Identification of the Uncultured Bacillus of Whipple's Disease

New England Journal of Medicine

Volumn 327, Issue 5, 1992, Pages 293-301

  Relman, David A ^a   Schmidt, Thomas M ^b   Macdermott, Richard P ^c   Falkow, Stanley ^a  

^a STANFORD UNIVERSITY   (United States)

^b MIAMI UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RESTRICTION ENDONUCLEASE; RIBOSOME RNA; TISSUE EXTRACT;

ACTINOBACTERIA; ARTICLE; CELL INCLUSION; CLINICAL ARTICLE; CONTROLLED STUDY; DUODENUM; ELECTRON MICROSCOPY; ENDOSCOPIC BIOPSY; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE LIPODYSTROPHY; LYMPH NODE; MACROPHAGE; MALE; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYLOGENY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA SEQUENCE; SYMPTOM; TROPHERYMA WHIPPELII;

ACTINOBACTERIA; ADULT; BASE SEQUENCE; DUODENUM; HUMAN; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RNA, BACTERIAL; RNA, RIBOSOMAL, 16S; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; WHIPPLE'S DISEASE;

EID: 0026632826     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199207303270501     Document Type: Article

References (39)

1. Whipple GH. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp 1907; 18: 382–91.
2. Dobbins WO III. Whipple's disease. Springfield, Ill.: Charles C Thomas, 1987.
3. Fleming JL, Wiesner RH, Shorter RG. Whipple's disease: clinical, biochemical, and histopathologic features and assessment of treatment in 29 patients. Mayo Clin Proc 1988; 63: 539–51.
4. Chears WC Jr, Ashworth CT. Electron microscopic study of the intestinal mucosa in Whipple's disease: demonstration of encapsulated bacilliform bodies in the lesion. Gastroenterology 1961; 41: 129–38.
5. Yardley JH, Hendrix TR. Combined electron and light microscopy in Whipple's disease: demonstration of “bacillary bodies” in the intestine. Bull Johns Hopkins Hosp 1961; 109: 80–98.
6. Dobbins WO III, Kawanishi H. Bacillary characteristics in Whipple's disease: an electron microscopic study. Gastroenterology 1981; 80: 1468–75.
7. Silva MT, Macedo PM, Moura-Nunes JF. Ultrastructure of bacilli and the bacillary origin of the macrophagic inclusions in Whipple's disease. J Gen Microbiol 1985; 131: 1001–13.
8. Relman DA, Loutit JS, Schmidt TM, Falkow S, Tompkins LS. The agent of bacillary angiomatosis — an approach to the identification of uncultured pathogens. N Engl J Med 1990; 323: 1573–80.
9. Woese CR, Kandier O, Wheelis ML. Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. Proc Natl Acad Sci U S A 1990; 87: 4576–9.
10. Woese CR. Bacterial evolution. Microbiol Rev 1987; 51: 221–71.
11. Wilson KH, Blitchington R, Frothingham R, Wilson JAP. Phylogeny of the Whipple's-disease-associated bacterium. Lancet 1991; 338: 474–5.
12. Feldman M, Price G. Intestinal bleeding in patients with Whipple's disease. Gastroenterology 1989; 96: 1207–9.
13. Eden PA, Schmidt TM, Blakemore RP, Pace NR. Phylogenetic analysis of Aquaspirillum magnetotacticum using polymerase chain reaction-amplified 16S rRNA-specific DNA. Int J Syst Bacteriol 1991; 41: 324–5.
14. Bauer HM, Ting Y, Greer CE, et al. Genital human papillomavirus infection in female university students as determined by a PCR-based method. JAMA 1991; 265: 472–7.
15. Tracy TE, Mulcahy LS. A simple method for direct automated sequencing of PCR fragments. Biotechniques 1991; 11: 68–75.
16. Olsen GJ, Lane DJ, Giovannoni SJ, Pace NR, Stahl DA. Microbial ecology and evolution: a ribosomal RNA approach. Annu Rev Microbiol 1986; 40: 337–65.
17. Jukes TH, Cantor CR. Evolution of protein molecules. In: Munro HN, ed. Mammalian protein metabolism. Vol. 3. New York: Academic Press, 1969: 21–132.
