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Volumn 19, Issue 2, 1992, Pages 264-271

The sinus node inhibitor UL-FS 49 lacks significant inotropic effect

Author keywords

Hemodynamics; Inotropic state; Multiple regression modeling; Ventricular function

Indexed keywords

ZATEBRADINE;

EID: 0026602324     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/00005344-199202000-00015     Document Type: Article
Times cited : (18)

References (30)
  • 1
    • 0025237743 scopus 로고
    • On the mechanism of the "specific bradycardic action" of the verapamil derivative UL-FS 49
    • Doerr T, Trautwein W. On the mechanism of the "specific bradycardic action" of the verapamil derivative UL-FS 49. Arch Pharmacol 1990;341:331-40.
    • (1990) Arch Pharmacol , vol.341 , pp. 331-340
    • Doerr, T.1    Trautwein, W.2
  • 2
    • 0021175617 scopus 로고
    • Cardiovascular characterization of UL-FS 49, 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(3,4 dimethoxyphenyI)ethyl]methylimino] propyl]-2H-3-benzazepin-2-on hydrochloride, a new "specific bradycardic agent."
    • Kobinger W, Lillie C. Cardiovascular characterization of UL-FS 49, 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(3,4 dimethoxyphenyI)ethyl]methylimino] propyl]-2H-3-benzazepin-2-on hydrochloride, a new "specific bradycardic agent." Eur J Pharmacol 1984;104:9-18.
    • (1984) Eur J Pharmacol , vol.104 , pp. 9-18
    • Kobinger, W.1    Lillie, C.2
  • 3
    • 0022475465 scopus 로고
    • Investigations into the bradycardic effects of UL-FS 49 ( 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylimino] propyl]-2H-3-benzazepin-2-on-hydrochloride) in isolated guinea pig atria
    • Lillie C, Kobinger W. Investigations into the bradycardic effects of UL-FS 49 ( 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylimino] propyl]-2H-3-benzazepin-2-on-hydrochloride) in isolated guinea pig atria. J Cardiovasc Pharmcol 1986;8:791-7.
    • (1986) J Cardiovasc Pharmcol , vol.8 , pp. 791-797
    • Lillie, C.1    Kobinger, W.2
  • 5
    • 0023543598 scopus 로고
    • Role of heart rate reduction in the treatment of exercise-induced myocardial ischaemia
    • Guth BD, Heusch G, Seitekberger R, Matsuzaki M, Ross J. Role of heart rate reduction in the treatment of exercise-induced myocardial ischaemia. Eur Heart J 1987;8:61-8.
    • (1987) Eur Heart J , vol.8 , pp. 61-68
    • Guth, B.D.1    Heusch, G.2    Seitekberger, R.3    Matsuzaki, M.4    Ross, J.5
  • 6
    • 0022892538 scopus 로고
    • Can exercise-induced regional contractile dysfunction be prevented by selective bradycardic agents?
    • Krumpl G, Schneider W, Raberger G. Can exercise-induced regional contractile dysfunction be prevented by selective bradycardic agents? Naunyn Schmiedebergs Arch Pharmacol 1986;334:540-3.
    • (1986) Naunyn Schmiedebergs Arch Pharmacol , vol.334 , pp. 540-543
    • Krumpl, G.1    Schneider, W.2    Raberger, G.3
  • 7
    • 0023444617 scopus 로고
    • Specific bradycardic agents, a new therapeutic modality for anesthesiology: Hemodynamic effects of UL-FS 49 and propranolol in conscious and isoflurane-anesthetized dogs
    • Riley DC, Gross GJ, Kampine JP, Warltier DC. Specific bradycardic agents, a new therapeutic modality for anesthesiology: Hemodynamic effects of UL-FS 49 and propranolol in conscious and isoflurane-anesthetized dogs. Anesthesiology 1987;67:707-16.
    • (1987) Anesthesiology , vol.67 , pp. 707-716
    • Riley, D.C.1    Gross, G.J.2    Kampine, J.P.3    Warltier, D.C.4
  • 8
    • 0022001281 scopus 로고
    • Action of two new bradycardic agents, AQ-AH 208 and UL-FS 49, on ischemic myocardial perfusion and function
