of brown adipose tissue type II thyroxine 5’-deiodinase as a local and systemic source of triiodothyronine in rats. J Clin Invest 76:2296
42. Farwell AP, Leonard JL 1989 Identification of a 27-kDa protein with the properties of type II iodothyronine 5’-deiodinase in dibutyryl cyclic AMP-stimulated glial cells. J Biol Chem 264:20561
43. Farwell AP, Lynch RM, Okulicz WC, Comi AM, Leonard JL 1990 The actin cytoskeleton mediates the hormonally regulated translocation of type II iodothyronine 5’-deiodinase in astrocytes. J Biol Chem 265:18546
44. Silva JE, Matthews PS 1984 Production rates and turnover of triiodothyronine in rat developing cerebral cortex and cerebellum: responses to hypothyroidism. J Clin Invest 74:1035
45. Mol JA, van den Berg TP, Visser TJ 1988 Partial purification of the microsomal rat liver iodothyronine deiodinase I. Solubilization and ion-exchange chromatography. Mol Cell Endocrinol 55:149
46. Mol JA, van den Berg TP, Visser TJ 1988 Partial purification of the microsomal rat liver iodothyronine deiodinase II. Affinity chromatography. Mol Cell Endocrinol 55:159
47. Safran M, Kohrle J, Braverman LE, Leonard JL 1990 Effect of biological alterations of type I 5’-deiodinase activity on affinity-labeled membrane proteins in rat liver and kidney. Endocrinology 126:826
48. Kohrle J, Rasmussen UB, Rokos H, Leonard JL, Hesch RD 1990 Selective affinity labelling of a 27-kDa integral membrane protein in rat liver and kidney with iV-bromoacetyl derivatives of L-thyroxine and 3,5,3’-triiodo-L-thyronine. J Biol Chem 265:6146
49. Kohrle J, Rasmussen UB, Ekenbarger DM, Alex S, Rokos H, Hesch RD, Leonard JL 1990 Affinity labelling of rat liver and kidney type I 5’-deiodinase. J Biol Chem 265:6155
50. Safran M, Leonard JL 1991 Comparison of the physicochemical properties of type I and type II iodothyronine 5’-deiodinase. J Biol Chem 266:3233
51. Boado RJ, Campbell DA, Chopra IJ 1988 Nucleotide sequence of rat liver iodothyronine 5’-monodeiodinase (5’MD): its identity with the protein disulfide isomerase. Biochem Biophys Res Commun 155:1297
52. Schoenmakers CHH, Pigmans IGAJ, Hawkins HC, Freedman RB, Visser TJ 1989 Rat liver type I iodothyronine deiodinase is not identical to protein disulfide isomerase. Biochem Biophys Res Commun 162:857
53. Berry MJ, Kates AL, Larsen PR 1990 Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. Mol Endocrinol 4:743
54. St. Germain DL, Morganelli CM 1989 Expression of type I iodothyronine 5’-deiodinase in Xenopus laeuis oocytes. J Biol Chem 264:3054
55. St.Germain DL, Dittrich W, Morganelli CM, Cryns V 1990 Molecular cloning by hybrid arrest of translation in Xenopus laeuis oocytes. J Biol Chem 265:20087
56. Berry MJ, Banu L, Larsen PR 1991 Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature 349:438
57. Chambers I, Frampton J, Goldfarb P, Affara N, McBain W, Harrison PR 1986 The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the “termination” codon, TGA. EMBO J 5:1221
58. Zinoni F, Birkmann A, Stadtman T, Bock A 1986 Nucleotide sequence and expression of the selenocysteine-containing polypeptide of formate dehydrogenase (formate-hydrogenase-lyase-linked) from Escherichia coli. Proc Natl Acad Sci USA 83:4650
59. Garcia GE, Stadtman TC 1991 Selenoprotein A component of the glycine reductase complex from Clostridium purinolyticum: nucleotide sequence of the gene shows that selenocysteine is encoded by UGA. J Bacteriol 173:2093
60. Beckett GJ, Beddows SE, Morrice PC, Nicol F, Arthur JR 1987 Inhibition of hepatic deiodination of thyroxine is caused by selenium deficiency in rats Biochem J 248:443
61. Arthur JR, Nicol F, Hutchinson AR, Beckett GJ 1990 The effects of selenium depletion and repletion on the metabolism of thyroid hormones in the rat. J Inorg Biochem 39:101
62. Beckett GJ, MacDougall DA, Nicol F, Arthur JR, 1989 Inhibition of type I and type II iodothyronine deiodinase activity in rat liver, kidney and brain produced by selenium deficiency. Biochem J 259:887
63. Beckett GJ, Nicol F, Proudfoot D, Dyson K, Loucaides G, Arthur JR 1990 The changes in hepatic enzyme expression caused by selenium deficiency and hypothyroidism in rats are produced by independent mechanisms. Biochem J 266:743
64. Arthur JR, Nicol F, Rae PWH, Beckett GJ 1990 Effects of selenium deficiency on the thyroid gland and on plasma and pituitary thyrotrophin and growth hormone concentrations in the rat. Clin Chem Enzymol Commun 3:209
65. Behne D, Hilmert H, Scheid S, Gessner H, Eiger W 1988 Evidence for specific selenium target tissues and new biologically important selenoproteins. Biochem Biophys Acta 966:1251
