Interleukin 5 (IL-5) Provides a Signal That Is Required in Addition to ID4 for Isotype Switching to Immunoglobulin (Ig) G1 and IgE

Journal of Experimental Medicine

Volumn 175, Issue 4, 1992, Pages 973-982

  Purkerson, Jeffrey M ^a,b   Isakson, Peter C ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b MONSANTO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN M; INTERLEUKIN 4; INTERLEUKIN 5; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ARTICLE; B LYMPHOBLAST; CULTURE MEDIUM; FEMALE; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE PROLIFERATION; LYMPHOID CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMAL; ANTIBODY-PRODUCING CELLS; B-LYMPHOCYTES; GENE EXPRESSION REGULATION; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; INTERLEUKIN-4; INTERLEUKIN-5; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC;

EID: 0026574557     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.175.4.973     Document Type: Article

References (60)

1. Isakson, P.C., E. Pure, E.S. Vitetta, and P. Krammer. 1982. T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells. J. Exp Med. 155:734.
2. Noma, Y., P. Sideras, T. Naito, S. Bergstedt-Lindquist, C. Azuma, E. Severinson, T. Tanabe, T. Kinashi, F. Matsuda, Y. Yaoita, and T. Honjo. 1986. Cloning of cDNA encoding the murine IgGl induction factor by a novel strategy using SP6 promoter. Nature (Lond.). 319:640.
3. Coffman, R.L., J. Ohara, M.W. Bond, J. Carty, A. Zlotnick, and W.E. Paul. 1986. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J. Immunol. 136:4538.
4. Snapper, C.M., F.D. Finkelman, and W.E. Paul. 1988. Differential regulation of IgGl and IgE synthesis by interleukin 4. J. Exp Med. 167:183.
5. Stevens, T.L., A. Bossie, V.M. Sanders, R. Femandez-Botran, R.L. Coffman, T.R. Mosman, and E.S. Vitetta. 1988. Regulation of antibody isotype by subsets of antigen-specific helper T cells. Nature (Lond.). 334:255.
6. Lebman, D.A., and R.L. Coffman. 1988. Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures. J. Exp Med. 168:853.
7. Vercelli, D., H.H. Jabara, K.-I. Arai, and R.S. Geha. 1989. Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J. Exp Med. 169:1295.
8. DeKruyff, R.H., T. Turner, J.A. Abrams, M.A. Palladino, Jr., and D. Umatsu. 1989. Induction of human IgE synthesis by CD4 T cell clones. J. Exp Med. 170:1477.
9. Parronchi, P., A. Tiri, D. Macchia, M. De Carli, P. Biswas, C. Simonelli, E. Maggi, G. Del Prete, M. Ricci, and S. Romag-nani. 1991. Noncognate contact-dependent B cell activation can promote IL-4 dependent in vitro human IgE synthesis. J. Immunol. 144:2102.
10. Gascan, H., J.-F. Gauchat, M.-G. Roncarolo, H. Yssel, H. Spits, and J.E. de Vries. 1991. Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4 T cell clones. J. Exp Med. 173:747.
11. Lundgren, M., U. Persson, P. Larsson, C. Magnus son, C.I.E. Smith, L. Hammarstrom, and E. Severinson. 1989. Interleukin 4 induces synthesis of IgE and IgG in human B cells. Eur. J. Immunol. 19:1311.
12. Thyphronitis, G., G.C. Tsokos, C.H. June, A.D. Levine, and F.D. Finkelman. 1989. IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon y. Proc Natl. Acad. Sei. USA. 86:5580.
13. Jabara, H.H., S.M. Fu, R.S. Geha, and D. Vercelli. 1990. CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J. Exp Med. 172:1861.
14. Rousset, F., E. Garcia, and J. Banchereau. 1991. Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen. J. Exp Med. 173:705.
15. Wu, C.Y., M. Sarfati, C. Heusser, S. Fournier, M. Rubio-Trujillo, R. Feleman, and G. Delespesse. 1991. Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4-stimulated human lymphocytes. J. Clin. Invest. 87:870.
16. Jabara, H.H., D.J. Ahem, D. Vercelli, and R.F. Geha. 1991. Hydrocortisone and IL4 induce IgE isotype switching in human B cells. J. Immunol. 147:1557.
17. Finkelman, F.D., I.M. Katona, J.F. Urban, Jr., J. Holmes, J. Ohara, A.S. Tung, J.vG. Sample, and W.E. Raul. 1988. IL-4 is required to generate and sustain in vivo IgE response. J. Immunol. 141:2335.
