Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice a new model of myasthenia gravis

Journal of Clinical Investigation

Volumn 90, Issue 1, 1992, Pages 245-250

  Schönbeck, Simone ^a,b   Padberg, Frank ^a   Hohlfeld, Reinhard ^a,b   Wekerle, Hartmut ^a  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Acetylcholine receptor; Auto sensitization; Autoimmunity; Thymus

Indexed keywords

ANTIBODY; CELL ADHESION MOLECULE; CHOLINERGIC RECEPTOR; CYTOKINE; IMMUNOGLOBULIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CELL SURVIVAL; CHIMERA; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; ETIOLOGY; GRAFT REJECTION; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENCE; IMMUNOCYTOCHEMISTRY; IMMUNOGLOBULIN DEPOSITION; LYMPHOCYTE; MOUSE; MYASTHENIA GRAVIS; NERVE ENDING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SKELETAL MUSCLE; THYMUS; TRANSPLANTATION;

ANIMAL; AUTOANTIBODIES; AUTOIMMUNITY; DISEASE MODELS, ANIMAL; HUMAN; IMMUNOGLOBULIN G; MICE; MICE, SCID; MYASTHENIA GRAVIS; RECEPTORS, CHOLINERGIC; SUPPORT, NON-U.S. GOV'T; THYMUS GLAND;

EID: 0026648331     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI115843     Document Type: Article

References (30)

