VH‐Gene Representation in Autoantibodies Reflects the Normal Human B‐Cell Repertoire

Immunological Reviews

Volumn 128, Issue 1, 1992, Pages 101-122

  Stewart, A K ^a   Huang, C ^b   Long, A A ^a   Stollar, B D ^b   Schwartz, R S ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULINS, HEAVY CHAIN;

ADULT; AMINO ACID SEQUENCE; B LYMPHOCYTE; BIOLOGICAL MODEL; FETUS; GENE EXPRESSION; GENE REARRANGEMENT; GENETICS; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MOLECULAR GENETICS; POLYMERASE CHAIN REACTION; REVIEW; SEQUENCE ALIGNMENT; AUTOIMMUNITY; ETIOLOGY; HUMAN CELL; PRIORITY JOURNAL; SOMATIC MUTATION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AMINO ACID SEQUENCE; AUTOANTIBODIES; B-LYMPHOCYTE SUBSETS; FETUS; GENE EXPRESSION; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOGLOBULINS, HEAVY-CHAIN; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026612980     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1992.tb00834.x     Document Type: Article

References (77)

1. Restricted Ig H Chain V‐Gene usage in the human antibody response to haemophilus‐influenzae type b capsular polysaccharide
2. Somatic diversification of immunoglobulin heavy chain VDJ genes Evidence for somatic gene conversion in rabbits
3. Content and organization or the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus
4. Two induced anti‐Z‐DNA monoclonal antibodies use VH gene segments related to those of anti‐DNA autoantibodies
5. Immunoglobulin heavy chain variable region genes expressed by B cells in rheumatoid synovium
6. Analysis of variable region genes encoding a human anti‐DNA antibody of normal origin
7. Natural autoreactive and polyreae‐tive antibodies differing from antigen‐induced antibodies in the H‐chain CDR3
8. Characterization of two Ig VH genes which are homologous to human rheumatoid factors
9. A 16/6 idiotype‐positive anti‐DNA antibody is encoded by a conserved VH gene with no somatic mutation
10. A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody‐associated Vh genes
11. The early expression of some human autoantibody‐associated heavy chain variable region genes is controlled by specific regulatory elements
12. A segment of VH gene locus is duplicated
13. In vitro production of an anti‐DNA idiotype by lymphocytes of normal subjects and patients with systemic lupus erythematosus
14. Molecular characterization of a somatically mutated anti‐DNA antibody bearing two systemic lupus erythematosus‐related idiotypes
15. The recurrent expression of variable region segments in human IgM anti‐DNA autoantibodies
16. Relationship of human variable region heavy chain germ‐line genes to genes encoding anti‐DNA autoantibody
17. Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity
18. Recurrent utilization of genetic elements in V‐regions of antinucleic acid antibodies from autoimmune mice
19. V region sequences of anti‐DNA and anti‐RNA autoantibodies from NZB/NZW Fi mice
20. The VH gene sequences of anti‐DNA antibodies in two different strains of lupus‐prone mice are highly related
21. VH gene analysis ot spontaneously activated B‐cells in adult MRL‐lpr/lpr mice J558 bias is not limited to classic lupus autoantibodies
22. Human immunoglobulin‐Vh and immunoglobulin‐Vk repertoire revealed by insitu hybridization
23. Individual Vh genes detected with oligonucleotide probes from the complementarity‐determining regions, γ
24. An autoantibody to single‐stranded DNA: Comparison of the three‐dimensional structure of the unliganded Fab and a deoxynucleotide‐Fab complex
25. Identification and sequence of the VH gene elements encoding a human anti‐DNA antibody
26. Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes
27. Construction of representative immunoglobulin region cDNA libraries from peripheral blood lymphocytes without in vitro stimulation
28. Detection of cross reactive anti‐DNA antibody idiotypes on tissue‐bound immunoglobulins from skin biopsies of lupus patients
29. Independent analysis of the 16/6 idiotype lupus model‐A role for an environmental factor
30. Anti‐DNA antibody idiotypes in systemic lupus erythematosus
31. Comparison of the fetal and adult functional B cell repertoires by analysis of VH gene family expression
