Elevated glucose decreases the content of a basement membrane associated heparan sulphate proteoglycan in proliferating cultured porcine mesangial cells

Diabetologia

Volumn 35, Issue 2, 1992, Pages 183-186

  Olgemoller B ^a   Schwaabe, S ^a   Gerbitz, K D ^a   Schleicher, E D ^a  

^a Klinikum Schwabing   (Germany)

Author keywords

Diabetes mellitus; glomerular mesangial cells; heparan sulphate proteoglycan; hyperglycaemia; nephropathy

Indexed keywords

FIBRONECTIN; GLUCOSE; HEPARAN SULFATE; SORBITOL;

ANIMAL CELL; ARTICLE; BASEMENT MEMBRANE; CONTROLLED STUDY; DIABETIC NEUROPATHY; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMAL; BASEMENT MEMBRANE; CELL DIVISION; CELLS, CULTURED; FIBRONECTINS; GLOMERULAR MESANGIUM; GLUCOSE; HEPARAN SULFATE PROTEOGLYCAN; HEPARITIN SULFATE; INSULIN; KINETICS; PROTEOGLYCANS; SORBITOL; SUPPORT, NON-U.S. GOV'T; SWINE;

EID: 0026570385     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/BF00402553     Document Type: Article

References (10)

1. Kidney disease of diabetes mellitus: the contribution of glomerular mesangial cells to the glomerulosclerosis
2. Glucose enhances type IV collagen production in cultured rat glomerular mesangial cells
3. Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium
4. Alterations in the basement membrane (heparan sulphate) proteoglycan in diabetic mice
5. Characterization and localization of basement membrane-associated heparan sulphate proteoglycan in human tissues
6. Isolation, characterization and immunological determination of basement membrane-associated heparan sulphate proteoglycan
7. Glomerular cell culture
8. Studies on macromolecular components of human glomerular basement membrane and alterations in diabetes: decreased levels of heparan sulphate proteoglycan and laminin
9. Altered steady-state in mRNA levels of basement membrane proteins in diabetic mouse kidneys and thromboxane synthase inhibition
10. Response of diabetic basement membrane-producing cells to glucose and insulin