Increased Sensitivity of Human Keratinocytes Immortalized by Human Papillomavirus Type 16 DNA to Growth Control by Retinoids

Cancer Research

Volumn 52, Issue 1, 1992, Pages 187-193

  Creek, Kim E ^b,b   Ronald Jenkins, G ^b   Hodam, John R ^b  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE; RETINOIC ACID; RETINOL;

ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; KERATINOCYTE; MALE; PAPILLOMA VIRUS; PREPUCE; PRIORITY JOURNAL;

BETA CAROTENE; CAROTENOIDS; CELL DIVISION; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; HUMAN; KERATIN; KERATINOCYTES; PAPILLOMAVIRUS; RNA, VIRAL; SUPPORT, NON-U.S. GOV'T; TRETINOIN; VITAMIN A;

EID: 0026597837     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (76)

1. zur Hausen, H. Papillomaviruses in human cancers. Mol. Carcinogen., 1: 147-150, 1988.
2. zur Hausen, H. Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers. Cancer Res., 49: 4677-4681, 1989.
3. Pirisi, L., Yasumoto, S., Feller, M., Doniger, J., and DiPaolo, J. A. Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J. Virol., 61: 1061-1066, 1987.
4. Pirisi, L., Creek, K. E., Doniger, J., and DiPaolo, J. A. Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis (Lond.), 9: 1573-1579, 1988.
5. Durst, M., Dzarlieva-Petrusevska, R. T., Boukamp, P., Fusenig, N. E., and Gissmann, L. Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA. Oncogene, 1: 251-256, 1987.
6. Woodworth, C. D., Doniger, J., and DiPaolo, J. A. Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma. J. Virol., 63:159-164, 1989.
7. Kaur, P., and McDougall, J. K. Characterization of primary human keratinocytes transformed by human papillomavirus type 18. J. Virol., 62: 1917-1924, 1988.
8. Woodworth, C. D., Bowden, P. E., Doniger, J., Pirisi, L., Barnes, W., Lancaster, W. D., and DiPaolo, J. A. Characterization of normal human exocervical epithelial cells immortalized in vitro by papillomavirus types 16 and 18 DNA. Cancer Res., 48:4620-4628, 1988.
9. Baker, C. C., Phelps, W. C., Lindgren, V., Braun, M. J., Gonda, M. A., and Howley, P. M. Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J. Virol., 61: 962-971, 1987.
10. Schwarz, E., Freese, U. K., Gissmann, L., Mayer, W., Roggenbuck, B., Stremlau, A., and zur Hausen, H. Structure and description of human papillomavirus sequences in cervical carcinoma cells. Nature (Lond.), 314: 111-114, 1985.
11. Yee, C., Krishnan-Hewlett, L., Baker, C. C., Schlegel, R., and Howley, P. M. Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. Am. J. Pathol., 119: 361-366,1985.
12. Crook, T., Morgenstrem, J. P., Crawford, L., and Banks, L. Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras. EMBO J., 8:513-519, 1989.
13. Hawley-Nelson, P., Vousden, K. H., Hubbert, N. L., Lowy, D. R., and Schiller, J. T. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J., 8:3905-3910,1989.
14. Hudson, J. B., Bedell, M. A., McCance, D. J., and Laimins, L. A. Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18. J. Virol., 64:519-526, 1990.
15. Barbosa, M. S., and Schlegel, R. The E6 and E7 genes of HPV-18 are sufficient for inducing two-stage in vitro transformation of human keratinocytes. Oncogene, 4: 1529-1532, 1989.
16. Phelps, W. C., Yee, C. L., Munger, K., and Howley, P. M. The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus El A. Cell, 53:539-547,1988.
17. Dyson, N., Howley, P. M., Munger, K., and Harlow, E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science (Washington DC), 243:934-937, 1989.
