Long-term agonist exposure induces upregulation of β3-adrenergic receptor expression via multiple cAMP response elements

Proceedings of the National Academy of Sciences of the United States of America

Volumn 89, Issue 10, 1992, Pages 4490-4494

  Thomas, R F ^a   Holt, B D ^a   Schwinn, D A ^a   Liggett, S B ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

adenylyl cyclase; adipocyte; desensitization; downregulation; transcription

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHLORAMPHENICOL ACETYLTRANSFERASE; CYCLIC AMP DERIVATIVE; ISOPRENALINE;

ADIPOCYTE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DNA FLANKING REGION; DRUG EXPOSURE; DRUG MECHANISM; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VERO CELL;

1-METHYL-3-ISOBUTYLXANTHINE; 3T3 CELLS; ANIMAL; BASE SEQUENCE; CELL NUCLEUS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CYCLIC AMP; GENE EXPRESSION; IODOCYANOPINDOLOL; ISOPROTERENOL; KINETICS; MICE; MOLECULAR SEQUENCE DATA; OLIGODEOXYRIBONUCLEOTIDES; PINDOLOL; POLYMERASE CHAIN REACTION; RECEPTORS, ADRENERGIC, BETA; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION; VERO CELLS;

EID: 0026568787     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.89.10.4490     Document Type: Article

References (0)