Nearly ubiquitous tissue distribution of the scrapie agent precursor protein

Neurology

Volumn 42, Issue 1, 1992, Pages 149-156

  Bendheim, P E ^a,e   Brown, H R ^b   Rudelli, R D ^c   Scala, L J ^a   Goller, N L ^b   Wen, G Y ^b   Kascsak, R J ^d   Cashman, N R ^f   Bolton, D C ^a  

^a CMSV Campus   (United States)

^b Departments of Pathology and Urology   (United States)

^c Departments of Virology   (United States)

^d NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^e SUNY DOWNSTATE MEDICAL CENTER   (United States)

^f MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; CELL PROTEIN; PROTEIN PRECURSOR; VIRUS PROTEIN;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HAMSTER; IMMUNOHISTOCHEMISTRY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN VARIANT; SCRAPIE; SCRAPIE AGENT; TISSUE DISTRIBUTION;

ANIMAL; BRAIN; HAMSTERS; IMMUNOHISTOCHEMISTRY; LUNG; MICROSCOPY, IMMUNOELECTRON; PRIONS; PRPSC PROTEINS; SPINAL CORD; STOMACH; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TISSUE DISTRIBUTION;

EID: 0026567814     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/wnl.42.1.149     Document Type: Article

References (58)

1. Carp RI, Kascsak RJ, Wisniewski HM, et al. The nature of the unconventional slow infection agents remains a puzzle. Alzheimer Dis Assoc Disord 1989;3:79-99.
2. Bolton DC, McKinley MP, Prusiner SB. Identification of a protein that purifies with the scrapie prion. Science 1982;218:1309-1311.
3. Bendheim PE, Barry RA, DeArmond SJ, Stites DP, Prusiner SB. Antibodies to a scrapie prion protein. Nature 1984;310:418-421.
4. Bolton DC, Bendheim PE, Marmorstein AD, Potempska A. Isolation and structural studies of the intact scrapie agent protein. Arch Biochem Biophys 1987;258:579-590.
5. Merz PA, Kascsak RJ, Rubenstein R, Carp RI, Wisniewski HM. Antisera to scrapie-associated fibril protein and prion protein decorate scrapie-associated fibrils. J Virol 1987;61:42-49.
6. Prusiner SB, Groth DF, Bolton DC, Kent SB, Hood LE. Purification and structural studies of a major scrapie prion protein. Cell 1984;38:127-134.
7. McKinley MP, Bolton DC, Prusiner SB. A protease-resistantprotein is a structural component of the scrapie prion. Cell 1983;35:57-62.
8. Carlson GA, Kingsbury DT, Goodman PA, et al. Linkage of prion protein and scrapie incubation time genes. Cell 1986;46:503-511.
9. Hope J, Reekie LJD, Hunter N, et al. Fibrils from brains of cows with new cattle disease contain scrapie-associated protein. Nature 1988;336:390-392.
10. Scott M, Foster D, Mirenda CA, et al. Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell 1990;59:847-857.
11. Hsiao KK, Scott M, Foster D, Groth DF, DeArmond SJ, Prusiner SB. Spontaneous neurodegeneration in transgenic mice with mutant prion protein. Science 1990;250:1587-1590.
12. Oesch B, Westaway D, Walchli M, et al. A cellular gene encodes scrapie PrP 27-30 protein. Cell 1985;40:735-746.
13. Chesebro B, Race R, Wehrly K, et al. Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain. Nature 1985;315:331-333.
14. Cashman NR, Loertscher R, Nalbantoglu J, et al. Cellular isoform of the scrapie agent protein participates in lymphocyte activation. Cell 1990;61:185-192.
15. Bendheim PE, Potempska A, Kascsak RJ, Bolton DC. Purification and partial characterization of the normal cellular homologue of the scrapie agent protein. J Infect Dis 1988;158:1198-1208.
