Biological Activities and Quantitative Structure-Activity Relationships of Spiro[imidazolidine-4,4′(1′H)-quinazoline]-2,2′,5(3′H)-triones as Aldose Reductase Inhibitors

Journal of Medicinal Chemistry

Volumn 35, Issue 11, 1992, Pages 2085-2094

  Yamagishi, Masafumi ^a,b   Yamada, Yoshihisa ^a,b   Ozaki, Ken ichi ^a,b   Asao, Masaaki ^a,b   Shimizu, Ryo ^a,b   Suzuki, Mamoru ^a,b   Matsumoto, Mamoru ^a,b   Matsuoka, Yuzo ^a,c   Matsumoto, Kazuo ^a,b  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b Research Laboratory of Applied Biochemistry   (Japan)

^c Biological Research Laboratory ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6' CHLORO 3' METHYLSPIRO[IMIDAZOLIDINE 4,4' (1'H) QUINAZOLINE] 2,2',5(3'H) TRIONE; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; HALOGEN; POLYOL; SPIRO COMPOUND; SPIRO[IMIDAZOLIDINE 4,4' (1'H) QUINAZOLINE] 2,2',5(3'H) TRIONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATARACT; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DRUG ACCUMULATION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; SCIATIC NERVE; STEREOCHEMISTRY; TOXICITY;

ALDEHYDE REDUCTASE; ANIMALS; IMIDAZOLES; IMIDAZOLIDINES; LENS, CRYSTALLINE; MALE; MATHEMATICS; MICE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; POLYMERS; QUINAZOLINES; RABBITS; RATS; RATS, INBRED STRAINS; SCIATIC NERVE; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0026645207     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00089a021     Document Type: Article

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