Cellular studies on antigen presentation by class II MHC molecules

Current Opinion in Immunology

Volumn 4, Issue 1, 1992, Pages 63-69

  Unanue, Emil R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEINASE;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; CYTOSOL; ENDOPLASMIC RETICULUM; LYSOSOME; MAJOR HISTOCOMPATIBILITY COMPLEX; PH; PROTEIN DENATURATION; REVIEW;

ANIMAL; ANTIGEN-PRESENTING CELLS; ANTIGENS; CELL COMPARTMENTATION; ENDOCYTOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HYDROGEN-ION CONCENTRATION; LYSOSOMES; MICE; ORGANELLES; PEPTIDE FRAGMENTS; PROTEIN BINDING;

EID: 0026591609     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/0952-7915(92)90127-Z     Document Type: Article

References (59)

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3. + T Cells Requires Secretion of Hemolysin and Intracellular Bacterial Growth
4. A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma
5. Human T Cell Response to the Surface Antigen of Hepatitis B Virus (HBsAg). Endosomal and Nonendosomal Processing Pathways are Accessible to Both Endogenous and Exogenous Antigen
6. HLA Class II-restricted Presentation of Cytoplasmic Measles Virus Antigen to Cytotoxic T Cells
7. Class II MHC Molecules Can Use the Endogenous Pathway of Antigen Presentation
8. An Endogenous Processing Pathway in Vaccinia Virus-infected Cells for Presentation of Cytoplasmic Antigens to Class II-restricted T Cells
9. Class II-MHC Restricted T Cell Determinants Processed From Either Endosomes or the Cytosol with Similar Requirements for Host Protein Transport but Different Kinetics of Production
10. MHC Class-II-restricted Presentation of Intracellular Antigen
11. B Lymphoma Cells Process and Present Their Endogenous Immunoglobulin to Major Histocompatibility Complex-restricted T Cells
12. Immunoglobulin-specific T-B Cell Interaction. II. T Cell Clones Recognize the Processed Form of B Cells' own Surface Immunoglobulin in the Context of the Major Histocompatibility Complex Class II Molecule
13. Presentation of IgG2a Antigens to Class II-restricted T Cells by Stably Transfected B Lymphoma Cells
14. Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme.
15. Cytosolic Targeting of Hen Egg Lysozyme Gives Rise to a Short-lived Protein Presented by Class-I but not Class-II Major Histocompatibility Complex Molecules
16. Processing of an Endogenous Protein can Generate MHC Class-II Restricted T Cell Determinants Distinct From Those Derived from Exogenous Antigen
17. The Regulatory Role of Macrophages in Antigenic Stimulation. Part Two: Symbiotic Relationship Between Lymphocytes and Macrophages
18. Liposome-encapsulating Antigens are Processed in Lysosomes, Recycled and Presented to T Cells
19. Liposome-encapsulated Antigen Engender Lysosomal Processing for Class II MHC Presentation and Cytosolic Processing for Class I Presentation
20. Differential Requirements for Antigen Processing by Macrophages for Lysozyme-specific T Cell Hybridoma
21. alpha Chain Does not Require Processing
22. k Histocompatibility Molecule Photoaffinity Labeled by an Immunogenic Lysozyme Peptide
23. Reduction of Disulphide Bonds in Lysosomes is a Key Step in Antigen Processing
24. Reduction of Disulphide Bonds During Antigen Processing: Evidence from a Thiol-dependent Insulin Determinant
25. Immunoliposomes with Different Acid Sensitivities as Probes for the Cellular Endocytic Pathway
26. pH Sensitive Liposomes: Acid-induced Fusion
27. Cellular and Subcellular Distribution of PBP72/74, a Peptide Binding Protein that Plays a Role in Antigen Processing
28. A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family
29. Co-localization of Molecules Involved in Antigen Processing and Presentation in an Early Endocytic Compartment
30. Functional and Ultrastructural Evidence for Intracellular Formation of Major Histocompatibility Complex Class II-Peptide Complexes During Antigen Processing
31. Segregation of MHC Class-II Molecules from MHC Class-I Molecules in the Golgi Complex for Transport to Lysosomal Compartments
32. The Biosynthetic Pathway of MHC Class-II but not Class-I Molecules Intersects the Endocytic Mute
33. Intracellular class II HLA antigens are accessible to transferrin-neuraminidase conjugates internalized by receptor-mediated endocytosis.
34. Antigen Processing and Intracellular Ia: Possible Roles of Endocytosis and Protein Synthesis in Ia Function
35. Mouse B Lymphocyte Specific Endocytosis and Recycling of MHC Class II Molecules
36. Endocytosis and Recycling of MHC-encoded Class II Molecules by Mouse B Lymphocytes
37. Class II MHC Molecules are Spontaneously Internalized in Acidic Endosomes by Activated B Cells
38. Cell Surface MHC Glycoproteins Cycle Through Primaquine Sensitive Intracellular Compartments
39. Turnover of Ia-peptide Complexes Facilitated in Viable Antigen-presenting Cells: Biosynthetic Turnover of Ia vs Peptide Exchange
40. Competition for Antigen Presentation in Living Cells Involves Exchange of Peptides Bound by Class II MHC Molecules
41. Processed Antigen Binds to Newly Synthesized MHC Class II Molecules in Antigen-specific B Lymphocytes
42. Regulation of Antigen Presentation by Acid pH
43. Enhanced Binding of Peptide Antigen to Purified Class II Major Histocompatibility Glycoproteins at Acidic pH
44. Effects of pH and Polysaccharides on Peptide Binding to Class II Major Histocompatibility Complex Molecules
45. Expression of a Class II Major Histocompatibility Complex (MHC) Heterodimer in a Lipid-linked Form with Enhanced Peptide/Soluble MHC Complex Formation at Low pH
46. Identification of Proteases that Process Distinct Epitopes on the Same Protein
47. A Group-selective Inhibitor of Lysosomal Proteinases Selectively Inhibits Both Proteolytic Degradation and Presentation of the Antigen Dinitrophenyl-poly-1-lysine by Guinea Pig Accessory Cells
48. Selective Inhibition of Antigen Presentation to Cloned T Cells by Protease Inhibitors
49. Different Roles for Thiol and Aspartyl Proteases in Antigen Presentation of Ovalbumin
50. The Generation of Immunogenic Peptides can be Selectively Increased or Decreased by Proteolytic Enzyme Inhibitors
51. Two Genetically Identical Antigen-presenting Cell Clones Display Heterogeneity in Antigen Processing
52. Characterization of Naturally Processed Antigen Bound to Major Histocompatibility Complex Class II Molecules
53. Sequence Analysis of Peptides Bound to MHC Class II Molecules
54. MHC Class II Structure, Occupancy and Surface Expression Determined by Post-endoplasmic Reticulum Antigen Binding
55. A Role for Peptide in Determining MHC Class II Structure
56. Refolding and Reassembly of Separate Alpha and Beta Chains of Class II Molecules of the Major Histocompatibility Complex Leads to Increased Peptide-binding Capacity
57. Mutation Affecting Antigen Processing Impair Class II Restricted Allorecognition
58. Defective Processing and Presentation of Exogenous Antigens in Mutants with Normal HLA Class II Genes