Phenylacetate: A Novel Nontoxic Inducer of Tumor Cell Differentiation

Cancer Research

Volumn 52, Issue 7, 1992, Pages 1988-1992

  Sherman, Lin Ti ^b   Shack, Sonsoles ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; PHENYLACETIC ACID;

ARTICLE; CARDIOVASCULAR EFFECT; CELL DIFFERENTIATION; DRUG CYTOTOXICITY; DRUG EFFECT; GENE EXPRESSION; HUMAN; HUMAN CELL; ONCOGENE MYC; PRIORITY JOURNAL; TUMOR DIFFERENTIATION;

ADIPOSE TISSUE; ANIMAL; ANTINEOPLASTIC AGENTS; AZACITIDINE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION; GENES, MYC; HUMAN; LEUKEMIA, PROMYELOCYTIC, ACUTE; MICE; MICE, NUDE; PHENYLACETATES; RNA, RIBOSOMAL; SUPPORT, NON-U.S. GOV'T;

EID: 0026636474     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. James, M. O., SmiUi, R. L., WiUiams, F. R. S., and Reidenberg, M. The conjugation of phenylacetic acid in man, sub-human primates and some nonprimate species. Proc. R. Soc. Lond. B., 182:25-35, 1972.
2. BrusUow, S. W., Danney, M., Waber, L. J., Batshaw, M., Burton, B., Levitsky, L., Roth, K., McKeethren, C., and Ward, J. Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis. N. Engl. J. Med., 310:1630-1634,1984.
3. Simell, O., Sipila, I., Rajantie, J., Valle, D. L., and Brusuow, S. W. Waste nitrogen excretion via amino acid acylation: benzoate and phenyhicetate in lysinuric protein intolerance. Pediatr. Res., 20:1117-1121, 1986.
4. MendenhaU, C. L., Rouster, S., Marshall, L., and Weesner, R. A new therapy for portal systemic encephalopathy. Am. J. Gastroenterol., 81: 540-543, 1986.
5. Weber, G. Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture. Cancer Res., 43:3466-3492,1983.
6. Medina, M. A., Sanchez-Jimenez, F., Marquez, F. J., Perez-Rodriguez, J., Quesada, A. R., and Nunez de Castro, I. Glutamine and glucose as energy substrates for ehrlich ascites tumor cells. Biochem. Int., 16:339-347,1988.
7. Rosenfeld, H., and Roberts, J. Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-l-norleudne and acivicin in cell culture by glutaminase-asparaginase. Cancer Res., 41:1324-1328,1981.
8. Neish, W. J. P. Phenylacetic acid as a potential therapeutic agent for the treatment of human cancer. Experientia (Basel), 27:860-861,1971.
9. Kitoh, T., Kubota, M., Takimoto, T., Hashimoto, H., Shimizu, T., Sano, H., Akiyama, V., and Mikawa, H. Metabolic basis for differential glutamine requirements of human leukemia cell lines. J. Cell. Physiol., 143: 150-153, 1990.
10. Imaizumi, M., and Breitman, T. R. Retinoic acid-induced differentiation of the human promyelocytic leukemia cell line, HL-60, and fresh human leukemia cells in primary culture: a model for differentiation inducing therapy of leukemia. Eur. J. Haematol., 38:289-302, 1987.
11. Wier, M. L., and Scott, R. E. Aproliferin-a human plasma protein that induced the irreversible loss of proliferative potential associated with terminal differentiation. Am. J. Pathol., 125:546-554, 1986.
12. Rimoldi, D., Srikantan, V., Wilson, V. L., Bassin, R. H., and Samid, D. Increased sensitivity of nontumorigenic fibroblasts expressing ras or myc oncogenes to malignant transformation induced by 5-aza-2'-deoxycytidine. Cancer Res., 51:1-7, 1991.
13. Bemlohr, D. A., Angus, C. W., Lane, M. D., Bolanowski, M. A., and Kelly, T. J., Jr. Expression of specific mRNA during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein. Proc. Nad. Acad. Sci. USA, 81:5468-5472,1984.
14. Cowan, E. P., Jordan, B. R., and Coligan, J. E. Molecular cloning and DNA sequence analysis of genes encoding cytotoxic T lymphocyte-defined HLA-A3 subtypes: the El subtype. J. Immunol., 135:2835-2841,1985.
15. Konieczny, S. F., and Emerson, C. P., Jr. 5-Azacytidine induction of suble mesodermal stem cell lineages from ICn'Vz Cells: evidence for regulatory genes controlling determination. Cell, 38:791-800,1984.
16. Ailhaud, G., Dani, C., Amri, E-Z., Djian, P., Vannier, C., Doglio, A., Forest, C., Gaillard, D., Negrel, R., and Grimaldi, P. Coupling growth arrest and adipocyte differentiation. Environ. Health Prespect, 80:17-23, 1989.
17. Nuti, M. P., De Bertoldi, M., and Lepidi, A. A. Influence of phenylacetic add on poly-ß-hydrobutyrate polymerization and cell elongation in Asobacter chroococaim Beij. Can. J. Microbiol., 18:1257-1261,1972.
18. Kishore, G., Sugumaran, M., and Vaidyanathan, C. S. Metabolism of d., l-pbenylanine by Aspergillus niger. J. Bacteriol., 128:182-191,1976.
19. Wightman, F., and Lighty, D. L. Identification of phenylacetic acid as a natural auxin in the shoots of higher plants. Physiol. Phmt, 55:17-24,1982.
20. Nichols, K. E., and Weinberg, J. B. Essential amino acid deprivation induces monocytic differentiation of the human HL-60 myeloid leukemia cell line. Blood, 73:1298-1306,1989.
21. Nichols, K. E., Chitneni, S. R., Moore, J. O., and Weinberg J. B. Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells induced by the glutamine antagonist acivicin. Blood, 74: 1728-1737, 1989.
22. Weinberg, J. B., and Mason, S. N. Relationship of acivicin-induced monocytic differentiation of human myeloid leukemia cells to acivicin-induced modulation of growth factor, cytokine, and protooncogene mRNA expression. Cancer Res., 51:1201-1209,1991.
23. Hammerling, G. J., Klar, D., Pulm, W., Momburg, F., and Moldenhauer, G. The influence of nuyor histocompatibility complex class I antigens on tumor growth and metastasis. Biochim. Biophys. Acta, 907:245-259,1987.
24. Vanjusin, B. F., Bashkite, E. A., Friedrich, A., and Chvojka, L. Metilirovanie DNK v porostkach psenicy i vlyanije fytogormonov. Biochemia, 46:47-53, 1981.