A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation

New England Journal of Medicine

Volumn 326, Issue 13, 1992, Pages 845-851

  Goodman, Jesse L ^a   Weisdorf, Daniel ^a   Winston, Drew J ^b   ho, Winston G ^b   Greenfield, Ronald A ^c   Chandrasekar, Pranatharthi H ^d   Fox, Barry ^e   Kaizer, Herbert ^f   Shadduck, Richard K ^g   Shea, Thomas C ^h   Stiff, Patrick ⁱ   Friedman, David J ^j   Powderly, William G ^k   Silber, Jeffrey L ^l   Horowitz, Harold ^m   Lichtin, Alan ⁿ   Wolff, Steven N ^o   Mangan, Kenneth F ^p   Silver, Samuel M ^q   Gilbert, Gene ^r   Buell, Donald ^r   more..

^a UNIV OF MINNESOTA HOSP AND CLINIC   (United States)

^b UCLA MEDICAL CENTER   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^d WAYNE STATE UNIVERSITY   (United States)

^e THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^f RUSH UNIVERSITY MEDICAL CENTER   (United States)

^g UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^h UCSD MEDICAL CENTER   (United States)

ⁱ LOYOLA UNIVERSITY CHICAGO   (United States)

^j UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^k UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^l HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^m NEW YORK MEDICAL COLLEGE   (United States)

ⁿ LERNER RESEARCH INSTITUTE   (United States)

^o VANDERBILT UNIVERSITY   (United States)

^p TEMPLE UNIVERSITY HEALTH SYSTEM   (United States)

^q UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^r PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; FLUCONAZOLE;

ARTICLE; ASPERGILLUS; BONE MARROW TRANSPLANTATION; CANDIDA; CONTROLLED STUDY; EOSINOPHILIA; FEMALE; HUMAN; INCIDENCE; INTRAVENOUS DRUG ADMINISTRATION; LIVER DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MUCORALES; MYCOSIS; NAUSEA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROPHYLAXIS; RASH; SIDE EFFECT; TORULOPSIS GLABRATA;

EID: 0026597735     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199203263261301     Document Type: Article

References (25)

1. O#x0027;Reilly R.J. Allogenic bone marrow transplantation: current status and future directions. Blood 1983; 5:941-964
2. Clift R.A. Candidiasis in the transplant patient. Am J Med 1984; 77:34-38
3. Saag M.S., Dismukes W.E. Azole antifungal agents: emphasis on new triazoles. Antimicrob Agents Chemother 1988; 32:1-8.
4. Meunier F., Aoun M., Gerard M. Therapy for oropharyngeal candidiasis in the immunocompromised host: a randomized double-blind study of fluconazole vs. ketoconazole. Rev Infect Dis 1990; 12:Suppl 3:S364-S368.
5. Conti D.J., Tolkoff-Rubin N.E., Baker G.P. Jr., et al. Successful treatment of invasive fungal infection with fluconazole in organ transplant recipients. Transplantation 1989; 48:692-695
6. Sugar A.M., Saundcrs C. Oral fluconazole as suppressive therapy of disseminated cryptococcosis in patients with acquired immunodeficiency syndrome. Am J Med 1988; 85:481-489
7. Walsh T.J., Lee J., Aoki S., et al. Experimental basis for use of fluconazole for preventive or early treatment of disseminated candidiasis in granulocytopenic hosts. Rev Infect Dis 1990; 12:Suppl 3:S307-S317.
8. Patterson T.F., Miniter P., Andriole V.T. Efficacy of fluconazole in experimental invasive aspergillosis. Rev Infect Dis 1990; 12:Suppl 3:S281-S285.
9. Lee E.P. Statistical methods for survival analysis. Belmont, Calif.: Lifetime Learning Publications, 1980.
10. Breslow N.E., Day N.E. Statistical methods in cancer research. Vol. 1. The analysis of case–control studies. Lyon, France; International Agency for Research on Cancer. 1980. (IARC scientific publications no. 32.)
11. Tollemar J., Ringden O., Bostrom L., Nilsson B., Sundberg B. Variables predicting deep fungal infections in bone marrow transplant recipients. Bone Marrow Transplant 1989:4:635-641
12. Verfaillie C., Weisdorf D., Haake R., Hostettcr M., Ramsay N., McGlave P. Candida infections in bone marrow transplant recipients. Bone Marrow Transplant 1991; 8:177-184
13. Wingard J.R., Dick J.D., Merz W.G., Sandford G.R., Saral R., Burns W.H. Differences in virulence of clinical isolates of Candida tropicalis and Candida albicans in mice. Infect Immun 1982; 37:833-836
14. Brammer K.W. Management of fungal infection in neutropenic patients with fluconazole. Hamatol Bluttransfus 1990; 33:546-550
15. Samonis G., Rolston K., Karl C., Miller P., Bodey G.P. Prophylaxis of oropharyngeal candidiasis with fluconazole. Rev Infect Dis 1990; 12:Suppl 3:S369-S373.
16. Shepp D.H., Klosterman A., Siegel M.S., Meyers J.D. Comparative trial of ketoconazole and nystatin for prevention of fungal infection in neutropenic patients treated in a protective environment. J Infect Dis 1985; 152:1257-1263
17. Wingard J.R., Vaughan W.P., Braine H.G., Merz W.G., Saral R. Prevention of fungal sepsis in patients with prolonged neutropenia: a randomized, double-blind, placebo-controlled trial of intravenous miconazole. Am J Med 1987; 83:1103-1110
18. Fainstein V., Bodey G.P. Cardiorespiratory toxicity due to miconazole. Ann Intern Med 1980; 93:432-433
19. Lewis J.H., Zimmerman H.J., Benson G.D., Ishak K.G. Hepatic injury associated with ketoconazole therapy: analysis of 33 cases. Gastroenterology 1984; 86:503-513
20. Bearman S.I., Appclbaum R.F., Buckncr C.D., et al. Regimen-related toxicity in patients undergoing bone marrow transplantation. J Clin Oncol 1988; 6: 1562-8.
21. Galgiani J.N. Antifungal susceptibility tests. Antimicrob Agents Chemother 1987; 31:1867-1870
22. Mcllroy M.A. Failure of fluconazole to suppress fungemia in a patient with fever, neutropenia, and typhlitis. J Infect Dis 1991; 163:420-421
23. Wingard J.R., Merz W.G., Rinaldi M.G., Johnson T.R., Karp J.E., Saral R. Increase in Candida krusei infection among patients with bone marrow transplantation and neutropenia treated prophylactically with fluconazole. N Engl J Med 1991; 325:1274-1277
24. Pizzo P.A., Robichaud K.J., Gill F.A., Witebsky F.G. Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia. Am J Med 1982; 72:101-111
25. EORTC International Antimicrobial Therapy Cooperative Group. Empiric antifungal therapy in febrile granulocytopenic patients. Am J Med 1989; 86: 668-72.