Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH

Journal of Cellular Physiology

Volumn 151, Issue 2, 1992, Pages 386-394

  Casciari, Joseph J ^a   Sotirchos, Stratis V ^a   Sutherland, Robert M ^a,b  

^a UNIVERSITY OF ROCHESTER   (United States)

^b SRI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; OXYGEN;

ANIMAL CELL; ARTICLE; BREAST TUMOR; CELL METABOLISM; EXTRACELLULAR FLUID; MICROELECTRODE; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PH; PRIORITY JOURNAL; TUMOR CELL LINE; TUMOR GROWTH;

ANIMAL; CELL DIVISION; EXTRACELLULAR SPACE; GLUCOSE; HYDROGEN-ION CONCENTRATION; MAMMARY NEOPLASMS, EXPERIMENTAL; MODELS, BIOLOGICAL; OSMOLAR CONCENTRATION; OXYGEN CONSUMPTION; SARCOMA, EXPERIMENTAL; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0026568374     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.1041510220     Document Type: Article

References (36)

1. Influence of glucose and buffer capacity in the culture medium on growth and pH in spheroids of human thyroid carclnoma and human glioma origin
2. The effect of prolonged hypoxia on growth and viability of Chinese hampster cells
3. Glucose diffusivity in multicellular tumor spheroids
4. pH as a determinant of cellular growth and contact inhibition
5. In situ determination of mycoplasma contamination in cell cultures by fluorescent Hoechst 33528 stain
6. A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth
7. Proliferative and clonogenic heterogeneity of cells from EMT6/Ro multicellular spheroids induced by the glucose and oxygen supply
8. The respiration of ascites tumor cells at low oxygen concentrations
9. 2 values
10. The internal milieu of tumors
11. Induction characteristics of oxygen regulated proteins
12. 2 supply in hepatocytes
13. Oxygen effects in radiobiology
14. Respiration of mammalian cells at low concentrations of oxygen: the effect of hypoxic cell radiosensitizing drugs
15. The glucose distribution in 9L rat brain multicell tumor spheroids and its effect on cell necrosis
16. Nutrient modification of proliferation and radiation response in EMT6/Ro spheroids
17. Measurement of low levels of oxygen and their effects on respiration in cell suspensions maintained in an open air system
18. Oxygen tensions in multicell spheroids of two cell lines
19. Evidence for a major role of glucose in controlling development of necrosis in EMT6/Ro multicell tumor spheroids
20. Method of determining oxygen concentrations in biological media suitable for calibration of oxygen electrodes
21. Intracapillary HbO2 saturation in murine tumors and human tumor xenografts measured by cryospectrophotometry: Relationship to tumor volume, pH, and fraction of radiobiologically hypoxic cells
22. Influence of hypoxia and acid environment on the metabolism and viability of cultured cells; potential implications of cell death in tumors
23. Effects of extreme hypoxia on the growth and viability of EMT6/SF mouse tumor cells in vitro
24. Oxygenation and differentiation in multicellular spheroids of human colon carcinoma
25. Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma
26. Blood flow, oxygen consumption, and tissue oxygenation of human breast cancer xenografts in nude rats
27. pH dependence of aerobic glycolysis in Ehrlich ascites tumor cells
28. The oxygen dependence of cellular energy metabolism