Inhibition of human neutrophil protein kinase C activity by the antimalarial drug mefloquine

Biochemical Pharmacology

Volumn 43, Issue 3, 1992, Pages 527-532

  El Benna, Jamel ^a   Hakim, Jacques ^a   Labro, Marie Thérèse ^a  

^a BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIMALARIAL AGENT; HISTONE; MEFLOQUINE; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL DIBUTYRATE; PHOSPHATIDYLSERINE; PROTEIN KINASE C; RADIOLIGAND; SUPEROXIDE;

ARTICLE; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIGAND BINDING; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VOLUNTEER;

DOSE-RESPONSE RELATIONSHIP, DRUG; HUMAN; KINETICS; MEFLOQUINE; NEUTROPHILS; PHORBOL 12,13-DIBUTYRATE; PHOSPHORYLATION; PROTEIN KINASE C; RESPIRATORY BURST; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE;

EID: 0026567981     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(92)90574-3     Document Type: Article

References (36)

1. Studies and perspectives of protein kinase C
2. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
3. Relationship of glycolytic and oxidative metabolism to particle entry and destruction in phagocytosing cells
4. Activity and activation of the granulocyte superoxide-generating system
5. 2-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function
6. Localization of the 47 kDa phosphoprotein involved in the respiratory-burst NADPH oxidase of phagocytic cells
7. Protein phosphorylation associated with the stimulation of neutrophils. Modulation of superoxide production by protein kinase C and calcium
8. Inhibition of neutrophil superoxide formation by 1-(5-isoquino-linesulfonyl)-2-methylpiperazine (H-7), an inhibitor of protein kinase-C
9. Inhibition of oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst
10. Effects of amod-iaquine, chloroquine, and mefloquine on human polymorphonuclear neutrophil function in vitro
11. Depression of human polymorphonuclear leucocyte function by anti-malarial drugs
12. Activation of the guinea pig-granulocyte NADPH-dependent superoxide enzyme; localization in plasma membrane enriched particle and kinetics of activation
13. Rapid down-regulation of protein kinase C in (chediak-higashi syndrome) beige mouse by phorbol ester
14. Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties
15. Rapid assay of binding of tumor-promoting phorbol esters to protein kinase C
16. Relationship of protein phosphorylation to the activation of the respiratory burst in human neutrophils
17. Cleavage of structural proteins during the assembly of head of bacteriophage T4
18. Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH) oxidase by protein kinase C
19. Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme
20. ++ dependent protein kinase
21. The antimalarial drug mefloquine binds to membrane phospholipids
22. The lipid binding regulatory domain of protein kinase C
23. Sphingosine inhibition of protein kinase C activity and phorbol dibutyrate binding in vitro and in human platelets
24. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
25. Inhibition of rodent protein kinase C by the anticarcinoma agent dequalinium
26. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains
27. cAMP-dependent protein kinase: model for an enzyme family
28. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C
29. ++-dependent protein kinases in Plasmodium falciparum
30. Phorbol esters specifically enhance the cytolytic activity of Entamoeba hystolytica
31. Neurologic reactions after a therapeutic dose of mefloquine
32. The role of protein kinase C in transmembrane signalling
33. Phosphorylation of B-50 (GAP 43) is correlated with neurotransmitter release in rat hippocampal slices
34. The mechanism of action of protein kinase C; new insights through the study of inhibitors and gene cloning
35. Protein kinase C—a novel target for rational anti-cancer drug design?