Capsaicin: Actions on C fibre aff erents that may be involved in itch

Skin Pharmacology and Physiology

Volumn 5, Issue 1, 1992, Pages 9-13

  Lynn, Bruce ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Capsaicin Itch; Nociceptor C fibre

Indexed keywords

CAPSAICIN; HISTAMINE;

ANIMAL EXPERIMENT; INTRADERMAL DRUG ADMINISTRATION; NERVE FIBER C; NONHUMAN; PRURITUS; RAT; REVIEW;

ANIMAL; CAPSAICIN; NERVE FIBERS; NEURONS, AFFERENT; PRURITUS; RATS; SKIN; SUPPORT, NON-U.S. GOV'T;

EID: 0026587911     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000211010     Document Type: Article

References (25)

1. Lynn B: Capsaicin: Actions on nociceptive C-fibres and therapeutic potential. Pain 1990;41:61-69.
2. Toth-Kasa I. Jancso G. Bognar A. Husz S. Obal F. Capsaicin prevents histamine-induced itching. Int J Clin Pharmacol Res 1986:6:163-169.
3. Cappugi P. Lotti T. Tsampau D. Danesi A. Zippi P. Bonan P. Pan-conizi E: Capsaicin treatment of different dermatological affections with itching. Skin Pharmacol 1989: 2:230.
4. Wallengren J: Treatment of notalgia paresthetica with capsaicin (Zos-trix®). Skin Pharmacol 1989:2:229-230.
5. Renins P: Responses of single nerve fibres to capsaicin applied to the skin. Neurosci Lett 1982:29:83-88.
6. Szolcsanyi J. Anton F. Reeh PW. Handworker HO: Selective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin. Brain Res 1988:446:262-268.
7. Foster RW. Ramage AG: The action of some chemical irritants on somatosensory' receptors of the cat. Neuropharmacology 1981:20:191-198.
8. Torebjork E. Lundberg L. LaMotte R: Neural mechanisms for capsai-cin-induced hyperalgesia. Pain 1990:85:s114
9. Lynn B. Ye W: Desensitization of C-fibrcs of the polymodal nociceptor type (C-PMNs) by intradermal injection of capsaicinoids (abstract). Proc 31st Int Congr Physiol Sci 1989. p 2496.
10. Lynn B: Neurogenic Inflammation. Skin Pharmacol 1988;1:217-224.
11. Baranowski R. Lynn B. Pini A: The effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species. Br J Pharmacol 1986;89:267-276.
12. Pini A. Baranowski R. Lynn B: Long-term reduction in the number of C-fibrc nociceptors following capsaicin treatment of a cutaneous nerve in adult rats. Eur J Ncurosci 1990:2:89-97.
13. Lynn B. Carpenter SE. Pini A: Capsaicin and cutaneous afferents; in Chahl LA. Szolcsanyi J. Lembeck F (eds): Antidromic Vasodilatation and Neurogenic Inflammation. Budapest. Akademiai Kiado. 1984. pp 83-92.
14. Lynn B. Effect of neonatal treatment with capsaicin on the numbers and properties of cutaneous afferent units from the hairy skin of the rat. Brain Res 1984;322:255-260.
15. Welk E. Fleischer E. Pctsche U. Handwerker HO: Afferent C-fibres in rats after neonatal capsaicin treatment. Pflugers Arch 1984:400:66-71.
16. Rang HP: The nociceptive afferent neurone as a target for new types of analgesic drug. Pain 1990:85:s249.
17. Tuckett RP. Wei JY: Response to an itch-producing substance in the cat. II.Cutaneous receptor populations with unmyelinated axons. Brain Res 1987;413:95-103.
18. Lang E. Novak A. Reeh PW. Handwerker HO: Chcmoscnsitivity of fine afferents from rat skin in vitro. J Neurophysiol 1990:63:887-901.
19. Burgess PR, Perl ER: Cutaneous mcchanorcceptors and nociceptors; in Iggo A (ed): Handbook of Sensory Physiol, vol 2: Somatosensory System. Berlin, Springer. 1973. pp 29-78.
20. Zotterman Y: Touch, pain and tickling: An electrophysiological investigation of cutaneous sensory nerves. J Physiol 1939:95:1-28.
21. Bessou P. Burgess P. Perl ER. Taylor CB: Dynamic properties of me-chanoreceptors with unmyelinated (C) fibres. J Neurophysiol 1971:34: 116-131.
22. Fjallbrandt N. Iggo A: The effect of histamine. 5-hydroxytryptaminc and acetylcholine on cutaneous afferent fibres. J Physiol 1961.156: 578-590.
23. Fitzgerald M: The sensitization of cutaneous nociceptors; PhD thesis University of London. 1978.
24. Lynn B. Carpenter SE: Primary afferent units from the hairy skin of the rat hind limb. Brain Res 1982; 238:29-43.
25. Nordin M: Low threshold mecha-norcccptivc and nociceptive units with unmyelinated (C) fibres in the human supraorbital nerve. J Physiol 1990:426:229-240.