The influence of nearest neighbors on the rate and pattern of spontaneous point mutations

Journal of Molecular Evolution

Volumn 34, Issue 3, 1992, Pages 189-200

  Blake, R D ^a   Hess, Samuel T ^a   Nicholson Tuell, Janice ^a  

^a UNIVERSITY OF MAINE   (United States)

Author keywords

CpG; Mutation pattern; Nearest neighbor effects; Pseudogenes; Substitution mutations; Transitions; Transversions

Indexed keywords

CYTOSINE DERIVATIVE; DNA DIRECTED DNA POLYMERASE ALPHA; PURINE; PYRIMIDINE; URACIL DNA GLYCOSYLTRANSFERASE;

ARTICLE; BASE PAIRING; DELETION MUTANT; GENE SEQUENCE; GENOME; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIMATE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PSEUDOGENE; SPONTANEOUS MUTATION;

ANIMAL; BASE COMPOSITION; BASE SEQUENCE; DNA; EVOLUTION; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; PSEUDOGENES; SEQUENCE ALIGNMENT; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

PRIMATES;

EID: 0026631005     PISSN: 00222844     EISSN: 14321432     Source Type: Journal    
DOI: 10.1007/BF00162968     Document Type: Article

References (48)

1. On the topography of the genetic fine structure
2. CpG-rich islands and the function of DNA methylation
3. Evolution and functional significance of the bias in codon usage
4. Mitochondrial DNA sequences of primates: tempo and mode of evolution
5. Principles of sequence-dependent flexure of DNA
6. An NMR structural study of deaminated base pairs in DNA
7. A bifurcated hydrogen-bonded conformation in the d(A · T) base pairs of the DNA dodecamer d(CGCAAATTTGCG) and its complex with distamycin
8. A set of lacZ mutations in Escherichia coli that allow rapid detection of specific frameshift mutations
9. Spontaneous deamination of cytosine and 5-methylcytosine residues in DNA and replacement of 5-methylcytosine residues with cytosine residues
10. Kinetic basis of spontaneous mutation. Misinsertion frequencies, proofreading specificities and cost of proofreading by DNA polymerases of E. coli
11. Random sequences
12. Uracil-DNA glycosylase activity affects the mutagenicity of ethylmethanesulfonate: evidence for an alternative pathway of alkylation mutagenesis
13. A sensitive genetic assay for the detection of rate constants and the activation energy
14. Mechanisms of spontaneous mutagenesis: clues from mutational specificity
15. Patterns of nucleotide substitution in pseudogenes and functional genes
16. Degrees of divergence in the E. coli genome from the correlation between dinucleotide, trinucleotide and codon frequencies
17. Structure of an adenine-cytosine base pair in DNA and its implications for mismatch repair
18. Repair of a mismatch is influenced by the base composition of the surrounding nucleotide sequence
19. Enzymatic synthesis of deoxyribonucleic acid. VIII. Frequencies of nearest neighbor base sequences in deoxyribonucleic acid
20. Evolution of protein molecules
21. Structural studies of DNA fragments: the G·T wobble base pair in A, B and Z DNA; the G·A base pair in B-DNA
22. The influence of neighboring base pairs upon base-pair substitution mutation rates
23. Primate η-globin DNA sequences and man's place among the great apes
24. Evolution of duplicate genes and pseudogenes
25. Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications
26. Evolution of DNA sequences
27. DNA repair enzymes
28. Rapid and sensitive protein similarity searches
29. Repair of single base-pair transversion mismatches of Escherichia coli in vitro: correction of certain A/G mismatches is dependent of dam methylation and host mutHLS gene functions
30. Nearest neighbor influences on DNA polymerase insertion fidelity
31. Specificity of mutagenesis resulting from the induction of the SOS system in the absence of mutagenic treatment
32. DNA mismatch correction
33. A general method applicable to the search for similarities in the amino acid sequence of two proteins
34. The structure of an oligo(dA)·oligo(dT) tract and its biological implications
35. Mismatch repair in E. coli
36. DNA methylation and gene function
37. Doublet frequency analysis of bacterial DNAs
38. The effect of the base sequence on the fine structure of the double helix
39. Molecular mechanism of base substitution mutations: from hydrogen bonding to molecular dynamics
40. Complementary base pairing and the origin of substitution mutations
41. Molecular basis for substitution mutations
42. Base sequence, local helix structure, and macroscopic curvature of A-DNA and B-DNA
43. Mismatch-specific thymine DNA-glycosylase and DNA polymerase β mediate the correction of G · T mispairs in nuclear extracts from human cells
44. Rapid similarity searches of nucleic acid and protein data banks
45. Inequality in mutation rates of the two strands of DNA