Polymorphisms in the tumor necrosis factor α (TNF-α) gene correlate with murine resistance to development of toxoplasmic encephalitis and with levels of TNF-α mRNA in infected brain tissue

Journal of Experimental Medicine

Volumn 175, Issue 3, 1992, Pages 683-688

  Freund, Yvonne R ^a   Sgarlato, Gregory ^a   Jacob, Chaim O ^b   Suzuki, Yasuhiro ^c   Remington, Jack S ^a,d  

^a PALO ALTO MEDICAL FOUNDATION   (United States)

^b ROCHE BIOSCIENCE   (United States)

^c JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; DISEASE PREDISPOSITION; DISEASE RESISTANCE; DNA POLYMORPHISM; ENCEPHALITIS; GENE EXPRESSION REGULATION; INTRON; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; SOUTHERN BLOTTING; TOXOPLASMA;

ANIMAL; BASE SEQUENCE; BRAIN CHEMISTRY; ENCEPHALITIS; IMMUNITY, NATURAL; MICE; MICE, INBRED A; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; POLYMORPHISM (GENETICS); RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TOXOPLASMOSIS; TUMOR NECROSIS FACTOR;

EID: 0026581351     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.175.3.683     Document Type: Article

References (29)

1. Sharief, M.K., M. Phil, and K. Hentges. 1991. Association between tumor necrosis factor-α and disease progression in patients with multiple sclerosis. N. Engl. J. Med. 325:467.
2. Hofman, F.M., D.K. Hinton, K. Johnson, and J.E. Merrill. 1989. Tumor necrosis factor identified in multiple sclerosis brain. J. Exp. Med. 170:607.
3. Schijns, V.E., R. Van der Neut, B.L. Haagmans, D.R. Bar, H. Schellekens, and M.C. Hornzinek. 1991. Tumour necrosis factor-alpha, interferon-gamma and interferon-beta exert antiviral activity in nervous tissue cells, J Gen. Virol. 72:809.
4. Selmaj, K.W., and C.S. Raine. 1988. Tumor necrosis factor mediates myelin and oligondendrocyte damage in vitro. Ann. Neurol. 23:339.
5. Robbins, D.S., Y. Shirazi, B. Drysdale, A. Lieberman, H.S. Shin, and M.L. Shin. 1987. Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.J. Immunol. 139:2593.
6. Gran, G.E., L.F. Fajardo, P.F. Piguet, B. Allet, P.H. Lambert, and P. Vassalli. 1987. Tumor necrosis factor/cachectin as an essential mediator in murine cerebral malaria. Science (Wash. DC). 237:1210.
7. DeTitto, E.H., J.R. Catterall, andJ.S. Remington. 1986. Activity of recombinant tumor necrosis factor on Toxoplasma gondii and Trypanosoma cruzi. J. Immunol. 137:1342.
8. Black, C.M., D.M. Israelski, Y. Suzuki, andJ.S. Remington. 1989. Effect of recombinant tumor necrosis factor on acute infection in mice with Toxoplasma gondii or Trypanosoma cruzi. Immunology. 68:570.
9. Chang, H.R., G.E. Grau, and J.C. Pechère. 1990. Role of TNF and II.,1 in infections with Toxoplasma gondii. Immunology. 69:33.
10. Suzuki, Y., K. Joh, M.A. Orelhna, F.K. Conley, and J.S. Remington. 1991. Gene(s) within the H-2D region determine development of toxoplasmic encephalitis in mice. Immunology. In press.
11. + T cells determine cyst number in Toxoplasma gondii infection. J. Immunol. 145:3438.
12. Frenkel, J.K., and A. Escajadillo. 1987. Cyst rupture as a pathogenic mechanism of toxoplasmic encephalitis. Am.J. TroF Med. Hyg. 36:517.
13. Suzuki, Y., F.K. Conley, and J.S. Remington. 1989. Importance of endogenous IFN-γ for prevention of toxoplasmic encephalitis in mice. J. Immunol. 143:2045.
14. Müller, U., C.V. Jongeneel, S.A. Nedospasov, K.F. Lindahl, and M. Steinmetz. 1987. Tumour necrosis factor and lymphotoxin genes map close to the H-2D in the mouse major histocompatibility complex. Nature (Lond.). 325:265.
15. Jacob, C.O., and H.O. McDevitt. 1988. Tumour necrosis factor--x in murine autoimmune ‘Lupus’ nephritis. Nature (Lond.). 331:56.
16. Gardner, S.M., B.A. Mock, J. Hilgers, K.E. Huppi, and W.D. Roeder. 1987. Mouse lymphotoxin and tumor necrosis factor:structural analysis of the cloned genes, physical linkage and chromosomal position. J. Immunol. 139:476.
17. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, 2nd Ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
18. Feinberg, A.P., and B. Vogelstein. 1984. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 137:266.
19. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal. Biochem. 162:156.
20. Shakhov, A.N., M.A. Collart, P. Vassalli, S.A. Nedospasov, and C.V. Jongeneel. 1990. kB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages.J. Extx Med. 171:35.
21. Shirai, T., N. Shimizu, S. Shiojiri, S. Horiguchi, and H. Ito. 1988. Cloning and expression in Escherichia coli of the gene for mouse tumor necrosis factor. DNA (NY). 7:193.
22. Palmiter, R.D., E.P. Sandgren, M.R. Avarbock, D.D. Allen, and R.L. Brinster. 1991. Heterologous introns can enhance expression of transgenes in mice. Proc. Natl. Acad. Sci. USA. 88:478.
23. Messner, G., U. Spengler, M.C. Jung, G. Honold, K. Blomer, G.R. Pape, G. Riethmuller, and E.H. Weiss. 1991. Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-β gene correlates with a variant amino acid in position 26 and a reduced level of TNF-β production. J. Ex v Med. 173:209.
24. Botstein, D. 1980. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32:314.
25. Weber, J.L. 1990. Human DNA polymorphisms based on length variation in simple sequence tandem repeats. In Genomic Analysis. K.E. Davis and S.M. Tilghman, editors. Cold Spring Harbor Press, Cold Spring Harbor, NY. 159-181.
26. Jongened, C.V., H. Acha-Orbea, and T. Blankanstein. 1990. A polymorphic microsateUite in the tumor necrosis factor α promoter identifies an allele unique to the NZW mouse strain. J. Exp. Med. 171:2141.
27. Jacob, C.O., and F. Hwang. 1992. Definition ofmicrosatdlite size variants for TNF-α and HSP70 in autoimmune and nonautoimmune mouse strains. Immunogenetics. In press.
28. Chung, I.Y., J.G. Norris, and E.N. Benviste. 1991. Differential tumor necrosis factor-a expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains. J. Exp. Med. 173:801.
29. Lowe, D.G., and L.A. Moran. 1986. Molecular cloning and analysis of DNA complementary to three mouse Mr = 68,000 heat shock protein mRNAs. J. Biol. Chem. 261:2102.