Hepatocarcinogenicity of Dehydroepiandrosterone in the Rat

Cancer Research

Volumn 52, Issue 10, 1992, Pages 2977-2979

  Sambasiva Rao, M ^a   Subbarao, V ^a   Yeldandi, Anjana V ^a   Reddy, Janardan K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE TRANSFERASE; PRASTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER PREVENTION; CONTROLLED STUDY; DIET; HORMONAL CARCINOGENESIS; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LONG TERM EXPOSURE; MALE; MITOSIS INHIBITION; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; RAT;

ANIMAL; ANTICARCINOGENIC AGENTS; BODY WEIGHT; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICROBODIES; ORGAN WEIGHT; PRASTERONE; RATS; RATS, INBRED F344; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026638358     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Schwartz, A. G., Whitcomb, J. M., Nyce, J. W., Lewbart, M. L., and Pashko, L. L. Dehydroepiandrosterone and structural analogs: a new class of cancer chemopreventive agents. Adv. Cancer Res., 51:391-423, 1988.
2. Boone, C. W., Kellogg, A. J., and Malone, W. E. Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review. Cancer Res., 50:2-9, 1990.
3. Gordon, G. B., Shautz, L. M., and Talalay, P. Modulation of growth, differentiation and carcinogenesis by dehydroepiandrosterone. Adv. Enzyme Regul., 26:255-382, 1987.
4. Frenkel, R. A., Slaughter, C. A., Orth, K., Moomaus, C. R., Hicks, S. H., Snyder, J. M., Bennett, M., Prough, R. A., Putnam, R. S., and Milewich, L. Peroxisome proliferation and induction of peroxisomal enzymes in mouse and rat liver by dehydroepiandrosterone feeding. J. Steroid Biochem., 35: 333-342, 1990.
5. Rao, M. S., Musunuri, S., and Reddy, J. K. Dehydroepiandrosterone-induced peroxisome proliferation in the rat liver. Pathobiology, 60: 82-86, 1992.
6. Yamada, J., Sukuma, M., Ikeda, T., Fukuda, K., and Suga, T. Characteristics of dehydroepiandrosterone as a peroxisome proliferator. Biochim. Biophys. Acta, 1092: 233-243, 1991.
7. Wu, H., Masset-Brown, J., Tweedie, D. J., Milewich, L., Frenkel, R. A., Martin-Wixtrom, C., Estabrook, R. W., and Prough, R. A. Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVAI (P-450 LAW) by dehydroepiandrosterone in rats: a possible peroxisome proliferator. Cancer Res., 49: 2337-2343, 1989.
8. Reddy, J. K., and Lalwani, N. D. Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC Crit. Rev. Toxicol., 12: 1-53, 1983.
9. Rao, M. S., and Reddy, J. K. Toxicological implications of peroxisome proliferation. In: R. Meeks, S. Harrison, and J. Bull (eds.), Hepatotoxicology, pp. 621-646. Boca Raton, FL: CRC Press, Inc., 1991.
10. Reddy, J. K., and Rao, M. S. Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis. Mutat. Res., 214: 63-68, 1989.
11. Butterworth, B. E., Loury, D. J., Smith-Oliver T., and Cattley, R. S. The potential role of chemically induced hyperplasia in the carcinogenic activity of the hypolipidemic carcinogens. Toxicol. Ind. Health, 3: 129-146, 1987.
12. Kraupp-Grasl, B., Huer, W., Taper, H., and Schulte-Herman, R. Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously. Cancer Res., 51:666-671,1991.
13. Schwartz, A. G. Inhibition of spontaneous breast cancer formation in female C3HAVY/a mice by long term treatment with dehydroepiandrosterone. Cancer Res., 39: 1129-1132, 1979.
14. Rao, M. S., Tatematsu, M., Subbarao, V., Ito, N., and Reddy, J. K. Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione 5-transferase and 7-glutamyltrans-peptidase. Cancer Res., 46:5287-5290,1986.
15. Farber, E. Pre-cancerous steps in carcinogenesis: their physiological adaptive nature. Biochim. Biophys. Acta, 738: 171-180, 1984.
16. Rao, M. S., and Reddy, J. K. Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis (Lond.), 8:631-636, 1987.
17. Reddy, J. K., Goel, S. K., Nemali, M. R., Carrino, J., Laffler, T. A., Reddy, M. K., Sperbeck, S. J., Ozumi, T., Hashimoto, T., Lalwani, N. D., and Rao, M. S. Transcriptional regulation of peroxisomal fatty acyl-COA oxidase and enoyl-Coa hydratase/3hydroxyacyl-Coa dehydrogenase in rat liver by peroxisome proliferators. Proc. Natl. Acad. Sci. USA, 83:747-751, 1986.
18. Isseman, I., and Green, S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature (Lond)., 347:645-650, 1990.
19. Reddy, J. K., Reddy, M. K., Usman, M. I., and Lalwani, N. D., and Rao, M. S. Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl)phthalate, and di(2-ethylhexyl)adipate with a hypolipidemic drug. Environ. Health Per-spect., 65:317-327, 1986.
20. Yokoyama, Y., Tsuchida, S., Hatayama, I., Satoh, K., Narita, T., Rao, M. S., Reddy, J. K., Yamada, J., Suga, T., and Sato, K. Loss of peroxisomal enzyme expression in preneoplastic and neoplastic lesions induced by peroxisome proliferators in rat livers. Carcinogenesis (Lond.), 13: 265-269,1992.
21. Loeb, L. A. Endogenous carcinogenesis: molecular oncology into the twenty-first century-Presidential Address. Cancer Res., 49:5489-5496,1989.