18. Munger, K., Werness, B. A., Dyson, N., Phelps, W. C., Harlow, E., and Howley, P. M. Complex formation of human papillomavirus El proteins with the retinoblastoma tumor suppressor gene product. EMBO J., 8:4099-4105, 1989.
19. Gage, J. R., Meyers, C., and Wettstein, F. O. The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties. J. Virol., 64: 723-730, 1990.
20. Werness, B. A., Levine, A. J., and Howley, P. M. Association of human papillomavims types 16 and 18 E6 proteins with p53. Science (Washington DC), 248: 76-79, 1990.
21. Elias, P. M., and Williams, M. L. Retinoids, cancer, and the skin. Arch. Dermatol., 117: 160-180, 1981.
22. Sporn, M. B., and Roberts, A. B. Role of retinoids in differentiation and carcinogenesis. Cancer Res., 43: 3034-3040,1983.
23. Wolf, G. Multiple functions of vitamin A. Physiol. Rev., 64:873-937,1984.
24. Roberts, A. B., and Sporn, M. B. Cellular Biology and biochemistry of the retinoids. In: M. B. Sporn, A. B. Roberts, and D. S. Goodman (eds.), The Retinoids, Vol. 2, pp. 209-287. New York: Academic Press, 1984.
25. Moon, R. C., and Itri, L. M. Retinoids and cancer. In: M. B. Sporn, A. B. Roberts, and D. S. Goodman (eds.). The Retinoids, Vol. 2, pp. 327-371. New York: Academic Press, 1984.
26. Bertram, J. S., Kolonel, L. N., and Meyskens, F. L. Rationale and strategies for chemoprevention of cancer in humans. Cancer Res., 47: 3012-3031, 1987.
27. Peck, G. L. Chemoprevention of cancer with retinoids. Gynecol. Oncol., 72(Suppl.);s331-s340, 1981.
28. Hill, D. L., and Gmbbs, C. L. Retinoids as chemopreventive and anticancer agents in intact animals (review). Anticancer Res., 2:111-124,1982.
29. Lippman, S. M., Kessler, J. F., and Meyskens, F. L. Retinoids as preventive and therapeutic anticancer agents (part I). Cancer Treat. Rep., 71:391-405, 1987.
30. Verma, A. K., Shapas, B. G., Rice, H. M., and Boutwell, R. K. Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal omithine decarboxylase activity and of skin tumor promotion. Cancer Res., 59:419-425, 1979.
31. Ito, Y. Effect of an aromatic retinoic acid analog (RO 10-9359) on growth of vims-induced papilloma (Shope) and related neoplasia of rabbits. Eur. J. Cancer, 17:35-42, 1981.
32. McMichael, H. Inhibition of growth of Shope rabbit papilloma by hypervi-taminosis A. Cancer Res., 25:947-955, 1965.
33. Bjelke, E. Dietary vitamin A and human lung cancer. Int. J. Cancer, 15:561-565, 1975.
34. Graham, S. Results of case-control studies of diet and cancer in Buffalo, New York. Cancer Res., 43(Suppl.); 2409s-2413s, 1983.
35. Kark, J. D., Smith, A. H., Switzer, B. R., and Hames, C. G. Semm vitamin A (retinol) and cancer incidence in Evans County, Georgia. J. Natl. Cancer Inst., 66: γ-16,1981.
36. Mettlin, C., Graham, S., and Swanson, M. Vitamin A and lung cancer. J. Natl. Cancer Inst., 62: 1435-1438,1979.
37. Shekelle, R. B., Lepper, M., Liu, S., Maliza, C., Raynor, W. J., Rossof, A. H., Paul, O., Shryock, A. M., and Stamler, J. Dietary vitamin A and risk of cancer in the Westem Electric study. Lancet, 2:1185-1190,1981.
38. Wald, N., Idle, M., Boreham, J., and Bailey, A. Low semm-vitamin-A and subsequent risk of cancer. Lancet, 2:813-815, 1980.
39. Bemstein, A., and Harris, B. The relationship of dietary and semm vitamin A to the occurrence or cervical intraepithelial neoplasia in sexually active women. Am. J. Obstet. Gynecol., 148:309-312, 1984.
40. Hirayama, T. Diet and cancer. Nutr. Cancer, 1:67-81,1979.
41. Marshall, J. R., Graham, S., Byers, T., Swanson, M., and Brasure, J. Diet and smoking in the epidemiology of cancer of the cervix. J. Natl. Cancer Inst., 70:847-851,1983.