66. Safran M, Farwell AP, Leonard JL 1991 Evidence that type II 5’-deiodinase is not a selenoprotein. J Biol Chem 266:13477
67. Berry MJ, Kieffer JD, Larsen PR 1991 Evidence that cysteine, not selenocysteine, is in the catalytic site of type II iodothyronine deiodinase. Endocrinology 129:550
68. Behne D, Scheid S, Kyriakopoulos A, Hilmert H 1990 Subcellular distribution of selenoproteins in the liver of the rat. Biochem Biophys Acta 1033:219
69. Behne D, Kyriakopoulos A, Meinhold H, Kohrle J 1990 Identification of Type I iodothyronine 5’-deiodinase as a selenoenzyme. Biochem Biophys Res Commun 173:1143
70. Arthur JR, Nicol F, Beckett GJ 1990 Hepatic iodothyronine 5’-deiodinase: the role of selenium. Biochem J 272:537
71. Berry MJ, Kieffer JD, Harney JW, Larsen PR 1991 Selenocysteine confers the biochemical properties of the type I iodothyronine deiodinase. J Biol Chem 266:14155
72. Chaudiere J, Tappel AL 1984 Interaction of gold(I) with the active site of selenium glutathione peroxidase. J Inorg Biochem 20:313
73. Chanoine JP, Safran M, Farwell AP, Arthur JR, Beckett GJ, Leonard JL, Effects of selenium deficiency on brain type II iodothyronine 5’-deiodinase in rats. Program of the 65th Annual Meeting of the American Thyroid Association, Boston, 1991 (Abstract 45)
74. Mizutani T, Kurata H, Yamada K 1991 Study of mammalian selenocysteyl-tRNA synthesis with [78Se]HSe-. Fed Eur Biochem Soc 289:59
75. Bock A, Forchhammer K, Heider J, Leinfelder W, Sawers G, Veprek B, Zinoni F 1991 Selenocysteine: the 21st amino acid. Mol Microbiol 5:515
76. Stadtman TC 1990 Selenium Biochemistry. Annu Rev Biochem 59:111
77. Axley MJ, Bock A, Stadtman TC 1991 Catalytic properties of an Escherichia coli formate dehydrogenase mutant in which sulfur replaces selenium. Proc Natl Acad Sci USA 88:8450
78. Oikawa T, Nobuyoshi E, Tanaka H, Soda K 1991 Metalloselenonein, the selenium analogue of metallothionein: synthesis and characterization of its complex with copper ions. Proc Natl Acad Sci USA 88:3057
79. Wu ZP, Hilvert D 1989 Conversion of a protease into an acyl transferase: selenosubtilisin. J Am Chem Soc 111:4513
80. Wu ZP, Hilvert D 1990 Selenosubtilisin as a glutathione peroxidase mimic. J Am Chem Soc 112:5647
81. Lee BJ, Worland PJ, Davis JN, Stadtman TC, Hatfield DL 1989 Identification of a selenocysteyl-tRNASer in mammalian cells that recognizes the nonsense codon, UGA. J Biol Chem 264:9724
82. Forchhammer K, Leinfelder W, Bock A 1989 Identification of a novel translation factor necessary for the incorporation of selenocysteine into protein. Nature 342:453
83. Zinoni F, Heider J, Bock A 1990 Features of the formate dehydrogenase mRNA necessary for decoding of the UGA codon as selenocysteine. Proc Natl Acad Sci USA 87:4660
84. Berry MJ, Banu L, Chen Y, Mandel SJ, Kieffer JD, Harney JW, Larsen PR 1991 Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3’ untranslated region. Nature 353:273
85. Saberi M, Sterling FH, Utiger RD 1975 Reduction in extrathyroidal triiodothyronine production by propylthiouracil in man. J Clin Invest 55:218
86. Geffner DL, Azukizawa M, Hershman JM 1975 Propylthiouracil blocks extrathyroidal conversion of thyroxine to triiodothyronine and augments thyrotropin secretion in man. J Clin Invest 55:224
87. LoPresti JS, Eigen A, Kaptein E, Anderson KP, Spencer CA, Nicoloff JT 1989 Alteration in 3,3’,5’-triiodothyronine metabolism in response to propylthiouracil, dexamethasone, and thyroxine administration in man. J Clin Invest 84:1650
88. Mandel SJ, Berry MJ, Kieffer JD, Harney JW, Warne RL, Larsen PR, Cloning and in vitro expression of human selenoprotein, Type I iodothyronine deiodinase. J Clin Endocrinol Metab, in press
89. Goyens P, Golstein J, Nsombola B, Vis H, Dumont JE 1987 Selenium deficiency as a possible factor in the pathogenesis of myxoedematous endemic cretinism. Acta Endocrinol (Copenh) 114:497
90. Vanderpas JB, Contempre B, Duale NL, Goossens W, Bebe N, Thorpe R, Ntambue K, Dumont J, Thilly CH, Diplock AT 1990 Iodine and selenium deficiency associated with cretinism in northern Zaire. Am J Clin Nutr 52:1087
91. Contempre B, Dumont JE, Bebe N, Thilly CH, Diplock AT, Vanderpas J 1991 Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. J Clin Endocrinol Metab 73:213
92. Kleinhaus N, Faber J, Kahana L, Schneer J, Scheinfeld M 1988 Euthyroid hyperthyroxinemia due to a generalized 5’-deiodinase defect. J Clin Endocrinol Metab 66:684
93. Maxon HR, Burman KD, Premachandra BN, Chen IW, Burger A, Levy P, Georges LP 1982 Familial elevations of total and free thyroxine in healthy, euthyroid subjects without detectable binding protein abnormalities. Acta Endocrinol (Copenh) 100:224