18. Finkelman, F.D., J.F. Urban, Jr., M.R Beckmann, J.M. Holmes, and J.M. Katona. 1991. Regulation of murine in vivo IgG and IgE response by a monoclonal anti-IL-4 receptor antibody. Int. Immunol. 3:599.
19. Tepper, R.I., D.A. Levinson, B.Z. Stanger, J. Campos-Torres, A.K. Abbas, and P. Leder. 1990. IL4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell. 62:457.
20. Kuhn, R., K. Rajewsky, and W. Muller. 1991. Generation and analysis of interleukin-4 deficient mice. Science (Wash. DC). 254:707.
21. Burstein, H.J., R.I. Tepper, P. Leder, and A.K. Abbas. 1991. Humoral immune functions in IL4 transgenic mice.J. Immunol. 147:2950.
22. Schmitz, J., and A. Radbruch. 1989. An interleukin 4-induced DNase I hypersensitive site indicates opening of the yl switch region prior to switch recombination. Int. Immunol. 1:13.
23. Berton, M.T., and E.S. Vitetta. 1990. Interleukin 4 induces changes in the chromatin structure of the yl switch region in resting B cells before switch recombination. J. Exp Med. 172:375.
24. Berton, M.T., J.W. Uhr, and E.S. Vitetta. 1989. Synthesis of germ-line yl immunoglobulin heavy-chain transcripts in resting B cells: Induction by interleukin 4 and inhibition by interferon y. Proc Natl. Acad. Sei. USA. 86:2829.
25. Esser, C., and A. Radbruch. 1989. Rapid induction of transcription of unrearranged Syl switch regions in activated murine B cells by interleukin 4. EMBO (Eur. Mol. Biol. Organ.) J. 8:483.
26. Rothman, P., S. Lutzker, W. Cook, R. Coffman, and F.W. Alt. 1988. Mitogen plus interleukin 4 induction of C, transcripts in B lymphoid cells. J. Exp Med. 168:2385.
27. Stavnezer, J., G. Radcliffe, Y. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severin son. 1988. Immunoglobulin heavy chain switching may be directed by prior induction of transcripts from constant region genes. Proc NatL Acad. Sei. USA. 85:7704.
28. Lutzker, S., P. Rothman, R. Pollock, R. Coffman, and F.W. Alt. 1988. Mitogen- and IL4-regulated expression of germ-line Ig y2b transcripts: Evidence for directed heavy chain class switching. Cell. 53:177.
29. Hodgkin, P.D., L.C. Yamashita, R.L. Coffman, and M.R. Kehry. 1990. Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lym-phokines. J. Immunol. 145:2025.
30. Rothman, P., Y Chen, S. Lutzker, S.C. Li, V. Stewart, R. Coffman, and F.W. Alt. 1990. Structure and expression of germ-line immunoglobulin heavy-chain e transcripts: Interleukin-4 plus lipopolysaccharide-directed switching to Ce. Mol. Cell. Biol. 10:1672.
31. Jabara, H.H., L.C. Schneider, S.K. Shapira, C. Alfieri, C.T. Moody, E. Kieff, R.S. Geha, and D. Vercelli. 1990. Induction of germ-line and mature C, transcripts in human B cells stimulated with rIL-4 and EBV. J. Immunol. 145:3468.
32. Gascan, H., J. Gauchat, G. Aversa, P.V. Vlasselaer, and J.E. De Vries. 1991. Anti-CD40 monoclonal antibodies or CD4 T cell clones and IL-4 induce IgG« and IgE switching in purified human B cells via different signaling pathways./. Immunol. 147:8.
33. Purkerson, J.M., M. Newberg, G. Wise, K.R. Lynch, and P.C. Isakson. 1988. Interleukin 5 and interleukin 2 cooperate with interleukin 4 to induce IgGl secretion from anti-Ig-treated B cells. J. Exp Med. 168:1175.
34. McHeyzer-Williams, M.G. 1989. Combinations of interleukins 2, 4, and 5 regulate the secretion of murine immunoglobulin isotypes. Eur. J. Immunol. 19:2025.
35. Purkerson, J., and P.C. Isakson. 1991. Isotype switching in anti-immunoglobulin activated B lymphoblasts: differential requirements for interleukin-4 and other lymphokines to elicit membrane vs. secreted IgGj. Eur. J. Immunol. 21:707.
36. Pene, J., F. Rousset, F. Briere, I. Chretien, J. Wademan, J.Y. Bonnefory, and J.E. De Vries. 1988. Interleukin-5 enhances interleukin-4 induced IgE production by normal human B cells. The role of soluble CD23 antigen. Eur. J. Immunol. 18:929.
37. Vercelli, D., H.H. Jabara, K. Arai, T. Yokota, and R.S. Geha. 1989. Endogenous interleukin 6 plays an obligatory role in interleukin 4-dependent human IgE synthesis. Eur. J. Immunol. 19:1419.