18. Olsen GJ. Earliest phylogenetic branchings: comparing rRNA-based evolutionary trees inferred with various techniques. Cold Spring Harb Symp Quant Biol 1987; 52: 825–37.
19. Felsenstein J. Confidence limits on phytogenies: an approach using the bootstrap. Evolution 1985; 39: 783–91.
20. Olsen GJ, Larsen N, Woese CR. The ribosomal RNA database project. Nucleic Acids Res 1991; 19: Suppl: 2017–21.
21. Gupta S, Pinching AJ, Onwubalili J, Vince A, Evans DJ, Hodgson HJF. Whipple's disease with unusual clinical, bacteriologic, and immunologic findings. Gastroenterology 1986; 90: 1286–9.
22. Goodfellow M. Suprageneric classification of actinomycetes. In: Williams ST, Sharpe ME, Holt JG, eds. Bergey's manual of systematic bacteriology. Vol. 4. Baltimore: Williams & Wilkins, 1989:2333–9.
23. Stackebrandt E, Kroppenstedt RM, Fowler VJ. A phylogenetic analysis of the family Dermatophilaceae. J Gen Microbiol 1983; 129: 1831–8.
24. Collins MD, Dorsch M, Stackebrandt E. Transfer of Pimelobacter tumescens to Terrabacter gen. nov. as Terrabacter tumescens comb. nov. and of Pimelobacter jensenii to Nocardioides as Nocardioides jensenii comb. nov. Int J Syst Bacteriol 1989; 39: 1–6.
25. Stahl DA, Urbance JW. The division between fast- and slow-growing species corresponds to natural relationships among the mycobacteria. J Bacteriol 1990; 172: 116–24.
26. Williams ST, Sharpe ME, Holt JG, eds. Bergey's manual of systematic bacteriology. Baltimore: Williams & Wilkins, 1989.
27. Fox GE, Wisotzkey JD, Jurtshuk P Jr. How close is close: 16S rRNA sequence identity may not be sufficient to guarantee species identity. Int J Syst Bacteriol 1992; 42: 166–70.
28. Khavari PA, Bolognia JL, Eisen R, Edberg SC, Grimshaw SC, Shapiro PE. Periodic acidSchiffpositive organisms in primary cutaneous Bacillus cereus infection: case report and an investigation of the periodic acidSchiff staining properties of bacteria. Arch Dermatol 1991; 127: 543–6.
29. Clark JB. Morphogenesis in the genus Arthrobacter. CRC Crit Rev Microbiol 1972; 1: 521–44.
30. Luscombe BM, Gray TRG. Characteristics of Arthrobacter grown in continuous culture. J Gen Microbiol 1974; 82: 213–22.
31. Clancy RL, Tomkins WAF, Muckle TJ, Richardson H, Rawls WE. Isolation and characterization of an aetiological agent in Whipple's disease. BMJ 1975; 3: 568–70.
32. Gillin JS, Urmacher C, West R, Shike M. Disseminated Mycobacterium avium–intracellulare infection in acquired immunodeficiency syndrome mimicking Whipple's disease. Gastroenterology 1983; 85: 1187–91.
33. Strom RL, Gruninger RP. AIDS with Mycobacterium avium–intracellulare lesions resembling those of Whipple's disease. N Engl J Med 1983; 309: 1323–4.
34. Roth RI, Owen RL, Keren DF. AIDS with Mycobacterium avium–intracellulare lesions resembling those of Whipple's disease. N Engl J Med 1983; 309: 1324–5.
35. Cimprich RE, Rooney JR. Corynebacterium equi enteritis in foals. Vet Pathol 1977; 14: 95–102.
36. Wang HH, Tollerud D, Danar D, Hanff P, Gottesdiener K, Rosen S. Another Whipple-like disease in AIDS? N Engl J Med 1986; 314: 1577–8.
37. Cho C, Linscheer WG, Hirschkorn MA, Ashutosh K. sarcoid-like granulomas as an early manifestation of Whipple's disease. Gastroenterology 1984; 87: 941–7.
38. Southern JF, Moscicki RA, Magro C, Dickersin GR, Fallon JT, Bloch KJ. Lymphedema, lymphocytic myocarditis, and sarcoid-like granulomatosis: manifestations of Whipple's disease. JAMA 1989; 261: 1467–70.
39. Spapen HDM, Segers O, De Wit N, et al. Electron microscopic detection of Whipple's bacillus in sarcoid-like periodic acidSchiffnegative granulomas. Dig Dis Sci 1989; 34: 640–3.