    • Dammgen JW, Lamping KA, Gross GJ. Action of two new bradycardic agents, AQ-AH 208 and UL-FS 49, on ischemic myocardial perfusion and function. J Cardiovasc Pharmcol 1985;7:71-9.
    • (1985) J Cardiovasc Pharmcol , vol.7 , pp. 71-79
    • Dammgen, J.W.1    Lamping, K.A.2    Gross, G.J.3
  • 9
    • 0023940161 scopus 로고
    • Comparison of the hemodynamic effects of the selective bradycardic agent UL-FS 49, with those of propranolol during treadmill exercise in dogs
    • Krumpl G, Winkler M, Schneider W, Raberger G. Comparison of the hemodynamic effects of the selective bradycardic agent UL-FS 49, with those of propranolol during treadmill exercise in dogs. Br J Pharmacol 1988;94:55-64.
    • (1988) Br J Pharmacol , vol.94 , pp. 55-64
    • Krumpl, G.1    Winkler, M.2    Schneider, W.3    Raberger, G.4
  • 10
    • 0023585074 scopus 로고
    • Effects of specific bradycardic agents on exercise-induced regional myocardial dysfunction in dogs
    • Raberger G, Krumpl G, Schneider W1 Mayer N. Effects of specific bradycardic agents on exercise-induced regional myocardial dysfunction in dogs. Eur Heart J 1987;8:53-9.
    • (1987) Eur Heart J , vol.8 , pp. 53-59
    • Raberger, G.1    Krumpl, G.2    Schneider W1 Mayer, N.3
  • 11
    • 0024419858 scopus 로고
    • Mechanisms of improved ischemic regional dysfunction by bradycardia, studies on UL-FS 49 in swine
    • Indolfi C, Guth BD, Miura T, Miyazaki S, Schulz R, Ross J Jr. Mechanisms of improved ischemic regional dysfunction by bradycardia, studies on UL-FS 49 in swine. Circulation 1989;80:983-93.
    • (1989) Circulation , vol.80 , pp. 983-993
    • Indolfi, C.1    Guth, B.D.2    Miura, T.3    Miyazaki, S.4    Schulz, R.5    Ross, J.6
  • 12
    • 0023156158 scopus 로고
    • Effects of the bradycardic agent UL-FS 49 on exercise-induced regional contractile dysfunction in dogs
    • Raberger G, Krumpl G, Mayer N, Schneider W. Effects of the bradycardic agent UL-FS 49 on exercise-induced regional contractile dysfunction in dogs. Int J Cardiol1987; 14: 343-54.
    • (1987) Int J Cardiol , vol.14 , pp. 343-354
    • Raberger, G.1    Krumpl, G.2    Mayer, N.3    Schneider, W.4
  • 13
    • 0025880090 scopus 로고
    • Cardiac cycle length modulates cardiovascular regulation that depends on previous beat contraction history
    • Slinker BK. Cardiac cycle length modulates cardiovascular regulation that depends on previous beat contraction history. Circ Res 1991;69:2-11.
    • (1991) Circ Res , vol.69 , pp. 2-11
    • Slinker, B.K.1
  • 14
    • 0024604588 scopus 로고
    • Beat-to-beat regulation of left ventricular function in the intact cardiovascular system
    • Slinker BK, Glantz SA. Beat-to-beat regulation of left ventricular function in the intact cardiovascular system. Am J Physiol 1989;256:R962-75.
    • (1989) Am J Physiol , vol.256 , pp. R962-R975
    • Slinker, B.K.1    Glantz, S.A.2
  • 15
    • 0021719407 scopus 로고
    • Continuous measurement of left ventricular volume in animal and humans by conductance catheter
    • Baan J, Van Der Veld ET, De Bruin HDG, et al. Continuous measurement of left ventricular volume in animal and humans by conductance catheter. Circulation 1984;70:812-23.
    • (1984) Circulation , vol.70 , pp. 812-823
    • Baan, J.1    Van Der Veld, E.T.2    De Bruin, H.D.G.3
  • 16
    • 0019555664 scopus 로고
    • Maximal negative dp/dt as an indicator of end of systole
    • Abel FR. Maximal negative dp/dt as an indicator of end of systole. Am J Physiol 1981;240:H676-9.
    • (1981) Am J Physiol , vol.240 , pp. H676-H679
    • Abel, F.R.1
  • 17
    • 0024429821 scopus 로고
    • Left ventricular volume measurement by conductance catheter in intact dogs: Parallel conductance volume depends on left ventricular size
