Higher levels of control: Modulation of steroid hormone-regulated gene transcription

Molecular Endocrinology

Volumn 6, Issue 7, 1992, Pages 995-1002

  Simons, S Stoney ^a   Oshima, Hisaji ^a   Szapary, Daniele ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; MESSENGER RNA; MIFEPRISTONE; STEROID HORMONE; STEROID HORMONE ANTAGONIST;

CELL DENSITY; ENZYME INDUCTION; GENE INDUCTION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HORMONE ACTION; HORMONE RESPONSIVE ELEMENT; MODULATION; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY; SHORT SURVEY;

ANIMAL; DEXAMETHASONE; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HORMONES; HUMAN; MODELS, BIOLOGICAL; RECEPTORS, CELL SURFACE; RECEPTORS, GLUCOCORTICOID; RECEPTORS, STEROID; SIGNAL TRANSDUCTION; STEROIDS; TRANSCRIPTION, GENETIC;

EID: 0026658867     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/mend.6.7.1324423     Document Type: Article

References (101)

1. Munck A, Foley R 1979 Activation of steroid hormone-receptor complexes in intact target cells in physiological conditions. Nature 278:752-754
2. Markovic RD, Litwack G 1980 Activation of liver and kidney glucocorticoid-receptor complexes occurs in vivo. Arch Biochem Biophys 202:374-379
3. Munck A, Holbrook NJ 1984 Glucocorticoid-receptor complexes in rat thymus cells. Rapid kinetic behavior and a cyclic model. J Biol Chem 259:820-831
4. Munck A, Foley R 1980 Activated and non-activated glucocorticoid-receptor complexes in rat thymus cells: kinetics of formation, relation to steroid structure. J Steroid Biochem 12:225-230
5. Ojasoo T, Dore J-C, Gilbert J, Raynaud J-P 1988 Binding of steroid to the progestin and glucocorticoid receptors analyzed by correspondence analysis. J Med Chem 31:1160-1169
6. Lefebvre P, Formstecher P, Rousseau GG, Lustenberger P, Dautrevaux M 1989 Improvement in glucocorticoid receptor binding affinity concomitant to.shift from antagonist to agonist activity in a series of 17β-carboxamide derivatives of dexamethasone. J Steroid Biochem 33:557-563
7. Vanderbilt JN, Miesfeld R, Maler BA, Yamamoto KR 1987 Intracellular receptor concentration limits glucocorticoid-dependent enhancer activity. Mol Endocrinol 1:68-74
8. Webb P, Lopez GN, Greene GL, Baxter JD, Kushner PJ 1992 The limits of the cellular capacity to mediate an estrogen response. Mol Endocrinol 6:157-167
9. Rousseau GG, Baxter JD 1979 Glucocorticoid receptors. In: Baxter JD, Rousseau GG (eds) Glucocorticoid Hormone Action. Springer-Verlag, New York, pp 49-77
10. Bloom E, Matulich DT, Lan NC, Higgins SJ, Simons SS, Baxter JD 1980 Nuclear binding of glucocorticoid receptors: relations between cytosol binding, activation, and the biological response-induced effects. J Steroid Biochem 12:175-184
11. Steinberg RA, Levinson BB, Tomkins GM 1975 Kinetics of steroid induction and deinduction of tyrosine aminotransferase synthesis in cultured hepatoma cells. Proc Natl Acad Sci USA 72:2007-2011
12. Becker PB, Gloss B, Schmid W, Strahle U, Schütz G 1986 In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone. Nature 324:686-688
13. Rousseau GG, Schmit J-P 1977 Structure-activity relationships for glucocorticoids. Determination of receptor binding and biological activity. J Steroid Biochem 8:911-919
14. Simons SS, Yen PM 1987 Variations in agonist activity among antiglucocorticoid steroids and its relation to glucocorticoid regulated genes. In: Spelsberg TC, Kumar R (eds) Steroid and Sterol Hormone Action. M Nijhoff, Boston, pp 251-268
15. Mercier L, Thompson EB, Simons SS 1983 Dissociation of steroid binding to receptors and steroid induction of biological activity in a glucocorticoid responsive cell. Endocrinology 112:601-609
