ras-Induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

Cell

Volumn 70, Issue 1, 1992, Pages 153-161

  Lu, Xin ^a   Park, Sang Hee ^b   Thompson, Timothy C ^b   Lane, David P ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b EAST TEXAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEIN P53;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL GROWTH; CELL HYPERPLASIA; CELL LINE; CELL TRANSFORMATION; CONTROLLED STUDY; FETUS; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; GROWTH INHIBITION; MALE; MOUSE; NONHUMAN; ONCOGENE MYC; ONCOGENE RAS; PLASMID; PRIORITY JOURNAL; PROSTATE; TUMOR SUPPRESSOR GENE;

ANIMAL; BASE SEQUENCE; CARCINOMA; COMPARATIVE STUDY; DNA DAMAGE; GENES, MYC; GENES, RAS; HYPERPLASIA; MALE; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PROSTATIC NEOPLASMS; PROTEIN P53; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0026636158     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(92)90541-J     Document Type: Article

References (40)

1. Suppression of human colorectal carcinoma cell growth by wild-type p53
2. Isolation of human p53 specific monoclonal antibodies and their use in the studies of human p53 expression
3. Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines
4. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies
5. Archival analysis of p53 genetic and protein alteration in chinese esophageal cancer
6. Ability of p53 and the adenovirus E1 b 58-kilodalton protein to form a complex is determined by p53
7. Growth suppression of human breast cancer cells by the introduction of a wild type p53 gene
8. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors
9. p53 and DNA polymerase a compete for binding to SV40 T antigen
10. Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form
11. Cooperation between oncogenes
12. Increased expression of mutant forms of p53 oncogene in primary lung cancer
13. Expression of wild type p53 is not compatible with continued growth of p53-negative tumor cells
14. Participation of p53 protein in the cellular response to DNA damage
15. Tumorigenic conversion of primary embryo fibroblasts require at least two cooperating oncogenes
16. p53: oncogene or anti-oncogene?
17. Monoclonal antibody analysis of the SV40 large T antigen-p53 complex
18. Cooperative transforming activity of ras, myc, and src viral oncogenes in non-established rat adrenocortical cells
19. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
20. Tumor suppressor genes
21. Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction
22. p53 mutations in ovarian cancer: a late event?
23. Elevated TGF-p1 and β3 mRNA levels are associated with ras + myc induced carcinomas in reconstituted mouse prostate: evidence for a paracrine role during progression
24. Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in E. coli
25. Visualisation, by immunocytochemistry, of p53 at the plasma membrane of both nontransformed and SV40-transformed cells
26. A sensitive and quantitative enzyme-linked immunosorbence assay for the c-myc and N-myc oncoproteins
27. Mutations in the p53 gene occur in diverse human tumour types
28. Post translational regulation of the 54K cellular tumor antigen in normal and transformed cells
29. Rapid and sensitive detection of point mutations and DNA polymorphism using the polymerase chain reaction
30. The amino acid sequence of murine p53 determined from a cDNA clone
31. Regulation of the level of the oncoprotein p53 in nontransformed and transformed cells
32. Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells
33. Cloning and sequence analysis of the Saccharomyces cerevisiae RAD9 gene and further evidence that its product is required for cell cycle arrest induced by DNA damage
34. Clonal expansion of p53 mutant cells is associated with brain tumor progression
35. Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice synergistic action of oncogenes in vivo
36. Characterization of human p53 antigens employing primate specific monoclonal antibodies
37. Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ
38. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
39. Wild type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
40. Adenovirus serotype determines association and localisation of the large E1b tumor antigen with cellular tumor antigen p53 in transformed cells