Supraspinal μ2-opioid receptors mediate spinal/supraspinal morphine synergy

European Journal of Pharmacology

Volumn 220, Issue 2-3, 1992, Pages 275-277

  Pick, Chaim G ^a   Roques, Bernard ^b   Gacel, Gilles ^b   Pasternak, Gavril W ^a,c  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b CNRS   (France)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Analgesia; Morphine; Opioid receptors

Indexed keywords

MORPHINE; MU OPIATE RECEPTOR; OPIATE AGONIST; OPIATE ANTAGONIST; RECEPTOR SUBTYPE; TRIMU 5; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENTIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD;

ANALGESIA; ANIMAL; BRAIN STEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SPINAL; MALE; MICE; MORPHINE; OLIGOPEPTIDES; RECEPTORS, OPIOID, MU; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026658495     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(92)90761-R     Document Type: Article

References (5)

1. Investigation of the structural parameters involved in the μ and δ opioid receptor discrimination of linear enkephalin-related peptides
2. Different mu receptor subtypes mediate spinal and supraspinal analgesia in mice
3. Multiplicative interaction between narcotic agonisms expressed at spinal and supraspinal sites of antinociceptive action as revealed by concurrent intrathecal and intracerebroventricular injections of morphine