Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication

Antiviral Research

Volumn 19, Issue 1, 1992, Pages 55-70

  Korba, Brent E ^a   Gerin, John L ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Antiviral agent; Cell culture; Hepatitis B virus; Nucleoside analog; Standardized assay

Indexed keywords

2',3' DIDEOXYGUANOSINE; 2',3' DIDEOXYNUCLEOSIDE; 2',3' DIDEOXYTHYMIDINE; 2',3' DIDEOXYURIDINE; ANTIVIRUS AGENT; FURANOSIDE; NUCLEOSIDE ANALOG; UNCLASSIFIED DRUG; VIDARABINE; ZALCITABINE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; CELLS, CULTURED; DNA REPLICATION; DNA, VIRAL; HEPATITIS B VIRUS; NUCLEIC ACID HYBRIDIZATION; NUCLEOSIDES; SUPPORT, U.S. GOV'T, P.H.S.; VIRUS REPLICATION;

ANIMALIA; HEPADNAVIRIDAE; HEPATITIS B VIRUS;

EID: 0026663576     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-3542(92)90056-B     Document Type: Article

References (26)

1. Epidemiology of hepatocellular carcinoma
2. Antiviral strategies in chronic hepatitis B virus infection: I. Inhibition of duck hepatitis B virus in vitro using conventional antiviral agents and supercoiled-DNA active compounds
3. Synthesis and biological effects of 2′-fluoro-5-ethyl-1-B-D-arabinofuranouracil
4. Dye uptake methods for assessing viral cytopathogenicity and their application to interferon assays
5. Inhibitory effects of 2′-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks
6. Hepadnavirus-induced liver cancer in woodchucks
7. Current status and future directions in the treatment of chronic viral hepatitis
8. In vitro and in vivo comparison of the abilities of purine and pyrimidine 2′,3′-dideoxynucleosides to inhibit duck hepadnavirus
9. Woodchuck hepatitis virus infection as a model for the development of antiviral therapies against HBV
10. A cell culture assay for compounds which inhibit hepatitis B virus replication
11. Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections
12. Hepadnavirus infection of peripheral blood lymphocytes in vivo: Woodchuck and chimpanzee models of viral hepatitis
13. Development and application of an in vitro model for screening anti-hepatitis B virus therapeutics
14. Potent inhibition of hepatitis B virus production in vitro by modified pyrimidine nucleosides
15. Relation of the hepatitis B virus carrier state to hepatocellular carcinoma
16. Inhibition of the replication of hepatitis B virus by the carbocyclic analogue of 2′-deoxyguanosine
17. Treatment of hepatitis B viral infection
18. The Hepatitis B virus
19. Structure-activity relationships in adenosine deaminase inhibitors
20. Biochemical and genetic evidence for the hepatitis B virus replication strategy
21. Replication intermediates of hepatitis B virus in HepG2 cells that produce infectious virions
22. Replication of the genome of a hepatitis-B-like virus by reverse transcription of an RNA intermediate
23. Inhibition of duck hepatitis B virus replication by purine 2′,3′-dideoxynucleosides
24. An in vitro system for screening antihepatitis B virus drugs
25. Synthesis and anti-HIV evaluation of 2′,3′-dieoxyribochloropyrimidine analogues: Reduced toxicity of 5-chlorinated 2′,3′-dideoxynucleosides
26. Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis