Hypoxia-Selective Antitumor Agents. 5. Synthesis of Water-Soluble Nitroaniline Mustards with Selective Cytotoxicity for Hypoxic Mammalian Cells

Journal of Medicinal Chemistry

Volumn 35, Issue 17, 1992, Pages 3214-3222

  Wilson, William R ^a   Cliffe, Stephen ^a   Palmer, Brian D ^b   Denny, William A ^b  

^a Department of Pathology ^*  (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROANILINE MUSTARD DERIVATIVE; 5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; 5 [BIS(2 CHLOROETHYL)AMINO] 2,4 DINITROBENZAMIDE; AMINE; ANTINEOPLASTIC AGENT; HYDROXYLAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SN 23862; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVATION; DRUG DESIGN; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYPOXIA; HYPOXIC CELL; NONHUMAN; PRIORITY JOURNAL; REDUCTION;

ANILINE COMPOUNDS; ANILINE MUSTARD; ANIMAL; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CHEMISTRY, PHYSICAL; CHO CELLS; COMPARATIVE STUDY; HAMSTERS; HUMAN; MOLECULAR STRUCTURE; MUSTARD COMPOUNDS; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATION-REDUCTION; OXYGEN; RATS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED; WATER;

EID: 0026665360     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00095a018     Document Type: Article

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