16. Mercier L, Miller PA, Simons SS 1986 Antiglucocorticoid steroids have increased agonist activity in those hepatoma cell lines that are more sensitive to glucocorticoids. J Steroid Biochem 25:11-20
17. Killary AM, Fournier REK 1984 A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell 38:523-534
18. Schmid W, Muller G, Schütz G, Gluecksohn-Waelsch S 1985 Deletions near the albino locus on chromosome 7 of the mouse affect the level of tyrosine aminotransferase mRNA. Proc Natl Acad Sci USA 82:2866-2869
19. Diamond MI, Miner JN, Yoshinaga SK, Yamamoto KR 1990 Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249:1266-1272
20. Privalsky ML, Sharif M, Yamamoto KR 1990 The viral erbA ocogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast. Cell 63:1277-1286
21. Tanaka H, Dong Y, Li Q, Okret S, Gustafsson J-A 1991 Identification and characterization of a cis-acting element that interferes with glucocorticoid-inducible activation of the mouse mammary tumor virus promoter. Proc Natl Acad Sci USA 88:5393-5397
22. Simons Jr SS, Mercier L, Miller NR, Miller PA, Oshima H, Sistare FD, Thompson EB, Wasner G, Yen PM 1989 Differential modulation of gene induction by glucocorticoids and antiglucocorticoids in rat hepatoma tissue culture cells. Cancer Res 49:2244s-2252s
23. Wasner G, Oshima H, Thompson EB, Simons SS 1988 Unlinked regulation of the sensitivity of primary glucocorticoid-inducible responses in mouse mammary tumor virus-infected Fu5-5 rat hepatoma cells. Mol Endocrinol 2:1009-1017
24. Simons Jr SS, Miller PA, Wasner G, Miller NR, Mercier L1988 Inverse correlation between dexamethasone 21-mesylate agonist activity and sensitivity to dexamethasone for induction of tyrosine aminotransferase in rat hepatoma cells. J Steroid Biochem 31:1-7
25. Thompson EB, Gadson P, Wasner G, Simons SS 1989 Differential regulation of tyrosine aminotransferase by glucocorticoids: transcriptional and post-transcrip-tional control. In: Roy AK, Clark JH (eds) Gene Regulation by Steroid Hormones IV. Springer-Varlag, New York, pp 63-76
26. Oshima H, Simons Jr SS 1992 Modulation of glucocorticoid induction of tyrosine aminotransferase gene expression by variations in cell density. Endocrinology 130:2106-2112
27. Szapary D, Oshima H, Simons Jr SS 1992 Modulation of glucocorticoid induction of stably transfected tyrosine aminotransferase gene constucts involves elements upstream of the glucocorticoid responsive element. Endocrinology 130:3492-3502
28. Quirk SJ, Funder JW 1988 Steroid receptors and the generation of closely coupled/biphasic dose-response curves. J Steroid Biochem 30:9-15
29. Gagne D, Labhilli M, Pons M 1988 Description and analysis of differential sensitivity to glucocorticoid in Fao cells. J Steroid Biochem 31:917-925
30. Liley HG, White RT, Benson BJ, Ballard PL 1988 Glucocorticoids both stimulate and inhibit production of pulmonary surfactant protein A in fetal human lung. Proc Natl Acad Sci 85:9096-9100
31. Nordeen SK, Kuhnel B, Lawler-Heavner J, Barber DA, Edwards DP 1989 A quantitative comparison of dual control of a hormone response element by progestins and glucocorticoids in the same cell line. Mol Endocrinol 3:1270-1278
32. Russo-Marie F, Paing M, Duval D 1979 Involvement of glucocorticoid receptors in steroid-induced inhibition of prostaglandin secretion. J Biol Chem 254:8498-8504
33. Rotsztejn WH, Dussaillant M, Nobou F, Rosselin G 1981 Rapid glucocorticoid inhibition of vasoactive intestinal peptide-induced cyclic AMP accumulation and prolactin release in rat pituitary cells in culture. Proc Natl Acad Sci USA 78:7584-7588
34. Cook PW, Swanson KT, Edwards CP, Firestone GL 1988 Glucocorticoid receptor-dependent inhibition of cellular proliferation in dexamethasone-resistant and hypersensitive rat hepatoma cell variants. Mol Cell Biol 8:1449-1459
35. Webster MK, Guthrie J, Firestone GL 1990 Suppression of rat mammary tumor cell growth in vitro by glucocorticoids requires serum proteins. J Biol Chem 265:4831-4838
36. Pollanen J 1989 Down-regulation of plasmin receptors on human sarcoma cells by glucocorticoids. J Biol Chem 264:5628-5632
37. Houart C, Szpirer J, Szpirer C 1990 The alpha-foetopro-tein proximal enhancer: localization, cell specificity, and modulation by dexamethasone. Nucleic Acids Res 18:6277-6282
38. Jonat C, Rahmsdorf HJ, Park K-K, Cato ACB, Gebel S, Ponta H, Herrlich P 1990 Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62:1189-1204
39. Ihara H, Nakanishi S 1990 Selective inhibition of expression of the substance P receptor mRNA in pancreatic acinar AR42 J cells by glucocorticoids. J Biol Chem 265:22441-22445
40. Rosewicz S, McDonald AR, Maddux BA, Goldfine ID, Miesfeld RL, Logsdon CD 1988 Mechanism of glucocorticoid receptor down-regulation by glucocorticoids. J Biol Chem 263:2581-2584
41. Burnstein KL, Jewell CM, Cidlowski JA 1990 Human glucocorticoid receptor cDNA contains sequences sufficient for receptor down-regulation. J Biol Chem 265:7284-7291
42. Catterall JF, Watson CS, Kontula KK, Janne OA, Bardin CW 1986 Differential regulation of specific gene expression in mouse kidney by androgens and antiandrogens. In: Chrousos GP, Loriaux DL, Lipsett MB (eds) Steroid Hormone Resistance. Mechanisms and Clinical Aspects. Plenum Press, New York, pp 213-226
43. Lu J, Matsumoto K, Nishizawa Y, Tanaka A, Hirose T, Sato B 1991 Non-classical androgenic actions of RU38486 in androgen-responsive Shionogi carcinoma 115 cells in serum-free culture. J Steroid Biochem Mol Biol 39:329-335
44. Slater EP, Redeuihl G, Theis K, Suske G, Beato M 1990 The uteroglobin promoter contains a noncanonical estrogen responsive element. Mol Endocrinol 4:604-610
45. Amara JF, Itallie CV, Dannies PS 1987 Regulation of prolactin production and cell growth by estradiol: difference in sensitivity to estradiol occurs at level of messenger ribonucleic acid accumulation. Endocrinology 120:264-271
46. May FEB, Westley BR 1988 Identification and characterization of estrogen-regulated RNAs in human breast cancer cells. J Biol Chem 263:12901-12908
47. Westley BR, Holzel F, May FEB 1989 Effects of oestrogen and the antioestrogens, tamoxifen and LY117018, on four oestrogen-regulated RNAs in the EFM-19 breast cancer cell line. J Steroid Biochem 32:365-372
48. Evans MI, O’Malley PJ, Krust A, Burch JBE 1987 Developmental regulation of the estrogen receptor and the estrogen responsiveness of five yolk protein genes in the avian liver. Proc Natl Acad Sci USA 84:8493-8497
49. Barton MC, Shapiro DJ 1988 Transient administration of estradiol-17β establishes an autoregulatory loop permanently inducing estrogen receptor mRNA. Proc Natl Acad Sci USA 85:7119-7123
50. Cato ACB, Heitlinger E, Ponta H, Klein-Hitpass L, Ryffei GU, Bailly A, Rauch C, Milgrom E 1988 Estrogen and progesterone receptor-binding sites on the chicken vitellogenin II gene: synergism of steroid hormone action. Mol Cell Biol 8:5323-5330
51. Cato ACB, Miksicek R, Schütz G, Arnemann J, Beato M 1986 The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction. EMBO J 5:2237-2240
52. Quirk SJ, Gannell JE, Fullerton MJ, Funder JW 1985 Progestins specifically suppress a-lactalbumin synthesis and secretion. J Steroid Biochem 23:901-905
53. Alexander IE, Clarke CL, Shine J, Sutherland RL 1989 Progestin inhibition of progesterone receptor gene expression in human breast cancer cells. Mol Endocrinol 3:1377-1386
54. 3 receptor levels and augments bioresponses in rat osteoblast-like cells. Endocrinology 118:1119-1126
55. Simons SS, Structure-activity relationships of glucocorticoids: importance of the regulated gene and transacting factors in determining glucocorticoid and antiglucocorticoid activity. In: Bohl M, Duax WL (eds) Molecular Structure and Biological Activity of Steroids. CRC Press, Boca Raton, in press
