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Volumn 33, Issue 50, 1993, Pages 7663-7666

Marinone and debromomarinone: Antibiotic sesquiterpenoid naphthoquinones of a new structure class from a marine bacterium

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; ANTIBIOTIC AGENT; DEBROMOMARINONE; MARINONE; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0026620004     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(93)88010-G     Document Type: Article
Times cited : (97)

References (18)
  • 10
    • 84918761453 scopus 로고    scopus 로고
    • The bacterium, isolate CNB-632, was obtained by serial dilution and plating techniques, using media containing rifampicin (5 gm/ml), from a sediment sample collected at the Torrey Pines Estuary, La Jolla, CA in 1989. The isolate was cultured in a marine medium (A1) consisting of 1% starch, 0.4% yeast extract, 0.2% peptone, 75% seawater, 25%, deionized water, buffered with 10 ml 1.0 M Tris buffer and shaken at 230 RPM for 7 days at 23°C. The whole culture was extracted with EtOAc to leave an extract from which compounds 1 (2–5 mg/L) and 2 (7–10 mg/L) were isolated. Isolate CNB-632 is an actinomycete which shows brown vegetative mycelia and lacks aerial spores and hyphae (A1 medium).
  • 11
    • 84918713239 scopus 로고    scopus 로고
    • 3OD) δ 6.10 (s, 1H), 5.95 (d, J = 5 Hz, 1H), 5.03 (bt, J = 7 Hz, 1H), 3.40 (br, 1H), 2.0 (m, 5H), 1.66 (bs, 3H), 1.60 (bs, 3H), 1.5 (m, 2H), 1.55 (bs, 3H), 1.45 (s, 3H).
  • 12
    • 84918745445 scopus 로고    scopus 로고
    • 13C NMR: see table.
  • 15
    • 84918710310 scopus 로고    scopus 로고
    • 3) δ 12.0 (s, 1H), 7.15 (d, J = 2.5 Hz, 1H), 6.55 (d, J = 2.5 Hz, 1H), 6.07 (d, J = 5.5, 1H), 5.02 (bt, J = 5.5 Hz, 1H), 3.46 (bt, J = 5 Hz, 1H), 2.0 (m, 5H), 1.88 (ddd, J = 3,6.5, 12 Hz, 1H), 1.68 (bs, 3H), 1.65 (m, 2H), 1.62 (bs, 3H), 1.56 (bs, 3H), 1.54 (s, 3H), 1.34 (m, 1H).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.