    • Boltwood CM Jr, Appleyard RF, Glantz SA. Left ventricular volume measurement by conductance catheter in intact dogs: Parallel conductance volume depends on left ventricular size. Circulation 1989;80:1360-77.
    • (1989) Circulation , vol.80 , pp. 1360-1377
    • Boltwood, C.M.1    Appleyard, R.F.2    Glantz, S.A.3
  • 19
    • 0022363775 scopus 로고
    • Multiple regression for physiological data analysis; the problem of multicollinearity
    • Slinker BK, Glantz SA. Multiple regression for physiological data analysis; the problem of multicollinearity. Am J Physiol 1985;249:R1-12.
    • (1985) Am J Physiol , vol.249 , pp. R1-12
    • Slinker, B.K.1    Glantz, S.A.2
  • 21
    • 84935318018 scopus 로고
    • (ed). Berkeley: University of California Press
    • Dixon WJ (ed). BMDP Statistical Software Manual, Vol. 1. Berkeley: University of California Press,1988;147-9.
    • (1988) BMDP Statistical Software Manual , vol.1 , pp. 147-149
    • Dixon, W.J.1
  • 22
    • 0004155709 scopus 로고
    • Lexington, MA: DC Heath & Co.
    • Hsia TC. System identification. Lexington, MA: DC Heath & Co.,1977;77-81.
    • (1977) System identification , pp. 77-81
    • Hsia, T.C.1
  • 23
    • 84881172698 scopus 로고
    • Regression analysis and its application; a data-oriented approach
    • Gunst RF, Mason RL. Regression analysis and its application; a data-oriented approach. New York: Dekker,1980; 234-6.
    • (1980) New York: Dekker , pp. 234-236
    • Gunst, R.F.1    Mason, R.L.2
  • 24
    • 33646899705 scopus 로고
    • Primer of applied regression and analysis of variance
    • Glantz SA, Slinker BK. Primer of applied regression and analysis of variance. New York: McGraw-Hill,1990;239-69.
    • (1990) New York: McGraw-Hill , pp. 239-269
    • Glantz, S.A.1    Slinker, B.K.2
  • 26
    • 0015740989 scopus 로고
    • Influence of previous mechanical events on the contractility of isolated cat papillary muscle
    • Jewell BR, Rovell JM. Influence of previous mechanical events on the contractility of isolated cat papillary muscle. J Physiol (Lond) 1973;235:715-40.
    • (1973) J Physiol (Lond) , vol.235 , pp. 715-740
    • Jewell, B.R.1    Rovell, J.M.2
  • 27
    • 0014987355 scopus 로고
    • Feedback interaction of mechanical and electrical events in isolated mammalian ventricular myocardium (cat papillary muscle)
    • Kaufman RL, Lab MJ, Hennekes R, Krause H. Feedback interaction of mechanical and electrical events in isolated mammalian ventricular myocardium (cat papillary muscle). Pflügers Arch 1971;324:100-23.
    • (1971) Pflügers Arch , vol.324 , pp. 100-123
    • Kaufman, R.L.1    Lab, M.J.2    Hennekes, R.3    Krause, H.4
  • 28
    • 0019942851 scopus 로고
    • Analysis of mechanical altemans in rabbit papillary muscle
    • Wohlfart B. Analysis of mechanical altemans in rabbit papillary muscle. Acta Physiol Scand 1982;115:405-14.
    • (1982) Acta Physiol Scand , vol.115 , pp. 405-414
    • Wohlfart, B.1
  • 29
    • 0014497705 scopus 로고
    • Effects of altered loading on contractile events in isolated cat papillary muscle
    • Parmley WW, Brutsaert DL, Sonnenblick EH. Effects of altered loading on contractile events in isolated cat papillary muscle. Circ Res 1969;24:521-32.
    • (1969) Circ Res , vol.24 , pp. 521-532
    • Parmley, W.W.1    Brutsaert, D.L.2    Sonnenblick, E.H.3
  • 30
    • 0018016289 scopus 로고
    • Transient force responses in blood-perfused papillary muscle after step changes in load
    • Suga H, Sagawa K. Transient force responses in blood-perfused papillary muscle after step changes in load. Am J Physiol 1978;235:H267-75.
    • (1978) Am J Physiol , vol.235 , pp. H267-H275
    • Suga, H.1    Sagawa, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.