1. Castleman, B. 1966. The pathology of the thymus in myasthenia gravis. Ann. N. Y. Acad. Sci. 135:496-503.
2. Engel, A. G. 1984. Myasthenia gravis and myasthenic syndromes. Ann. Neurol. 16:519-534.
3. Mulder, D. G., M. Graves, and C. Herrmann. 1989. Thymectomy for myasthenia gravis: recent observations and comparisons with past experience. Ann. Thorac. Surg. 48:551-555.
4. Wekerle, H., and U.-P. Ketelsen. 1977. Intrathymic pathogenesis and dual genetic control of myasthenia gravis. Lancet. 1:678-680.
5. Wekerle, H., B. Paterson, U.-P. Ketelsen, and M. Feldman. 1975. Striated muscles fibers differentiate in monolayer cultures of adult thymus reticulum. Nature (Lond.). 256:493-494.
6. Kao, I., and D. B. Drachman. 1977. Thymic muscle cells bear acetylcholine receptors: possible relation to myasthenia gravis. Science (Wash. DC). 195:74-75.
7. Wekerle, H., R. Hohlfeld, U.-P. Ketelsen, J. R. Kalden, and I. Kalies. 1981. Thymic myogenesis, T lymphocytes and the pathogenesis of myasthenia gravis. Ann. NY. Acad. Sci. 377:455-476.
8. Kirchner, T., S. Tzartos, F. Hoppe, B. C. G. Schalke, H. Wekerle, and H. K. Müller-Hermelink. 1988. Pathogenesis of myasthenia gravis. Acetylcholine receptor-related antigenic determinants in tumor-free thymuses and thymic epithelial tumors. Am. J. Pathol. 130:268-280.
9. Kirchner, T., F. Hoppe, B. Schalke, and H. K. Müller-Hermelink. 1988. Microenvironment of thymic myoid cells in myasthenia gravis. Virchows Arch. Pathol. Anal. Physiol. Klin. Med. 54:295-302.
10. Schluep, M., N. Willcox, A. Vincent, G. K. Dhoot, and J. Newsom-Davis. 1987. Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study. Ann. Neurol. 22:212-222.
11. Vincent, A., G. K. Scadding, H. C. Thomas, and J. Newsom-Davis. 1978. In vitro synthesis of anti-acetylcholine-receptor antibody by thymic lymphocytes in myasthenia gravis. Lancet. 1:305-307.
12. Lisak, R. P., A. I. Levinson, B. Zweiman, and M. J. Kornstein. 1986. Antibodies to acetylcholine receptor and tetanus toxoid: in vitro synthesis by thymic lymphocytes. J. Immunol. 137:1221-1225.
13. Newsom-Davis, J., N. Willcox, and L. Calder. 1981. Thymus cells in myasthenia gravis selectively enhance production of anti-acetylcholine-receptor blood lymphocytes. N. Engl. J. Med. 305:1313-1318.
14. Melms, A., B. C. G. Schalke, T. Kirchner, H. K. Müller-Hermelink, E. Albert, and H. Wekerle. 1988. Thymus in myasthenia gravis: isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients. J. Clin. Invest. 81:902-908.
15. Sommer, N., N. Willcox, G. C. Harcourt, and J. Newsom-Davis. 1990. Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor specific T cells. Ann. Neurol. 28:312-319.
16. Bosma, G. C., R. P. Custer, and M. Bosma. 1983. A severe combined immunodeficiency mutation in the mouse. Nature (Lond.). 301:527-530.
17. McCune, J. M., R. Namikawa, H. Kaneshima, L. D. Schultz, M. Lieberman, and I. L. Weissman. 1988. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science (Wash. DC). 241:1632-1639.
18. Mosier, D. E., R. J. Gulizia, S. Baird, and D. B. Wilson. 1988. Transfer of functional human immune system to mice with severe combined immunodeficiency. Nature (Lond.). 335:256-259.
19. Bosma, G. C., M. Fried, R. P. Custer, A. Carroll, D. M. Gibson, and M. Bosma. 1988. Evidence of functional lymphocytes in some (leaky) SCID mice. J. Exp. Med. 167:1016-1033.
20. Levy, R., B. Czeraobilsky, and B. Geiger. 1988. Subtyping of epithelial cells of normal and metaplastic human uterine cervix, using polypeptide-specific cytokeratin antibodies. Differentiation. 39:185-196.
21. McFarland, E. J., R. M. Scearce, and B. F. Haynes. 1984. The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment. J. Immunol. 133:1241-1249.
22. Haynes, B. F., R. M. Scearce, D. F. Lobach, and L. L. Hensley. 1984. Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment. J. Exp. Med. 159:1149-1168.
23. Lindstrom, J. M., M. E. Seybold, V. A. Lennon, S. Whittingham, and D. D. Duane. 1976. Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value. Neurology. 26:1054-1059.
24. Barry, T. S., D. M. Jones, C. B. Richter, and B. F. Haynes. 1991. Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens. J. Exp. Med. 173:167-180.
25. Toyka, K. V., D. B. Drachman, A. Pestronk, and I. Kao. 1975. Myasthenia gravis: passive transfer from man to mouse. Science (Wash. DC). 190:397-399.
26. Lieber, M. R., J. E. Hesse, S. Lewis, G. C. Bosma, N. Rosenberg, M. Mizuuchi, M. J. Bosma, and M. Gellert. 1988. The defect in murine severe combined immune deficiency: joining of signal consequences but not coding sequences in V(D)J recombination. Cell. 55:7-16.
27. Duchosal, M. A., P. J. McConahey, C. A. Robinson, and F. J. Dixon. 1990. Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice. J. Exp. Med. 172:985-988.
28. Macht, L., N. Fukuma, K. Leader, D. Sarsero, C. A. S. Pegg, D. I. W. Phillips, P. Yates, S. M. McLachlan, C. Elson, and B. Rees Smith. 1991. Severe combined immunodeficient (SCID) mice: a model for investigating human thyroid autoantibody synthesis. Clin. Exp. Immunol. 84:34-42.
29. Vandekerckhove, B. A. E., J. F. Krowka, J. M. McCune, J. E. De Vries, H. Spits, and M. G. Roncarolo. 1991. Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse. J. Immunol. 146:4173-4179.
30. Berman, P. W. and J. Patrick. 1980. Experimental myasthenia gravis. A murine system. J. Exp. Med. 151:204-223.