56. Hackney JF, Holbrook NJ, Grasso RJ 1981 Progesterone as a partial glucocorticoid agonist in L929 mouse fibroblasts: effects on cell growth, glutamine synthetase induction and glucocorticoid receptors. J Steroid Biochem 14:971-977
57. Winguth SD, Firestone GL 1987 Dual regulation of protein maturation in viral-infected rat HTC hepatoma cells by glucocorticoids and progesterone. Mol Endocrinol 1:823-833
58. Webster NJG, Green S, Jin JR, Chambon P 1988 The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell 54:199-207
59. Schweizer-Groyer G, Cadepond F, Groyer A, Idziorek T, Manlier M, Baulieu EE 1988 Stimulation of specific transcription and DNA binding studies suggest that in vitro transformed RU486-glucocorticosteroid receptor complexes display agonist activity. J Steroid Biochem 30:291-294
60. Dong J-M, Nordloh PW, Chiu J-F 1989 The mechanism of the bidirectional regulation of the rat a-fetoprotein gene by glucocorticoid hormone. Mol Cell Endocrinol 66:109-114
61. Harbour DV, Chambon P, Thompson EB 1990 Steroid-mediated lysis of lymphoblasts requires the DNA binding region of the steroid hormone receptor. J Steroid Biochem 35:1-9
62. Tasset D, Tora L, Fromental C, Scheer E, Chambon P 1990 Distinct classes of transcriptional activating domains function by different mechanisms. Cell 62:1177-1187
63. Oshima H, Simons Jr SS 1992 Modulation of transcription factor activity by a distant steroid modulatory element. Mol Endocrinol 6:416-428
64. Horwitz KB 1985 The antiprogestin in RU38.486: recep-tor-mediated progestin versus antiprogestin actions screened in estrogen-insensitive T47Dco human breast cancer cells. Endocrinology 116:2236-2245
65. Marver D 1985 The mineralocorticoid receptor. Biochem Actions Horm 12:385-431
66. Rauch M, Loosfelt H, Philibert D, Milgrom E 1985 Mechanism of action of an antiprogesterone, RU486, in the rabbit endometrium. Effects of RU486 on the progesterone receptor and on the expression of the uteroglobin gene. Eur J Biochem 148:213-218
67. Berry M, Metzger D, Chambon P 1990 Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J 9:2811-2818
68. Sundstrom SA, Komm BS, Xu Q, Boundy V, Lyttle CR 1990 The stimulation of uterine complement component C3 gene expression by antiestrogens. Endocrinology 126:1449-1456
69. Turcotte B, Meyer M-E, Bocquel M-T, Belanger L, Chambon P 1990 Repression of the a-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormones. Mol Cell Biol 10:5002-5006
70. Meyer M-E, Pornon A, Ji J, Bocquel M-T, Chambon P, Gronemeyer H 1990 Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor. EMBO J 9:3923-3932
71. Cavanaugh AH, Simons Jr SS 1990 Glucocorticoid receptor binding to calf thymus DNA. 1. Identification and characterization of a macromolecular factor involved in receptor-steroid complex binding to DNA. Biochemistry 29:989-996
72. Cavanaugh AH, Simons Jr SS 1990 Glucocorticoid receptor binding to calf thymus DNA. 2. Role of a DNA-binding activity factor in receptor heterogeneity and a multistep mechanism of receptor activation. Biochemistry 29:996-1002
73. 3. Proc Natl Acad Sci USA 87:9751-9755
74. Mukherjee R, Chambon P 1990 A single-stranded DNA-binding protein promotes the binding of the purified oestrogen receptor to its responsive element. Nucleic Acids Res 18:5713-5716
75. Murray MB, Towle HC 1989 Identification of nuclear factors that enhance binding of the thyroid hormone receptor to a thyroid hormone response element. Mol Endocrinol 3:1434-1442
76. Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Naar AM, Kim SY, Boutin J-M, Glass CK, Rosenfeld MG 1992 RXRβ: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251-1266
