Orally Active Aldose Reductase Inhibitors: Indazoleacetic, Oxopyridazineacetic, and Oxopyridopyridazineacetic Acid Derivatives

Journal of Medicinal Chemistry

Volumn 35, Issue 12, 1992, Pages 2155-2162

  Mylari, Banavara L ^a,b   Zembrowski, William J ^a,b   Beyer, Thomas A ^a,b   Aldinger, Charles E ^a,b   Siegel, Todd W ^a,b  

^a PFIZER INC   (United States)

^b Department of Medicinal Chemistry ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,6 DIHYDRO 6 OXO 4,5 DIMETHYL 1 [(5,7 DIFLUORO 2 BENZOTHIAZOLYL)METHYL] 3 PYRIDAZINEACETIC ACID; 3 INDAZOLEACETIC ACID DERIVATIVE; 3,4,5,6,7,8 HEXAHYDRO 4 OXO 3 [(5 TRIFLUOROMETHYL 2 BENZOTHIAZOLYL)METHYL] 1 PHTHALAZINEACETIC ACID; ACETIC ACID DERIVATIVE; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; PONALRESTAT; SORBITOL; UNCLASSIFIED DRUG; ZOPOLRESTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG TISSUE LEVEL; ENZYME INHIBITION; LENS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SCIATIC NERVE; STREPTOZOCIN DIABETES; X RAY CRYSTALLOGRAPHY;

ACETIC ACIDS; ALDEHYDE REDUCTASE; ANIMAL; BINDING SITES; DIABETES MELLITUS, EXPERIMENTAL; HUMAN; INDAZOLES; PYRIDAZINES; RATS; SCIATIC NERVE; SORBITOL; THIAZOLES;

EID: 0026654543     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00090a002     Document Type: Article

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