16. Bolton DC, Bendheim PE. A modified host protein model of scrapie. Ciba Found Symp 1988;135:164-181.
17. Hsiao K, Baker HF, Crow TJ, et al. Linkage of a prion protein missense variant to Gerstmann-Straussler syndrome. Nature 1989;338:342-345.
18. Kimberlin RH, Walker CA. Pathogenesis of experimental scrapie. Ciba Found Symp 1988;135:37-62.
19. Kimberlin RH, Walker CA. Pathogenesis of mouse scrapie: dynamics of agent replication in spleen, spinal cord and brain after infection by different routes. J Comp Pathol 1979;89:551-562.
20. Pattison IH, Millson GC. Distribution of the scrapie agent in the tissues of experimentally inoculated goats. J Comp Pathol 1962;72:233-244.
21. Manuelidis EE, Gorgacs EJ, Manuelidis L. Viremia in experimental Creutzfeldt-Jakob disease. Science 1978;200:1069-1071.
22. Hadlow WJ, Kennedy RC, Race RE. Natural infection of Suffolk sheep with scrapie virus. J Infect Dis 1982;146:657-664.
23. Bruce ME. Agent replication dynamics in a long incubation period model of mouse scrapie. J Gen Virol 1985;66:2517-2522.
24. Meyer RK, McKinley MP, Bowman KA, Braunfeld MB, Barry RA, Prusiner SB. Separation and properties of cellular and scrapie prion proteins. Proc Natl Acad Sci USA 1986;83:2310-2314.
25. Turk E, Teplow DB, Hood LE, Prusiner SB. Purification and properties of the cellular and scrapie hamster prion proteins. Eur J Biochem 1988;176:21-30.
26. Caughey B, Race RE, Chesebro B. Detection of prion protein mRNA in normal and scrapie-infected tissues and cell lines. J Gen Virol 1988;69:711-716.
27. Brown HR, Goller NL, Rudelli RD, et al. The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells. Acta Neuropathol (Berl) 1990;80:1-6.
28. Kascsak RJ, Rubenstein R, Merz PA, et al. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol 1987;61:3688-3693.
29. Barry RA, Kent SB, McKinley MP, et al. Scrapie and cellular prion proteins share polypeptide epitopes. J Infect Dis 1986;153:848-854.
30. Bolton DC, Seligman SJ, Bablanian G, et al. Molecular location of a species-specific epitope on the hamster scrapie agent protein. J Virol 1991;65:3667-3675.
31. Lowenstein DH, Butler DA, Westaway D, McKinley MP, DeArmond SJ, Prusiner SB. Three hamster species with different scrapie incubation times and neuropathological features encode distinct prion proteins. Mol Cell Biol 1990;10:1153-1163.
32. Barry RA, McKinley MP, Bendheim PE, Lewis GK, DeArmond SJ, Prusiner SB. Antibodies to the scrapie protein decorate prion rods. J Immunol 1985;135:603-613.
33. Bendheim PE, Bolton DC. A 54-kDa normal cellular protein may be the precursor of the scrapie agent protease-resistant protein. Proc Natl Acad Sci U S A 1986;83:2214-2218.
34. Kascsak RJ, Rubenstein R, Merz PA, et al. Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains. J Virol 1986;59:676-683.
35. Knigge KM, Joseph SA. A stereotaxic atlas of the brain of the golden hamster. In: Hoffman RA, Robinson PF, Magalhaes H, eds. The golden hamster. Ames, IA: Iowa State University Press, 1968:285-319.
36. Kim KS, Miller DL, Sapienza VJ, et al. Production and characterization of monoclonal antibodies to synthetic cerebrovascular amyloid peptide. Neurosci Res Commun 1988;2:121-130.