42. Romney, S. L., Palan, P. R., Duttagupta, C., Wassertheil-Smoller, S., Wylie, J., Miller, G., Slagle, N. S., and Lucido, D. Retinoids and the prevention of cervical dysplasias. Am. J. Obstet. Gynecol., 141:890-894, 1981.
43. Graham, V., Surwit, E. S., Weiner, S., and Meyskens, F. L. Phase II trial of l3-all-/ran5-retinoic acid for cervical intraepithelial neoplasia delivered via a collagen sponge and cervical cap. West. J. Med., 145:192-195, 1986.
44. Meyskens, F. L., Graham, V., Chvapil, M., Dorr, R. T., Alberts, D. S., and Surwit, E. A. A phase I trial of -all-rra/i5-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia. J. Natl. Cancer Inst., 71:921-925, 1983.
45. Meyskens, F. L. and Sunvit, E. S. Clinical experience with topical tretinoin in the treatment of cervical dysplasia. J. Am. Acad. Dermatol., 15:826-829, 1986.
46. Peng, Y. M., Alberts, D. S., Graham, V., Sunvit, E. A., Weiner, S., and Meyskens, F. L. Cervical tissue uptake of all-rra/i5-retinoic acid delivered via a collagen sponge-cervical cap delivery device in patients with cervical dysplasia. Invest. New Drugs, 4: 245-249, 1986.
47. Surwit, E. A., Graham, V., Droegemueller, W., Alberts, D., Chvapil, M., Dorr, R. T., Davis, J. R., and Meyskens, F. L. Evaluation of topically applied trans-retmoic acid in the treatment of cervical intraepithelial lesions. Am. J. Obstet. Gynecol., 143:821-823, 1982.
48. Weiner, S. A., Surwit, E. A., Graham, V. E., and Meyskens, F. L. A phase I trial of topically applied fra/i5-retinoic acid in cervical dysplasia-clinical efficacy. Invest. New Drugs, 4: 241-244, 1986.
49. Bowden, P. E., Quinlan, R. A., Breitkreutz, D., and Fusenig, N. E. Proteolytic modification of acidic and basic keratins during terminal differentiation of mouse and human epidermis. Eur. J. Biochem., 142:29-36, 1984.
50. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227:680-685, 1970.
51. Creek, K. E., Silverman-Jones, C. S., and De Luca, L. M. Comparison of the uptake and metabolism of retinol delivered to primary mouse keratinocytes either free or bound to rat serum retinol-binding protein. J. Invest. Dermatol., 92:283-289, 1989.
52. Yasumoto, S., Doniger, J., and DiPaolo, J. A. Differential early viral gene expression in two stages of human papillomavirus type 16 DNA-induced malignant transformation. Mol. Cell. Biol., 7: 2165-2172,1987.
53. Fuchs, E., and Green, H. Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell, 25:617-625, 1981.
54. Gilfix, B. M., and Eckert, R. L. Coordinate control by vitamin A of keratin gene expression in human keratinocytes. J. Biol. Chem., 260:14026-14029, 1985.
55. Eckert, R. L., and Green, H. Cloning of cDNAs specifying vitamin A-responsive human keratins. Proc. Natl. Acad. Sci. USA, 81: 4321-4325, 1984.
56. Moll, R., Franke, W. W., Schiller, D. L., Geiger, B., and Krepler, R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell, 31: 11-24, 1982.
57. Petkovich, M., Brand, N. J. Krust, A., and Chambon, P. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature (Lond.), 330:444-450,1987.
58. Giguere, V., Ong, E. S., Segui, P., and Evans, R. M. Identification of a receptor for the morphogen retinoic acid. Nature (Lond.), 330: 624-629, 1987.
59. Evans, R. M. The steroid and thyroid hormone receptor superfamily. Science (Washington DC), 240:889-895, 1988.
60. Brand, N., Petkovich, M., Krust, A., Chambon, P., de The, H., Marchio, A., Tiollais, P., and Dejean, A. Identification of a second human retinoic acid receptor. Nature (Lond.), 332:850-853, 1988.