77. Boshart M, Weih F, Schimdt A, Fournier REK, Schutz G 1990 A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1. Cell 61:905-916
78. Weih F, Stewart AF, Boshart M, Nitsch D, Schutz G 1990 In vivo monitoring of a cAMP-stimulated DNA-binding activity. Genes Dev 4:1437-1449
79. Ankenbauer W, Strahle U, Schutz G 1988 Synergistic action of glucocorticoid and estradiol responsive elements. Proc Natl Acad Sci USA 85:7526-7530
80. Schmid W, Strahle U, Schutz G, Schmitt J, Stunnenberg H 1989 Glucocorticoid receptor binds cooperatively to adjacent recognition sites. EMBO J 8:2257-2263
81. Ptashne M 1988 How eukaryotic transcriptional activators work. Nature 335:683-689
82. Lin Y-S, Carey M, Ptashne M, Green MR 1990 How different eukaryotic transcriptional activators can cooperate promiscuously. Nature 345:359-361
83. Pugh BF, Tjian R 1990 Mechanism of trancriptional activation by Sp1: evidence for coactivators. Cell 61:1187-1197
84. Schule R, Muller M, Kaltschmidt C, Renkawitz R 1988 Many transcription factors interact synergistically with steroid receptors. Science 242:1418-1420
85. Schule R, Muller M, Otsuka-Murakami H, Renkawitz R 1988 Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature 332:87-90
86. Strahle U, Schmid W, Schutz G 1988 Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J 7:3389-3395
87. Schatt MD, Rusconi S, Schaffner W 1990 A single DNA-binding transcription factor is sufficient for activation from a distant enhancer and/or from a promoter position. EMBO J 9:481-487
88. Imai E, Stronstedt P-E, Quinn PG, Carlstedt-Duke J, Gustafsson J-A, Granner DK 1990 Characterization of a compex glucocorticoid response unit in the phosphoen-olpyruvate carboxykinase gene. Mol Cell Biol 10:4712-4719
89. Yang-Yen H-F, Chambard J-C, Sun Y-L, Smeal T, Schmidt TJ, Drouin J, Karin M 1990 Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205-1215
90. Picard D, Salser SJ, Yamamoto KR 1988 A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor. Cell 54:1073-1080
91. Hollenberg SM, Evans RM 1988 Multiple and cooperative frans-activation domains of the human glucocorticoid receptor. Cell 55:899-906
92. Lees JA, Fawell SE, Parker MG 1989 Identification of two transactivation domains in the mouse oestrogen receptor. Nucleic Acids Res 17:5477-5488
93. Webster NJG, Green S, Tasset D, Ponglikitmongkol M, Chambon P 1989 The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon. EMBO J 8:1441-1446
94. Sabbah M, Gouilleux F, Sola B, Redeuilh G, Baulieu E-E 1991 Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response element. Proc Natl Acad Sci USA 88:390-394
95. Loeb JN, Strickland S 1987 Hormone binding and coupled response relationships in systems dependent on the generation of secondary mediators. Mol Endocrinol 1:75-82
96. Zaret KS, Yamamoto KR 1984 Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element. Cell 38:29-38
97. Buratowski S, Hahn S, Guarente L, Sharp PA 1989 Five intermediate complexes in transcription initiation by RNA polymerase II. Cell 56:549-561
98. Miller PA, Ostrowski MC, Hager GL, Simons Jr SS 1984 Covalent and noncovalent receptor-giucocorticoid complexes preferentially bind to the same regions of the long terminal repeat of murine mammary tumor virus proviral DNA. Biochemistry 23:6883-6889
99. Guiochon-Mantel A, Loosfelt H, Ragot T, Bailly A, Atger M, Misrahi M, Perricaudet M, Milgrom E 1988 Receptors bound to antiprogestin form abortive complexes with hormone responsive elements. Nature 336:695-698
100. Pham TA, Elliston JF, Nawaz Z, McDonnell DP, Tsai M-J, O’Malley BW 1991 Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers. Proc Natl Acad Sci USA 88:3125-3129
101. Landschulz WH, Johnson PF, McKnight SL 1988 The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240:1759-1764