37. Bienz K, Egger D, Pasamontes L. Electron microscopic immu- nocytochemistry: silver enhancement of colloidal gold marker allows double labeling with the same primary antibody. J Histo- chem Cytochem 1986;34:1337-1342.
38. DeArmond SJ, Mobley WC, DeMott DL, Barry RA, Beckstead JH, Prusiner SB. Changes in the localization of brain prion proteins during scrapie infection. Neurology 1987;37:1271-1280.
39. MacLean PD. Fiber systems of the forebrain. In: Paxinos G, ed. The rat nervous system, vol. 1. Sydney: Academic Press, 1985:435.
40. Kennedy AR, Desrosiers A, Terzaghi M, Little JB. Morphometric and histological analysis of the lungs of Syrian golden hamsters. J Anat 1978;125:527-553.
41. Diedrich JF, Bendheim PE, Kim KS, Carp RI, Haase AT. Scrapie-associated prion protein accumulates in astrocytes during scrapie infection. Proc Natl Acad Sci USA 1991;88:375-379.
42. Bruce ME, McBride PA, Farquhar CF. Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie. Neurosci Lett 1989;102:1-6.
43. Parry HB. Scrapie disease in sheep. New York: Academic Press, 1983.
44. Oleszak EL, Murdoch G, Manuelidis L, Manuelidis EE. Growth factor production by Creutzfeldt-Jakob disease cell lines. J Virol 1988;62:3103-3108.
45. Hay B, Prusiner SB, Lingappa VR. Evidence for a secretory form of the cellular prion protein. Biochemistry 1987;26:8110-8115.
46. Lopez CD, Yost CS, Prusiner SB, Myers RM, Lingappa VR. Unusual topogenic sequence directs prion protein biogenesis. Science 1990;248:226-229.
47. Harris DA, Falls DL, Johnson FA, Fischbach GD. A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity. Proc Natl Acad Sci USA 1991;88:7664-7668.
48. Usdin TB, Fischbach GD. Purification and characterization of a polypeptide from chick brain that promotes the accumulation of acetylcholine receptors in chick myotubes. J Cell Biol 1986;103:493-507.
49. Rotter A. Cholinergic receptors. In: Bjorkland A, Hokfeldt T, Kuhar MJ, eds. Handbook of chemical neuranatomy, vol. 3. Amsterdam: Elsevier, 1984:273-303.
50. Schulman JA. Chemical neuroanatomy of the cerebellar cortex. In: Emson PC, ed. Chemical neuroanatomy. New York: Raven Press, 1983:209-228.
51. Mobley WC, Neve RL, Prusiner SB, McKinley MP. Nerve growth factor increases mRNA levels for the prion protein and the beta- amyloid protein precursor in developing hamster brain. Proc Natl Acad Sci U S A 1988;85:9811-9815.
52. Eklund CM, Kennedy RC, Hadlow WJ. Pathogenesis of scrapie virus infection in the mouse. J Infect Dis 1967;117:15-22.
53. Bosanquet FD, Daniel PM, Parry HB. Myopathy in sheep: its relationship to scrapie and to dermatomyositis and muscular dystrophy. Lancet 1956;2:737-746.
54. Griffith JS. Self-replication and scrapie. Nature 1967;215:1043-1044.
55. Millson GC, Kimberlin RH, Manning EJ, Collis SC. Early distribution of radioactive liposomes and scrapie infectivity in mouse tissues following administration by different routes. Vet Microbiol 1979;4:89-99.
56. Joachim CL, Mori H, Selkoe DJ. Amyloid beta-protein deposition in tissues other than brain in Alzheimer’s disease. Nature 1989;341:226-230.
57. Ikegami Y, Ito M, Isomura H, et al. Pre-clinical and clinical diagnosis of scrapie by detection of PrP protein in tissues of sheep. Vet Rec 1991;128:271-275.
58. Bolton DC, Rudelli RD, Currie JR, Bendheim PE. Copurification of Sp33-37 and scrapie agent from hamster brain prior to detectable histopathology and clinical disease. J Gen Virol (in press).