Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease

Journal of Clinical Periodontology

Volumn 19, Issue 9, 1992, Pages 687-692

  Norling, Tomas ^a   Lading, Pia ^b   Engström, Sven ^c   Larsson, Kåre ^c   Krog, Niels ^d   Nissen, Søren Søe ^a  

^a A L Inc ^*  (Denmark)

^b A L Laboratories   (United States)

^c LUND UNIVERSITY   (Sweden)

^d NONE   (Denmark)

Author keywords

biodegradation; controlled release; drug delivery system; liquid crystalline phases; metronidazole; monoglycerides; on site curing; periodontal disease

Indexed keywords

METRONIDAZOLE; TRIACYLGLYCEROL;

CALORIMETRY; CONFERENCE PAPER; CRYSTALLIZATION; DENTISTRY; DISSOLUTION; DRUG FORMULATION; DRUG RELEASE; SUSPENSION; SUSTAINED RELEASE PREPARATION; X RAY DIFFRACTION;

BIODEGRADATION; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG DESIGN; DRUG IMPLANTS; GELS; GLYCERIDES; HUMAN; METRONIDAZOLE; PERIODONTAL DISEASES; SESAME OIL; SOLUBILITY; SYRINGES; TEMPERATURE; VISCOSITY; X-RAY DIFFRACTION;

EID: 0026641726     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.1992.tb02529.x     Document Type: Article

References (29)

1. The development and clinical use of acrylic strips containing anti‐microbial agents in the management of chronic periodontitis
2. Lysosomal enzymes
3. Tetracycline and periodontal therapy
4. Use of strips containing tetracycline hydrochloride or metronidazole for the treatment of advanced periodontal disease
5. Drug delivery from cubic and other lipid‐water phases
6. New sustained release dosage form of chlorhexidine for dental use (1). Development and kinetics of release
7. Antibiotic in the treatment of human periodontal disease
8. Sustained release device containing metronidazole for periodontal use
9. Periodontal therapy by local delivery of tetracycline
10. A 4 quadrant comparative study of periodontal treatment using tetracycline‐containing drug delivery fibers and scaling
11. Microbial aetiology of periodontal disease
12. Food emulsifiers and their associations with water
13. Two cubic phases in monolein‐water system
14. The cubic phases of monoglyceride‐water systems. Arguments for a structure based upon lamellar bilayer units
15. Aqueous lipid phases of relevance to intestinal fat digestion and absorption
16. Effect of tetracycline and/or scaling on human periodontal disease. Clinical, microbiological, and histological observations
17. A bicontinuous tetrahedral structure in a liquid crystalline lipid
18. Experimental gingivitis in man
19. X‐ray diffraction studies of lipid‐water systems
20. La structure des colloïdes d'association. I. Les phases liquidecristallines des system amphiphile‐eau
21. Periodontal therapy in humans. I. Microbiological and clinical effects of a single course of periodontal scaling and root planing and of adjunctive tetracycline therapy
22. The physical chemistry of lipids: From alkanes to phospholipids
23. Microbiology and periodontal disease — present status and future considerations
24. A study of bacteria associated with advancing periodontitis in man