Cyclization reactions of β,β-difluoroalkyl radicals (-CF2-C·) for synthesizing gem-difluorocyclic compounds

Tetrahedron

Volumn 48, Issue 41, 1992, Pages 8915-8926

  Morikawa, Tsutomu ^a   Kodama, Yoshitoshi ^a   Uchida, Jun ^a   Takano, Masami ^a   Washio, Yoshiaki ^a   Taguchi, Takeo ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

gem Difluorocyclohexane; gem Difluorocyclopentane; gem Difluorotetrahydropyran; Radical cyclization; , Difluoroalkyl radical

Indexed keywords

CYCLOALKANE DERIVATIVE; ORGANOFLUORINE DERIVATIVE; TETRAHYDROPYRAN DERIVATIVE;

ARTICLE; REACTION ANALYSIS; SYNTHESIS;

EID: 0026649490     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(01)81990-6     Document Type: Article

References (30)

1. The Design and Application of Free Radical Chain Reactions in Organic Synthesis. Part 1
2. The Design and Application of Free Radical Chain Reactions in Organic Synthesis. Part 2
3. Radical induced regio- and stereoselective ring-opening of gem-difluorocyclopropanes. Synthesis of the (E)-difluoroallylic system.
4. Free-radical approach to C-C bond formation on a trifluoromethyl-substituted carbon. Intramolecular cyclization.
5. Iodine atom-transfer ring-opening of 1,1-difluoro-2-(1-iodoalkyl)cyclopropanes by free-radical reaction.
6. Radical-induced ring opening of epoxides. A convenient alternative to the wharton rearrangement