Ser-752 → Pro mutation in the cytoplasmic domain of integrin β3 subunit and defective activation of platelet integrin α(IIb)β3 (glycoprotein IIb- IIIa) in a variant of Glanzmann thrombasthenia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 89, Issue 21, 1992, Pages 10169-10173

  Chen, Y P ^a   Djaffar, I ^a   Pidard, D ^a   Steiner, B ^a   Cieutat, A M ^a   Caen, J P ^a   Rosa, J P ^a  

^a HÔPITAL LARIBOISIÈRE   (France)

Author keywords

Arg Gly Asp; fibrinogen receptor; molecular genetics; polymerase chain reaction

Indexed keywords

ADENOSINE DIPHOSPHATE; CHYMOTRYPSIN A; FIBRINOGEN; FIBRINOGEN RECEPTOR; INTEGRIN; THROMBIN; MESSENGER RNA; MONOCLONAL ANTIBODY; OLIGODEOXYRIBONUCLEOTIDE; PROLINE; SERINE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CASE REPORT; CONTROLLED STUDY; GENETIC ANALYSIS; GLANZMANN DISEASE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PHENOTYPE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; RECEPTOR BINDING; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; BLOOD; FEMALE; GENETIC VARIABILITY; GENETICS; ISOLATION AND PURIFICATION; MACROMOLECULE; MALE; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MUTATION; PEDIGREE;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CASE REPORT; CHROMATOGRAPHY, AFFINITY; FEMALE; FIBRINOGEN; HUMAN; MACROMOLECULAR SYSTEMS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; OLIGODEOXYRIBONUCLEOTIDES; PEDIGREE; PLATELET ACTIVATION; PLATELET MEMBRANE GLYCOPROTEINS; POLYMERASE CHAIN REACTION; PROLINE; RNA, MESSENGER; SERINE; SUPPORT, NON-U.S. GOV'T; THROMBASTHENIA; VARIATION (GENETICS);

EID: 0026614923     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.89.21.10169     Document Type: Article

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