Synthesis, Stability, and Biological Evaluation of Water-Soluble Prodrugs of a New Echinocandin Lipopeptide. Discovery of a Potential Clinical Agent for the Treatment of Systemic Candidiasis and Pneumocystis carinii Pneumonia (PCP)

Journal of Medicinal Chemistry

Volumn 35, Issue 1, 1992, Pages 194-198

  Balkovec, James M ^a   Black, Regina M ^a   Hammond, Milton L ^a   Heck, James V ^a   Zambias, Robert A ^a   Abruzzo, George ^a   Bartizal, Ken ^a   Kropp, Helmut ^a   Trainor, Charlotte ^a   Schwartz, Robert E ^a   McFadden, Diane C ^a   Nollstadt, Karl H ^a   Pittarelli, Lisa A ^a   Powles, Mary Ann ^a   Schmatz, Dennis M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; CILOFUNGIN; ECHINOCANDIN B; LIPOPEPTIDE; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CANDIDIASIS; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; HEMOLYSIS; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LETTER; MINIMUM INHIBITORY CONCENTRATION; MOUSE; PNEUMOCYSTIS CARINII; PNEUMONIA; PRIORITY JOURNAL; RAT;

ACETYLATION; ANIMAL; ANTIBIOTICS, ANTIFUNGAL; CANDIDIASIS; HUMAN; MICE; MICE, INBRED DBA; MICROBIAL SENSITIVITY TESTS; PEPTIDES; PNEUMONIA, PNEUMOCYSTIS CARINII; PRODRUGS; RATS; RATS, INBRED STRAINS;

EID: 0026575017     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00079a027     Document Type: Article

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