Mambin, a Potent Glycoprotein Ilb-IIIa Antagonist and Platelet Aggregation Inhibitor Structurally Related to the Short Neurotoxins

Biochemistry

Volumn 31, Issue 20, 1992, Pages 4766-4772

  McDowell, Robert S ^a   Dennis, Mark S ^a   Mulkerrin, Michael G ^a   Lazarus, Robert A ^a   Louie, Andrea ^a   Shuster, Michael ^b  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; ERABUTOXIN B; FIBRINOGEN; FIBRINOGEN RECEPTOR; GLYCOPROTEIN; NEUROTOXIN; NICOTINIC RECEPTOR; SNAKE VENOM;

AMINO ACID SEQUENCE; ARTICLE; CIRCULAR DICHROISM; DISULFIDE BOND; HYBRID GENE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; RECEPTOR BINDING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SNAKE; THROMBOCYTE AGGREGATION; TOXIN STRUCTURE;

AMINO ACID SEQUENCE; COMPARATIVE STUDY; HUMAN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUROTOXINS; NICOTINIC ANTAGONISTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN CONFORMATION; PROTEINS; SEQUENCE ALIGNMENT; SPECTRUM ANALYSIS, MASS;

CROCODYLUS NILOTICUS; DENDROASPIS JAMESONI; ELAPIDAE; SERPENTES; VIPERIDAE;

EID: 0026650803     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00135a004     Document Type: Article

References (52)

