Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF

Experimental Neurology

Volumn 117, Issue 2, 1992, Pages 114-123

  Cheng, Bin ^a,b   Mattson, Mark P ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CALCIUM ION; EPIDERMAL GROWTH FACTOR; GLUCOSE; NERVE GROWTH FACTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ANTIGENICITY; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL PROTECTION; FETUS; GLUCOSE BRAIN LEVEL; GLUCOSE UTILIZATION; HIPPOCAMPUS; HYPOGLYCEMIA; IMMUNOREACTIVITY; NERVE CELL DEGENERATION; NERVE CELL LESION; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; FETUS; FIBROBLAST GROWTH FACTOR 2; FURA-2; GLUCOSE; HIPPOCAMPUS; HYPOGLYCEMIA; NERVE GROWTH FACTORS; NEUROFIBRILLARY TANGLES; NEURONS; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TAU PROTEINS; UBIQUITINS;

EID: 0026659777     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/0014-4886(92)90120-F     Document Type: Article

References (66)

1. Basic fibroblast factor prevents death of lesioned cholinergic neurons in vivo
2. Hypoglycemic brain injury in the rat. Correlation of density of brain damage with the EEG isoelectric time: A quantitative study
3. Progress review: Hypoglycemic damage
4. Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease
5. Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids
6. How to Use Ridit Analysis
7. NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis
8. Glutamate neurotoxicity and diseases of the nervous system
9. Sustained increase in intracellular calcium promotes neuronal survival
10. Ridit analysis in dental clinical studies
11. The effects of fluctuation of blood glucose levels on the psychological performance of juvenile diabetics
12. Amelioration of cholinergic neurons atrophy and spatial memory impairment in aged rats by nerve growth factor
13. NGF receptor re-expression and NGF mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum
14. Regional changes in brain glucose metabolism reflect cognitive impairment in aged rats
15. The nerve growth factor: biochemistry, synthesis, and mechanism of action
16. Glucose effects on memory: behavioral and pharmacological characteristics
17. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.
18. A new generation of calcium indicators with greatly improved fluorescence properties
19. Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbrial transections
20. Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases
21. Ischemia and the aging brain: studies on glucose and energy metabolism in rat cerebral cortex
22. Glucose and related brain metabolism in dementia of Alzheimer type and its morphological significance
23. Glucose metabolism as the site of the primary abnormality in early-onset dementia of Alzheimer type
24. Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type
25. Diminished glucose transport in Alzheimer's disease: Dynamic PET studies
26. Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer's disease
27. Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II
28. 2+
29. Epitopes that span the tau molecule are shared with paired helical filaments
30. Nerve growth factor treatment after brain injury prevents neuronal death
31. Memory enhancement with posttraining intraventricular glucose injections in rats
32. Nerve growth factor as a paradigm for other polypeptide growth factors
33. Cerebral energy state in insulin-induced hypoglycemia, related to blood glucose and to EEG
34. Phosphorylation affects the ability of tau protein to promote microtubule assemly
35. Alz-50, ubiquitin and tau immunoreactivity of neurofibrillary tangles
36. Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases
37. Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons
38. Isolated hippocampal neurons in cryopreserved long-term cultures: development of neuroarchitecture and sensitivity to NMDA
39. Fibroblast growth factor and glutamate: Opposing roles in the generation and degeneration of hippocampal neuroarchitecture
40. Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons
41. Second messengers in neuronal growth and degeneration
42. Glia protect hippocampal neurons against excitatory amino acid-induced degeneration: involvement of fibroblast growth factor
43. Cell culture of cryopreserved human fetal cerebral cortical and hippocampal neurons: Neuronal development and responses to trophic factors
44. Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons
45. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
46. Effects of changes in peripheral and cerebral glucose metabolism on locomotor activity, learning and memory in adult male rats
47. Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase
48. Memory improvement by glucose, fructose, and two glucose analogs: A possible effect on peripheral glucose transport
49. Glucose deprivation neuronal injury in cortical culture
50. Ubiquitin is a component of paired helical filaments in Alzheimer's disease
51. Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture
52. The intracerebroventricular streptozotocin-treated rat: impairment of cerebral glucose metabolism resembles the alterations of carbohydrate metabolism of the brain in Alzheimer's disease
53. Cortical glucose metabolism in Parkinson's and Alzheimer's diseases
54. Ubiquitin is detected in neurofibrillary tangles and senile plague neurites of Alzheimer's disease
55. Glucocorticoids and hippocampal damage
56. The molecular pathology of Alzheimer's disease
57. Amelioration of delayed neuronal death in hippocampus by nerve growth factor
58. Calcium, excitotoxins, and neuronal death in the brain
59. Neurotrophic molecules
60. Retrograde changes in cholinergic neurons in the basal forebrain of the rat following cortical damage
61. 2+-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles
62. The physiological function of nerve growth factor in the central nervous system: comparison with the periphery
63. Alz-50 recognizes a phosphorylated epitope in tau
64. Fibroblast growth factor promotes survival of dissociated hippocampal neurons and promotes neurite extension
65. Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist
66. A neuronal antigen in the brains of Alzheimer's patients