38. DeKruyff, R.H., T.R. Mosmann, and D.T. Umetsu. 1990. Induction of antibody synthesis by CD4 T cells: IL-5 is essential for induction of antigen-specific antibody responses by T„2 but not T„1 clones. Eur. J. Immunol. 20:2219.
39. Isakson, P.C., D. D’Angelo, J. Schetz, L. Tardelli, and E. Pure. 1989. Anti-Ig-stimulated B lymphoblasts can be restimulated via their surface Ig. J. Immunol. 143:3901.
40. Isakson, P.C. 1986. Antiimmunoglobulin-treated B cells respond to a B cell differentiation factor for IgGl.J. Exp Med. 164:303.
41. Summers, M.D., and G.E. Smith. 1987. A manual of methods for Baculovirus vectors and insect cell culture procedures. Tex. Agric Exp St. Bull. No. 1555.
42. Birkeland, M.L., L. Simpson, P.C. Isakson, and E. Pure. 1987. T-independent and T-dependent steps in the murine B cell response to antiimmunoglobulin. J. Exp Med. 166:506.
43. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:55.
44. Chirgwin, J., A. Pryzbyla, R. McDonald, and W. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294.
45. Melton, D.A., P.A. Krieg, M.R. Rebagliati, K. Maniatis, T. Zinn, and M.R. Green. 1984. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12:7035.
46. Mowatt, M., C. Dery, and W. Dunnick. 1985. Unique sequences are interspersed among tandemly repeated elements in the murine 7I switch segment. Nucleic Acids Res. 13:225.
47. Xu, M., and J. Stavnezer. 1990. Structure of germline immunoglobulin 7I heavy-chain transcripts in interleukin 4 treated mouse spleen cells. Dev. Immunol. 1:11.
48. Ishida, N., S. Ueda, H. Hayashida, T. Miyata, and T. Honjo. 1982. The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence. EMBO (Eur. Mol. Biol. Organ.) J. 1:1117.
49. Simpson, L., I. McNiece, M. Newberg, J. Schetz, K.R. Lynch, P. Quesenberry, and P.C. Isakson. 1989. Detection and characterization of a B cell stimulatory factor (BSF-TC) derived from a bone marrow stromal cell line. J. Immunol. 142:3894.
50. Gerondakis, S. 1990. Structure and expression of murine germ-line immunoglobulin e heavy chain transcripts induced by interleukin 4. Proc Natl. Acad. Sci. USA. 87:1581.
51. Noelle, R.J., J. Daum, W.C. Bartlett, J. McCann, and D.M. Shepherd. 1991. Cognate interactions between helper T cells and B cells. V. Reconstitution of T helper cell function using purified plasma membranes from activated Thl and Th2 T helper cells and lymphokines. J. Immunol. 146:1118.
52. Tonkonogy, S.L., D.T. McKenzie, and S.L. Swain. 1989. Regulation of isotype production by IL-4 and IL-5: effects of lymphokines on Ig production depend on the state of activation of the responding cells. J. Immunol. 142:4351.
53. Matsumoto, M., A. Tominaga, N. Harada, and K. Takatsu. 1987. Role of T cell-replacing factor (TRF) in the murine B cell differentiation: Induction of increased levels of expression of secreted type IgM mRNA. J. Immunol. 138:1826.
54. Webb, C.F., C. Das, R.L. Coffman, and P.W. Tucker. 1989. Induction of immunoglobulin fi mRNA in a B cell transfec-tant stimulated with interleukin-5 and a T-dependent antigen. J. Immunol. 143:3934.
55. Matsui, K., K. Nakanishi, D.I. Cohen, T. Hada, J. Furuyama, T. Hamaoka, and K. Higashino. 1989. B cell response pathways regulated by IL-5 and IL-2: secretory fiH chain-mRNA and J chain mRNA expression are separately controlled events.J. Immunol. 142:2918.
56. Yuan, D., T. Dang, and C. Sanderson. 1990. Regulation of IgH chain gene transcription by IL-5. J. Immunol. 144:3491.
57. Ohara, J., and W.E. Paul. 1987. Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature (Land.). 325:537.
58. Mosley, B., M.P. Beckman, C.J. March, R.L. Idzerda, S.D. Gimpel, T. VandenBos, D. Friend, A. Alpert, D. Anderson, J. Jackson, et al. 1989. The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane forms. Cell. 59:335.
59. Femandez-Botran, R., J.W. Uhr, and E.S. Vitetta. 1989. Crosslinking of interleukin 4 to surface molecules on murine T and B lymphocytes. Proc Natl. Acad. Sci. USA. 86:4235.
60. Snapper, C.M., L.M.T. Pecanha, A.D. Levine, and J.J. Mond. 1991. IgE class switching is critically dependent upon the nature of the B cell activator, in addition to the presence of IL4. J. Immunol. 147:1163