32. VH gene family repertoire of resting B cells: Preferential use of D‐proximal families early in development may be due lo distinct B cell subsets
33. Relationship of the CD5 B‐cell to human tonsillar lymphocytes that express autoantibody‐associated cross‐reactive idiotypes
34. High frequency expression of a conserved kappa light chain variable region gene in chronic lymphocytic leukemia
35. Immunoglobulin Vμ; clan and family identity predicts variable domain structure and may influence antigen binding
36. Amino acid sequence of a platelet‐binding human anti‐DNA monoclonal autoantibody
37. Adult B‐ceil repertoire is biased toward two heavy‐chain variable‐region genes that rearrange frequently in fetal pre‐B cells
38. Autoantibodies encoded by the most JH‐proximal human immunoglobulin heavy chain variable region gene
39. High‐specificity insitu hybridization
40. Moiecular characteristics of antibodies bearing an anti‐DNA‐associated idiotype
41. IgG Anti‐DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection
42. Structure and multiplicity of genes for t he human immunoglobulin heavy chain variable region
43. The human cord blood antibody repertoire. Frequent usage of the VH7 gene family
44. A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus cry thematosus
45. Immunochemical similarities between monoclonal antibacterial Waldenstrom's macroglobulins and monoclonal anti‐DNA lupus autoantibodies
46. V region sequences of an idiotypically connected family of pathogenic anti‐DNA autoantibodies
47. Human immunoglobulin heavy‐chain variable region genes: organization, polymorphism, and expression
48. A human VH gene segment overrepresented in the autoimmune repertoire
49. The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from epstein‐Barr virus‐transformed B‐cells isolated from the synovial tissue of patients with rheumatoid arthritis Further evidence that some autoantibodies are unmutated copies of germ line genes
50. A hyperconversion mechanism generates the chicken light chain preimmune repertoire
51. Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions
52. Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families
53. VH sequence of a human anti‐Sm autoantibody. Evidence that autoantibodies can be unmutated copies of germline genes
54. Early restriction of the human antibody repertoire
55. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life
56. A novel class of anti‐DNA antibodies identified in BALB/c mice
57. Structure and function of anti‐DNA autoantibodies derived from a single autoimmune mouse
58. Anti‐DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
59. The detection of a common idiotype of anti‐DNA antibodies in the sera of patients with monoclonal gammopathies
60. Variable region diversity in human circulating antibodies specific for the capsular polysaccharide of haeniophilus‐imuenzae type‐B‐preferential usage of two types of VH3 heavy chains
61. Variable region primary structures of monoclonal anti‐DNA
62. Polymorphisms in human H chain V region genes from the VH III gene family
63. Cloning and sequence analysis of the VH and VL regions of an anti‐myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia
64. Autoantibodies and autoantigens‐A conserved system that may shape a primary immunoglobulin gene pool
65. Clonal persistence of lymphocytes‐B in normal mice is determined by variable region‐dependent selection
66. Eleven MRL‐lpr/lpr anti‐DNA autoantibodies are encoded by genes from four VH gene families: A potentially biased usage of VH genes
67. Structural characteristics of the variable regions of immunoglobulin genes encoding a pathogenic autoantibody in murine lupus
68. Somatic mutations in the variable regions of a human IgG anti‐double‐stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus
69. A deletion map of the human immunoglobulin heavy ehain variable region
70. The physical organization of the human immunoglobulin heavy chain gene complex
71. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood lymphocytes‐B
72. Preferential utilization of the most JH‐proximal VH gene segments in pre‐B‐cell lines
73. Molecular analysis of a germ line‐encoded idiotypic marker of pathogenic human lupus autoantibodies
74. Probing VH gene‐family utilization in human peripheral B‐cells by insitu hybridization