Differential Effects of Bryostatin 1 and Phorbol Ester on Human Breast Cancer Cell Lines

Cancer Research

Volumn 52, Issue 5, 1992, Pages 1278-1283

  John Kennedy, M ^a   Prestigiacomo, Laura J ^a   Tyler, Greg ^a   Stratford May, W ^a   Davidson, Nancy E ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRYOSTATIN 1; ISOENZYME; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL STRAIN MCF 7; CELL STRUCTURE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEMBRANE; MEMBRANE TRANSPORT; PRIORITY JOURNAL;

BREAST NEOPLASMS; CELL DIVISION; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; HUMAN; ISOENZYMES; LACTONES; PROTEIN KINASE C; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

EID: 0026602830     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Bachrach, L. K., Eggo, M. C., Mak, W. W., and Burrow, G. N. Phorbol esters stimulate growth and inhibit differentiation in cultured thyroid cells. Endocrinology, 116:1603-1609,198S.
2. Rossoft, P. M., Stein, L. F., and Cantley, L. C. Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na*/H* exchange. J. Biol. Chem., 259:7056-7060,1984.
3. Leach, K. L., James, M. L., and Blumberg, P. M. Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol. Proc. Natl. Acad. Sci. USA, 80:4208-4212,1983.
4. Castagna, M., Takai, Y., Kaibuci, K., Sano, K., Kikkawa, U., and Nishizuka, Y. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem., 257:7847-7851, 1982.
5. Kaibuchi, K., Sano, K., Hoshijima, M., Takai, Y., and Nishizuka, Y. Phosphatidylinositol turnover in platelet activation; calcium mobilization and protein phosphorylation. Cell Calcium, 3:323-335, 1982.
6. Rink, T. J., Sanchez, A., and Hallam, T. J. Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets. Nature (Lond.), 305:317-319,1983.
7. van de Werve, G., Proietto, J., and Jeanrenaud, B. Tumor-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding. Biochem. J., 225:523-527,1985.
8. Nishizuka, Y. Studies and prospectives of the protein kinase C family for cellular regulation. Cancer (Phila.), 63: 1892-1903,1989.
9. Berkow, R. L., and Kraft, A. S. Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor. Biochem. Biophys. Res. Commun., 131: 1109-1115,1985.
10. Dell'Aquila, M. L., Nguyen, H. T., Herald, C. L., Pettit, G. R., and Blumberg, P. M. Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells. Cancer Res., 47:6006-6009,1987.
11. Dell'Aquila, M. L., Herald, C. L., Pettit, G. R., and Blumberg, P. M. Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H IOTV2 cells. Cancer Res., 48:3702-3708, 1988.
12. Gschwendt, M., Ftirstenberger, G., Rose-John, S., Rogers, M., Pettit, G. R., Herald, C. L., and Marks, F. Bryostatin 1, an activator of protein kinase C., mimics as well as inhibits biological effects of the phorbol ester TPA in vivo and in vitro. Carcinogenesis (Lond.), 9:555-562,1988.
13. Kraft, A. S., Baker, V. V., and May, W. S. Bryostatin induces changes in protein kinase C location and activity without altering c-myc gene expression in human promyelocytic leukemia cells (HL-60). Oncogene, 1: 111-118, 1987.
14. O'Brian, C. A., Vogel, V. G., Singletaty, S. E., and Ward, N. E. Elevated levels of protein kinase C expression in human breast biopsies relative to normal tissue. Cancer Res., 49:3215-3217,1989.
15. Darbon, J-M., Valette, A., and Bayard, F. Phorbol esters inhibit the proliferation of MCF-7 cells: possible implications of protein kinase C. Biochem. Pharmacol., 35:2683-2686,1986.
16. Valette, A., Gas, N., Jozan, S., Roubinet, F., Dupont, M. A., and Bayard, F. Influence of 12-0-tetradecanoylphorbol-13-acetate on proliferation and maturation of human breast carcinoma cells (MCF-7): relationship to cell cycle events. Cancer Res., 47:1615-1620,1987.
17. Pettit, G. R., Day, J. F., Hartwell, J. L., and Wood, H. B. Antineoplastic components of marine animals. Nature (Lond.), 227:962-963, 1970.
18. May, W. S., Sharkis, S. J., Esa, A. H., Gebbia, V., Kraft, A. S., Pettit, G. R., and Sensenbrenner, L. L. Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells. Proc. Natl. Acad. Sci. USA, 84:8483-8487, 1987.
19. Hennings, H., Blumberg, P. M., Pettit, G. R., Herald, C. L., Shores, R., and Yuspa, S. H. Bryostatin 1, an activator of protein kinase C., inhibits tumor promotion by phorbol esters in SENCAR mouse skin. Carcinogenesis (Lond.), 8: 1343-1346, 1987.
20. Huang, K. P., Nakabayashi, H., and Huang, F. L. Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase. Proc. Natl. Acad. Cis ITCA 1QR7
21. Brandt, S. J., Niedel, J. E., Bell, R. M., and Yong, S. W., III. Distinct patterns of expression of different protein kinase C mRNAs in rat tissues. Cell, 49:57-63, 1987.
22. Hidaka, H., Tanaka, T., Onoda, K., Ito, Y., Tsurodome, M., and Yoshida, Y. Cell-type-specific expression of protein kinase C isozymes in the rabbit cerebellum. J. Biol. Chem., 263:4523-4526,1988.
23. Hocevar, B. A., and Fields, A. P. Selective translocation of ftrprotein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells. J. Biol. Chem., 266:28-33, 1991.
24. Nishizuka, V. The family of protein kinase C for signal transduction. JAMA, 262: 1826-1833,1989.
25. Kraft, A. S., Smith, J. B., and Berkow, R. L. Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60. Proc. Natl. Acad. Sci. USA, 83: 1334-1338,1986.
26. Warren, B. S., Kamano, Y., Pettit, G. R., and Blumberg, P. M. Mimicry of bryostatin 1 induced phosphorylation patterns in HL-60 cells by high phorbol ester concentrations. Cancer Res., 48:5984-5988, 1988.
27. Gopalakrishna, R., and Barsky, S. H. Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis. Proc. Natl. Acad. Sci. USA, E5:612-616, 1988.
28. Schwartz, G. K., Redwood, S. M., Ohnuma, T., Holland, J. F., Droller, M. J., and Liu, B. C-S. Inhibition of invasion of invasive human bladder carcinoma cells by protein kinase C inhibitor staurosporine. J. Natl. Cancer Inst., 82: 1753-1756,1990.