CP‐93,129, sumatriptan, dihydroergotamine block c‐fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges

British Journal of Pharmacology

Volumn 106, Issue 2, 1992, Pages 409-415

  Nozaki, Kazuhiko ^a   Moskowitz, Michael A ^a   Boccalini, Pia ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

5 HT1B D receptor agonists; CP 93,129; c fos expression; dihydroergotamine; heachache; subarachnoid haemorrhage; Sumatriptan; trigeminovascular system

Indexed keywords

3 (1,2,5,6 TETRAHYDROPYRID 4 YL)PYRROLO(3,2 B)PYRID 5 ONE; 3-(1,2,5,6-TETRAHYDROPYRID-4-YL)PYRROLO(3,2-B)PYRID-5-ONE; CAPSAICIN; CARRAGEENAN; DIHYDROERGOTAMINE; FORMALDEHYDE; INDOLE DERIVATIVE; PROTEIN C FOS; PROTO ONCOGENE PROTEINS C FOS; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; SULFONAMIDE; SUMATRIPTAN; 3 (1,2,5,6 TETRAHYDRO 4 PYRIDYL)PYRROLO[3,2 B]PYRIDIN 5 ONE; ENDOGENOUS COMPOUND; MORPHINE; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN AGONIST;

ANIMAL; ARTICLE; BIOSYNTHESIS; DRUG EFFECT; GENE EXPRESSION REGULATION; GUINEA PIG; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MENINX; METABOLISM; NOSE MUCOSA; PHYSIOLOGY; RAT; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONTROLLED STUDY; GENE EXPRESSION; HEADACHE; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NEWBORN; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; SUBARACHNOID HEMORRHAGE; TRIGEMINAL NUCLEUS;

ANIMAL; ANIMALS, NEWBORN; CAPSAICIN; CARRAGEENAN; DIHYDROERGOTAMINE; FORMALDEHYDE; GENE EXPRESSION REGULATION, NEOPLASTIC; GUINEA PIGS; IMMUNOHISTOCHEMISTRY; IN VITRO; INDOLES; MENINGES; NASAL MUCOSA; PROTO-ONCOGENE PROTEINS C-FOS; PYRIDINES; PYRROLES; RATS; SULFONAMIDES; SUMATRIPTAN;

EID: 0026611903     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1992.tb14348.x     Document Type: Article

References (28)

1. Dihydroergotamine and sumatriptan attenuate the increase in, plasma calcitonin gene related peptide levels within rat superior sagittal sinus during electrical trigeminal ganglion stimulation
2. 1 agonists for vascular headaches block endothelial, mast cell and platelet activation within dura mater after trigeminal stimulation
3. The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater
4. Further characterization of the putative 5‐HT receptor which mediates blockade of neurogenic plasma extravasation in rat dura mater
5. 1‐like receptor agonist
6. Subarachnoid haemorrhage in the rat: angiography and fluorescence microscopy of the major cerebral arteries
7. Ultrastructural evidence for neurogenically mediated changes in blood vessels of the rat dura mater and tongue following antidromic trigeminal stimulation
8. The selective carotid arterial vasoconstrictor action of GR43175 in anesthetised dogs
9. The antinocicecptive action of supraspinal opioids results from an increase in descending inhibitory control: correlation of nociceptive behaviour and c‐fos expression
10. Species difference in the pharmacology of terminal 5‐HT autoreceptors in mammalian brain
11. A rational approach to identifying a fundamentally new drug for the treatment of migraine
12. Induction of c‐fos‐like protein in spinal cord neurons following sensory stimulation
13. The time course of intracranial pathophysiological changes following experimental subarachnoid haemorrhage in the rat
14. 3‐(1,2,5,6‐Tetrahydropyrid‐4‐yi)pyrrolo[3,2‐b]pyrid‐5‐one: a potent and selective serotonin(5‐HT1B) agonist and rotationally restricted phenolic analogue of 5‐methoxy‐3‐(1,2,5,6‐tetrahydropyrid‐4‐yi) indole
15. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain
16. CP‐93,129, a potent and selective 5‐HT1B receptor agonist blocks neurogenic plasma extravazation within rat but not guinea‐pig dura mater
17. Spinal and trigeminal projections to the nucleus of the solitary tract: a possible substrate for somatovisceral and viscerovisceral reflex activation
18. 1B receptor
19. Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide: with detailed description of the the closed cranial window technique in rats
20. Neurobiology of vascular head pain
21. The visceral organ brain: implications for the pathophysiology of vascular head pain
22. Interpreting changes in vessel diameter in vascular headaches
23. Expression of c‐fos‐like immunoreactivity in brain stem after meningeal irritation by blood in the subarchnoid space
24. The pharmacology of current anti‐migraine drugs
25. Systemic morphine suppresses noxious stimulus‐evoked fos protein‐like immunoreactivity in rat spinal cord
26. Ergot alkaloids block neurogenic extravasation in dura mater: proposed action in vascular headaches
27. 1 binding sites, dilates arterioles and constrict arteriovenous anastomoses
28. Focal ischemia in rats causes time dependent expression of c‐fos protein immunoreactivity in widespread regions of ipsilateral cortex