Protective effect of NG-nitro-l-arginine (N5[imino(nitroamino)methyl]-l-ornithine) against cyanide-induced convulsions in mice

Toxicology

Volumn 71, Issue 3, 1992, Pages 277-283

  Yamamoto, Hiro aki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Convulsions; Cyanide; Cyclic GMP; Guanylate cyclase inhibitor; NG nitro l arginine

Indexed keywords

ARGININE; CYANIDE; GUANYLATE CYCLASE; METHYLENE BLUE; N(G) NITROARGININE; DRUG DERIVATIVE; POTASSIUM CYANIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONVULSION; ENZYME INHIBITION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; IATROGENIC DISEASE; SEIZURE;

ANIMAL; ARGININE; MALE; METHYLENE BLUE; MICE; NITROARGININE; POTASSIUM CYANIDE; SEIZURES;

EID: 0026610131     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(92)90030-I     Document Type: Article

References (16)

1. Cyanides and their toxicity A literature review
2. Artifacts in the definition of toxicity by cyanides and cyanogens
3. The influence of hypoxia on the concentrations of cyclic nucleotides in the rat brain
4. Acute cyanide intoxication and central transmitter systems
5. Macrophage synthesis of nitrite, nitrate and n-nitrosamines: precursors and role of the respiratory burst
6. Cytokines induce an L-arginine-dependent effector system in nonmacrophage cells
7. Arginine is a physiological precursor of endothelium-derived nitric oxide
8. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation
9. 5-[imino (nitro-amino) methyl]-L-ornithine) impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from L-arginine
10. A simplified method of evaluating dose-effect experiments
11. Resolusion of thiosulfate interference in cyanide determination
12. Cyanide-induced neurotoxicity: role of neuronal calcium
13. Protection against cyanide-induced convulsions with α-ketoglutarate
14. Haem-dependent activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide: A unique transduction mechanism for transcellular signaling
15. Activation by a calcium-binding protein of guanylate cyclase in Tetrahymena Pyriformis