61. Benbrook, D., Lemhardt, E., and Pfahl, M. A new retinoic acid receptor identified from a hepatocellular carcinoma. Nature (Lond.), 333: 669-672, 1988.
62. Krust, A., Kastner, P., Petkovich, M., Zelent, A., and Chambon, P. A third human retinoic acid receptor, hRAR-gamma. Proc. Natl. Acad. Sci. USA, 5310-5314, 1989.
63. Zelent, A., Krust, A., Petkovich, M., Kastner, P., and Chambon, P. Cloning of murine or and retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature (Lond.), 339:714-717,1989.
64. Umesono, K., Giguere, V., Glass, C. K., Rosenfeld, M. G., and Evans, R. M. Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Nature (Lond.), 336:262-265,1988.
65. Gloss, B., Bernhard, H. U., Seedorf, K., and Klock, G. A. A DNA segment of the upstream regulatory region of the human papillomavirus-16 exhibits E2 protein-independent enhancer activity in a glucocorticoid hormone-regulated and cell type-specific fashion. EMBO J., 6:3735-3743,1987.
66. Chong, T., Chan, W. K., and Bernard, H. U. Transcriptional activation of human papillomavirus 16 by nuclear factor I., API, steroid receptors and a possibly novel transcription factor, PVF: a model for the composition of genital papillomavirus enhancers. Nucleic Acids Res., 18:465-470,1990.
67. Pater, M. M., Hughes, G. A., Hyslop, D. E., Nakshatri, H., and Pater, A. Glucocorticoid-dependent oncogenic transformation by type 16 but not type 11 human papilloma virus DNA. Nature (Lond.), 335:832-835,1988.
68. Batova, A., Pirisi, L., and Creek, K. E. Retinoic acid induces the secretion of latent transforming growth factor-beta in normal and human papillomavirus type 16 immortalized human keratinocytes. Proc. Am. Assoc. Cancer Res., 31:56, 1990.
69. Glick, A. B., Handers, K. C., Danielpour, D., Yuspa, S. H., and Sporn, M. B. Retinoic acid induces transforming growth factor-β2 in cultured keratin-ocytes and mouse epidermis. Cell Regul., 1:87-97,1989.
70. Shipley, G. D., Pittelkow, M. R., Wille, J. J., Scott, R. E., and Moses, H. L. Reversible inhibition of normal human prokeratinocyte proliferation by type β transforming growth factor-growth inhibitor in serum-free medium. Cancer Res., 46: 2068-2071,1986.
71. Coffey, R. J., Sipes, N. J., Bascom, C. C., Graves-Deal, R., Pennington, C. Y., Weissman, B. E., and Moses, H. L. Growth modulation of mouse keratinocytes by transforming growth factors. Cancer Res., 48: 1596-1602, 1988.
72. Reiss, M., and Sartorelli, A. C. Regulation of growth and differentiation of human keratinocytes by type β transforming growth factor and epidermal growth factor. Cancer Res., 47:6705-6709, 1987.
73. Dennis, P. A., and Rifkin, D. B. Cellular activation of latent transforming growth factor β requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc. Natl. Acad. Sci. USA, 88: 580-584,1991.
74. Woodworth, C. D., Notario, V., and DiPaolo, J. A. Transforming growth factors beta 1 and 2 transcriptionally regulate human papillomavirus (HPV) type 16 early gene expression in HPV-immortalized human genital epithelial cells. J. Virol., 64:4767-4775,1990.
75. Pietenpol, J. A., Stein, R. W., Moran, E., Yaciuk, P., Schlegel, R., Lyons, R. M., Pittelkow, M. R., Munger, K., Howley, P. M., and Moses, H. L. TGF-jSl inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell, 61: 777-785, 1990.
76. Agarwal, C., Rorke, E. A., Irwin, J. C., and Eckert, R. L. Immortalization by human papillomavirus type 16 alters retinoid regulation of human ecto-cervical epithelial cell differentiation. Cancer Res., 51:3982-3989,1991.