Kinetic analysis of recombinant antibody-antigen interactions: Relation between structural domains and antigen binding

Bio/Technology

Volumn 10, Issue 6, 1992, Pages 697-698

  Borrebaeck, Carl A K ^a   Malmborg, Ann Christin ^a   Furebring, Christina ^a   Michaelsson, Anne ^a   Ward, Sally ^b   Danielsson, Lena ^a   Ohlin, Mats ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANTIBODY STRUCTURE; ANTIGEN ANTIBODY REACTION; ARTICLE; CHEMICAL REACTION KINETICS; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; BINDING SITES, ANTIBODY; BIOSENSING TECHNIQUES; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOGLOBULINS, FAB; KINETICS; MURAMIDASE; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T;

EID: 0026664254     PISSN: 0733222X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt0692-697     Document Type: Article

References (10)

1. Foote, J. and Milstein, C. 1991. Kinetic maturation of an immune response. Nature 352: 530-532.
2. Winter, G. and Milstein, C. 1991. Man made antibodies. Nature 349: 293-299.
3. Ward, E. S., Güssow, D., Griffith, A. D., Jones, P. T. and Winter, G. 1989. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature 341: 544-546.
4. Malmborg, A-C., Michaelsson, A., Ohlin, M., Jansson, B. and Borre-baeck, C. A. K. 1992. Real time analysis of antibody-antigen reaction kinetics. Scand. J. Immunol. In press.
5. Karlsson, R., Michaelsson, A. and Mattsson, L. 1991. Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system. J. Immunol. Methods 145: 229-240.
6. Fischmann, T. O., Bentley, G. A., Bhat, T. N., Boulot, G., Mariuzza, R. A., Phillips, S. E. V., Tello, D. and Poljak, R. J. 1991. Crystallo-graphic refinement of the three-dimensional structure of the FabD1. 3-lysozyme complex at 2. 5-A resolution. J. Biol. Chem. 266: 1291512920.
7. Nygren, H., Czerkinsky, C. and Stenberg, M. 1985. Dissociation of antibodies to surface-immobilized antigen. J. Immunol. Methods 85: 87-95.
8. Nygren, H., Werthen, M. and Stenberg, M. 1987. Kinetics of antibody binding to solid-phase immobilized antigen. Effect of diffusion rate limitation and steric interaction, j. Immunol. Methods 101: 63-71.
9. Mariuzza, R. A., Jankovic, D. L. J., Boulot, G., Amit, A. G., Saludjian, P., Le Guern, A., Mazie, J. C. and Poljak, R. J. 1983. Preliminary crystallographic study of the complex between the Fab fragment of a monoclonal and-lysozyme antibody and its antigen. J. Mol. Biol. 170: 1055-1058.
10. Ward, E. S. 1991. Expression and purification of antibody fragments using Escherichia coli as a host, p. 121-137. In: Antibody Engineering. A Practical Guide. Borrebaeck, C. A. K. (Ed.). W. H. Freeman and Company, New York.