The p53 tumor‐suppressor gene and ras oncogene mutations in oral squamous‐cell carcinoma

International Journal of Cancer

Volumn 52, Issue 6, 1992, Pages 867-872

  Sakai, Eiki ^a   Rikimaru, Koichi ^a   Ueda, Masayoshi ^a   Matsumoto, Yukie ^a   Ishii, Naoko ^a   Enomoto, Shoji ^a   Yamamoto, Hajime ^a   Tsuchida, Nobuo ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUTH CARCINOMA; ONCOGENE RAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ADULT; AGED; BASE SEQUENCE; CARCINOMA, SQUAMOUS CELL; CODON; FEMALE; GENES, P53; GENES, RAS; HUMAN; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; MOUTH NEOPLASMS; MUTATION; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HYBRIDIZATION; POLYMERASE CHAIN REACTION; POLYMORPHISM (GENETICS); SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0026620901     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.2910520606     Document Type: Article

References (39)

1. ras genes
2. Frequent amplification of the bcl‐1 locus in head and neck squamous cell carcinomas
3. ras oncogenes in human cancer: a review
4. Ras mutations in United Kingdom examples of oral malignancies are infrequent
5. Mutations in the p53 gene are frequent in primary, resected non‐Small cell lung cancer
6. Transforming genes of human hematopoietic tumors: frequent detection of ras‐Related oncogenes whose activation appears to be independent of tumor phenotype
7. New human transforming genes detected by a tumorigenicity assay
8. Oral cancer and detection of patients and lesions at risk
9. Expression of oncogenes in human tumors with special reference to the head and neck recion
10. Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck
11. Elevated expression of the c‐Myc oncoprotein correlates with poor prognosis in head and neck squamous cell carcinoma
12. p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia
13. Generation of single‐Stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA‐DQA locus
14. Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53
15. p53 alteration is a common event in the spontaneous immortalization of primary BALB/C murine embryo fibroblasts
16. Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary nal cells: a comparison of the “hot spot” mutant phenotypes
17. A point mutation at codon 13 of the N‐ras oncogene in myelodysplastic syndrome
18. Increased expression of mutant forms of p53 oncogene in primary lung cancer
19. Optimization of PCRs
20. The p53 tumor suppressor gene
21. Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas
22. Human cancer and cellular oncogenes
23. Rapid and sensitive detection of point mutations and DNA polymorphism using the polymerase chain reaction
24. Gene amplification and overexpression of epidermal growth factor receptor in squamous cell carcinoma of the head and neck
25. Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line
26. Low incidence of ras oncogene activation in human squamous cell carcinomas
27. Primer‐Directed enzymatic amplification of DNA with a thermostable DNA polymerase
28. Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor‐Suppressor genes
29. Epidemiologic and intervention studies. Screening: cancer epidemiology: the Indian scene
30. High frequency mutation in codons 12 and 61 of H‐ras oncogene in chewing‐Tobacco‐ related human oral carcinoma in India
31. Oncogene amplification in squamous cell carcinoma of the oral cavity
32. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines
33. The E6 oncoprotein encoded by human papillomavirus type 16 and 18 promotes the degradation of p53
34. Human immunodeficiency viral DNA is readily found in lymphnode biopsies from seropositive individuals
35. Amplification of the int‐2 gene in human head and neck squamous cell carcinomas
36. Activation of oncogenes in human oral cancer cells: a novel codon 13 mutation of c‐H‐ras gene and concurrent amplification of c‐Erb B‐1 and c myc‐
37. A dot‐Blot screening procedure for mutated ras oncogene using synthetic oligodeoxynucle‐ otides
38. High incidence of amplification of the epidermal growth factor receptor gene in human squamous cell carcinoma cell lines