Extraordinarily Potent Antimalarial Compounds: New, Structurally Simple, Easily Synthesized, Tricyclic 1,2,4-Trioxanes

Journal of Medicinal Chemistry

Volumn 35, Issue 13, 1992, Pages 2459-2467

  Posner, Gary H ^a,b   Oh, Chang Ho ^a,b   Gerena, Lucia ^a,b   Milhous, Wilbur K ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIOXANE DERIVATIVE; ALCOHOL DERIVATIVE; ANTIMALARIAL AGENT; ARTEMISININ; ARTEMISININ DERIVATIVE; CARBAMIC ACID ESTER; CHLOROQUINE; ESTER; ETHER DERIVATIVE; ORGANOPHOSPHATE; SULFONIC ACID DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG RESISTANCE; DRUG SENSITIVITY; DRUG SYNTHESIS; DRUG TRANSFORMATION; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMAL; ANTIMALARIALS; BICYCLO COMPOUNDS; DIOXINS; MICROBIAL SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0026635291     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00091a014     Document Type: Article

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