1. Adler, M., Lazarus, R.A., Dennis, M.S., & Wagner, G. (1991) Science 253, 445-448.
2. Albelda, S.M., & Buck, C.A. (1990) FASEB J. 4, 2868-2880.
3. Banks, B.E.C., Miledi, R., & Shipolini, R.A. (1974) Eur. J. Biochem. 45, 457-468.
4. Barany, G., & Merrifield, R.B. (1980) in The Peptides (Gross, E., & Meienhofer, J., Eds.) pp 1-284, Academic Press, New York.
5. Barker, P.L., Burnier, J.P., Gadek, T., & Thorsett, E.D. (1991) PCT Intl. Appl. WO 91 01331 (Feb 7, 1991).
6. Becker, R.C., & Gore, J.M. (1991) Circulation 83, 1038-1047.
7. Bernstein, F.C., Koetzle, T.F., Williams, G.J.B., Meyer, E.F., Brice, M.D., Rodgers, J.R., Kennard, O., Shima-nouchi, T., & Tasumi, M. (1977) J. Mol. Biol. 112, 535-542.
8. Changeux, J.P., Devilliers-Thiery, A., & ChemoulU, P. (1984) Science 225, 1335-1345.
9. Coller, B.S., Folts, J.D., Scudder, L.E., & Smith, S.R. (1986) Blood 68, 783-786.
10. Cooke, R.M., Carter, B.G., Martin, D.M.A., Murray-Rust, P., & Weir, M.P. (1991) Eur. J. Biochem. 202, 323-328.
11. Dalvit, C., Widmer, H., Bovermann, G., Breckenridge, R., & Metternich, R. (1991) Eur. J. Biochem. 202, 315-321.
12. Dennis, M.S., Henzel, W.J., Pitti, R.M., Lipari, M.T., Napier, M.A., Deisher, T.A., Bunting, S., & Lazarus, R.A. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 2471-2475.
13. Doolittle, R.F. (1989) Trends Biochem. Sci. 14, 244-245.
14. Dufton, M.J., & Hider, R.C. (1983) CRC Crit. Rev. Biochem. 14, 113-171.
15. Dufton, M.J., Bladon, P., & Harvey, A.L. (1989) J. Mol. Evol. 29, 355-366.
16. Endo, T., & Tamiya, N. (1987) Pharmacol. Ther. 34, 403-454.
17. Fong, T.M., & McNamee, M.G. (1986) Biochemistry 25, 830-840.
18. Gan, Z.-R., Gould, R.J., Jacobs, J.W., Friedman, P.A., & Polokoff, M.A. (1988) J. Biol. Chem. 263, 19827-19832.
19. Garsky, V.M., Lumma, P.K., Freidinger, R.M., Pitzen-berger, S.M., Randall, W.C., Veber, D.F., Gould, R.J., & Friedman, P.A. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 4022-4026.
20. George, D.G., Barker, W.C., & Hunt, L. (1986) Nucleic Acids Res. 14, 11-15.
21. Gilbert, W.A. (1985) Science 228, 823-824.
22. Gold, H.K., Coller, B.S., Yasuda, T., Saito, T., Fallon, J.T., Guerrero, J.L., Leinbach, R.C., Ziskind, A.A., & Collen, D. (1988) Circulation 77, 670-677.
23. Gould, R.J., Polokoff, M.A., Friedman, P.A., Huang, T.-F., Holt, J.C., Cook, J.J., & Niewiarowski, S. (1990) Proc. Soc. Exp. Biol. Med. 195, 168-171.
24. Hawiger, J. (1990) Atheroscler. Rev. 21, 165-186.
25. Holmes, M.A., & Matthews, B.W. (1982) J. Mol. Biol. 160, 623-639.
26. Huang, T.-F., Holt, J.C., Lukasiewicz, H., & Niewiarowski, S. (1987) J. Biol. Chem. 262, 16157-16163.
27. Huang, T.-F., Holt, J.C., Kirby, E.P., & Niewiarowski, S. (1989) Biochemistry 28, 661-666.
28. Ishikawa, Y., Menez, A., Hori, H., Yoshida, H., & Tamiya, N. (1977) Toxicon 15, 471-488.
29. Joubert, F.J., & Taljaard, N. (1979) Biochim. Biophys. Acta 579, 228-233.
30. Kieffer, N., & Phillips, D.R. (1990) Annu. Rev. Cell Biol. 6, 329-357.
31. Kratzin, H.D., Palm, W., Stangel, M., Schmidt, W.E., Friedrich, J., & Hilschmann, N. (1989) Biol. Chem. Hoppe-Seyler 370, 263-272.
32. Lee, C.Y. (1979) Snake Venoms. Handbook of Experimental Pharmacology, Springer-Verlag, Berlin.
33. Low, B.W., & Corfield, P.W.R. (1988) in Neurotoxins in Neurochemistry (Dolly, I., & Oliver, J., Eds.) pp 13-26, Ellis Horwood Limited, Chichester.
34. Marquardt, D.W. (1963) J. Soc. Ind. Appl. Math. 11, 431-441.
35. Mazur, P., Henzel, W.J., Seymour, J.L., & Lazarus, R.A. (1991) Eur. J. Biochem., 202, 1073-1082.
36. McCarthy, M.P., & Stroud, R.M. (1989) Biochemistry 28, 40-48.
37. Phillips, D.R., Charo, I.F., Parise, L.V., & Fitzgerald, L.A. (1988) Blood 71, 831-843.
38. Plow, E.F., & Ginsburg, M.H. (1989) Prog. Hemostasis Thromb. 9, 117-156.
39. Rucinski, B., Niewiarowski, S., Holt, J.C., Soszka, T., & Knudsen, K.A. (1990) Biochim. Biophys. Acta 1054, 257-262.
40. Ruoslahti, E., & Pierschbacher, M.D. (1987) Science 238, 491-497.
41. Saudek, V., Atkinson, R.A., & Pelton, J.T. (1991) Biochemistry 30, 7369-7372.
42. Seymour, J.L., Henzel, W.J., Nevins, B., Stults, J.T., & Lazarus, R.A. (1990) J. Biol. Chem. 265, 10143-10147.
43. Smith, J.L., Corfield, P.W.R., Hendrickson, W.A., & Low, B.W. (1988) Acta Crystallogr. A 44, 357-358.
44. Stocker, K.F. (1990) Medical Use of Snake Venom Proteins, CRC Press, Boca Raton, FL.
45. Strydom, D.J. (1972) J. Biol. Chem. 247, 4029-4042.
46. Strydom, D.J. (1979) in Snake Venoms. Handbook of Experimental Pharmacology (Lee, C.Y., Ed.) pp 258-275, Springer-Verlag, Berlin.
47. Strydom, D.J., & Botes, D.P. (1971) Biol. Chem. 247, 1341-1349.
48. Tamiya, N., & Arai, H. (1966) Biochem. J. 99, 624-630.
49. Thannhauser, T.W., Konishi, Y., & Scheraga, H.A. (1984) Anal. Biochem. 138, 181-188.
50. Weiner, S.J., Kollman, P.A., Case, D.A., Singh, U.C., Ghio, C., Alagona, G., Profeta, S., Jr., & Weiner, P. (1984) J. Am. Chem. Soc. 106, 765-784.
51. Weiner, S.J., Kollman, P.A., Nguyen, D.T., & Case, D.A. (1986) J. Comput. Chem. 7, 230-252.
52. Yasuda, T., Gold, H.K., Leinbach, R.C., Yaoita, H., Fallon, J.T., Guerrero, L., Napier, M.A., Bunting, S., & Collen, D. (1991) Circulation 83, 1038-1047.