New Vitamin D3 Derivatives with Unexpected Antiproliferative Activity: 1-(Hydroxymethyl)-25-hydroxyvitamin D3 Homologs

Journal of Medicinal Chemistry

Volumn 35, Issue 17, 1992, Pages 3280-3287

  Posner, Gary H ^a   Nelson, Todd D ^a   Guyton, Kathryn Z ^b   Kensler, Thomas W ^b  

^a Environmental Health Sciences Center   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXYMETHYLCALCIFEDIOL; CALCITRIOL; CALCITRIOL DERIVATIVE; UNCLASSIFIED DRUG; 1 ALPHA (HYDROXYMETHYL) 25 HYDROXYVITAMIN D3; 1 ALPHA-(HYDROXYMETHYL)-25-HYDROXYVITAMIN D3; 1 HYDROXYMETHYL 3 NORHYDROXY 3,25 DIHYDROXYVITAMIN D3; 1-HYDROXYMETHYL-3-NORHYDROXY-3,25-DIHYDROXYVITAMIN D3; CALBINDIN; CALCITRIOL RECEPTOR; CALCIUM BINDING PROTEIN, VITAMIN D DEPENDENT; DRUG DERIVATIVE; ORNITHINE DECARBOXYLASE; PHORBOL 13 ACETATE 12 MYRISTATE; STEROID RECEPTOR;

ANIMAL CELL; ARTICLE; CELL GROWTH; DIASTEREOISOMER; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING COMPETITION; BIOSYNTHESIS; CELL DIVISION; CELL LINE; CHEMICAL STRUCTURE; CHICK EMBRYO; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; DUODENUM; EMBRYOLOGY; METABOLISM; ORGAN CULTURE; STEREOISOMERISM; SYNTHESIS;

ANIMAL; BINDING, COMPETITIVE; CALCITRIOL; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CELL DIVISION; CELL LINE; CHICK EMBRYO; COMPARATIVE STUDY; DUODENUM; KERATINOCYTES; MICE; MOLECULAR STRUCTURE; ORGAN CULTURE; ORNITHINE DECARBOXYLASE; RECEPTORS, CALCITRIOL; RECEPTORS, STEROID; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, P.H.S.; TETRADECANOYLPHORBOL ACETATE;

EID: 0026611861     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00095a026     Document Type: Article

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