Discordance of the T-cell receptor alpha-chain gene in familial multiple sclerosis

Neurology

Volumn 42, Issue 4, 1992, Pages 839-844

  Lynch, Sharon G ^a   Rose, John W ^a   Petajan, Jack H ^a   Leppert, Mark ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; DNA; LYMPHOCYTE ANTIGEN RECEPTOR; RECEPTORS, ANTIGEN, T CELL, ALPHA BETA; CELL DNA; T LYMPHOCYTE RECEPTOR ALPHA CHAIN;

ALPHA CHAIN; ARTICLE; AUTOIMMUNITY; AUTOSOMAL DOMINANT DISORDER; AUTOSOMAL RECESSIVE DISORDER; CHROMOSOME POLYMORPHISM; ETIOLOGY; HAPLOTYPE; HUMAN; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PENETRANCE; PRIORITY JOURNAL; RESTRICTION FRAGMENT; ADULT; AGED; DOMINANT GENE; FEMALE; GENE; GENETIC LINKAGE; GENETICS; MALE; METABOLISM; NUCLEIC ACID HYBRIDIZATION; PEDIGREE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; CLINICAL ARTICLE; FAMILIAL DISEASE;

ADULT; AGED; DNA; FEMALE; GENES; GENES, DOMINANT; HAPLOTYPES; HUMAN; LINKAGE (GENETICS); MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGE; MULTIPLE SCLEROSIS; NUCLEIC ACID HYBRIDIZATION; PEDIGREE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.;

EID: 0026609572     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/wnl.42.4.839     Document Type: Article

References (32)

1. McFarlin DE, McFarland HF. Multiple sclerosis. N Engl J Med 1982;30:1183-1186.
2. Visscher BR, Detels R, Dudley J, et al. Genetic susceptibility to multiple sclerosis. Neurology 1979;29:1354-1360.
3. Spielman RS, Nathanson N. The genetics of susceptibility tomultiple sclerosis. Epidemiol Rev 1982;4:45-65.
4. Sadovnick AD, Baird PA, Ward RH. Updated risks for relatives. Am J Med Genet 1988;29:533-541.
5. Ebers GC, Bulmen DE, Sadovnick AD, et al. A population- based study of multiple sclerosis in twins. N Engl J Med 1986;315:1638-1642.
6. Williams A, Eldridge R, McFarland H, Houff S, Krebs H, McFarlin D. Multiple sclerosis in twins. Neurology 1980;30:1139-1147.
7. Hohlfeld R. Neurological autoimmune disease and the tri- molecular complex of T-lymphocytes. Ann Neurol 1989;25:531-538.
8. Govaerts A, Gony J, Martin-Mondiere C, et al. HLA and multiple sclerosis: population and families study. Tissue Antigens 1985;25:187-199.
9. Behlke MA, Chou HS, Huppi D, Loh DY. Murine T cell receptor mutants with deletions of beta chain variable region genes. Proc Natl Acad Sci USA 1986;83:767-771.
10. Zamvil SS, Mitchell DJ, Lee NE, et al. Predominant expression of a T cell receptor V, gene subfamily in autoimmune encephalomyelitis. J Exp Med 1988;167:1586-1596.
11. Oksenberg JR, Stuart S, Begovich AB, et al. Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature 1990;345:344- 346.
12. Wucherpfennig KW, Ota K, Endo N, et al. Shared human T cell receptor usage to immunodominant regions of myelin basic protein. Science 1990;248:1016-1019.
13. Oksenburg JR, Sherritt M, Begovich AB, et al. T cell receptor Va and Ca alleles associated with multiple sclerosis and myasthenia gravis. Proc Natl Acad Sci USA 1989;86:988-992.
14. Martell M, Marcadet A, Strominger J, et al. Alpha genes of the T-cell receptor: a possible implication in genetic susceptibility to multiple sclerosis. C R Acad Sci 1987;304:105-110.
15. Lynch SG, Rose JW, Petajan JH, et al. Discordance of the T cell receptor beta chain gene in familial multiple sclerosis. Ann Neurol 1991;30:402-410.
16. Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983;13:227-231.
17. Lynch SG, Rose JW, Smoker W, Petajan JH. MRI in familial multiple sclerosis. Neurology 1990;40:900-903.
18. Neitzel H. A routine method for the establishment of permanent growing lymphoblastoid cell lines. Hum Genet 1986;73:320-326.
19. Bell GI, Karan JH, Rutter WJ. Polymorphic DNA region adjacent to the 5’ end of the human insulin gene. Proc Natl Acad Sci USA 1981;78:5759-5763.
20. Maniatis T, Fritsch EF, Sambrook J. Molecular cloning: a laboratory manual, 1st ed. Cold Spring Harbor Laboratory, 1982:104-107.
21. Reed KC, Mann DA. Rapid transfer of DNA from agarose gels to nylon membranes. Nucleic Acids Res 1985;13:7207-7221.
22. Yanagi Y, Chan A, Chin B, Minden M, Mak T. Analysis of cDNA clones specific for human T cells and the a and p chains of the T-cell receptor heterodimer from a human cell line. Proc Natl Acad Sci USA 1985;82:3430-3434.
23. Feinberg AP, Vogelstein B. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 1982;132:6-13.
24. Rigaud G, Grange T, Pictet T. The use of NaOH as transfer solution of DNA onto nylon membranes decreases the hybridization efficiency. Nucleic Acids Res 1987;15:857.
25. Lathrop GM, Lalouel J-M, Julier C, Ott J. Multilocus linkage analysis in humans: detection of linkage and estimate of recombination. Am J Hum Genet 1985;37:482-498.
26. Nelson LM, Hamman RF, Thompson DS, et al. Higher than expected prevalence of multiple sclerosis in northern Colorado: dependence on methodologic issues. Neuroepidemiology 1986;5:17-28.
27. Mitchell AL, Bale AE, Mak T, McBride OW. Six RFLPs for human T cell receptor a (TCRA) on chromosome 14. Nucleic Acids Res 1989; 17:2876.
28. Fronek Z, Lentz D, Berliner N, et al. Systemic lupus erythematosus is not genetically linked to the beta chain of the T cell receptor. Arthritis Rheum 1986;29:1023-1025.
29. Wong DW, Bentwich Z, Martinez-Tarquino C, et al. Nonlinkage of the T cell receptor alpha, beta, and gamma genes to systemic lupus erythematosus in multiplex families. Arthritis Rheum 1988;31:1371-1376.
30. Hoover ML, Angelini G, Ball E, et al. HLA-DQ and T cell receptor genes in insulin dependent diabetes mellitus. Cold Spring Harb Symp Quant Biol 1986:803-810.
31. Ito M, Tanimoto M, Kamura H, et al. Association of HLA antigen and restriction fragment length polymorphisms of the T cell receptor beta chain gene with Graves’ disease and Hashimoto’s thyroiditis. J Clin Endocrinol Metab 1989; 69:100-104.
32. Ott J. Penetrance. In: Analysis of human genetic linkage. Baltimore: The Johns Hopkins University Press, 1985:132-146.