Antibody framework residues affecting the conformation of the hypervariable loops

Journal of Molecular Biology

Volumn 224, Issue 2, 1992, Pages 487-499

  Foote, Jefferson ^a   Winter, Greg ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

humanized antibody; hypervariable loop; kinetics; lysozyme; site directed mutagenesis

Indexed keywords

RODENTIA;

LYSOZYME; MONOCLONAL ANTIBODY; PROTEIN ANTIBODY; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ANTIBODY STRUCTURE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BINDING AFFINITY; BINDING KINETICS; DISSOCIATION CONSTANT; EQUILIBRIUM CONSTANT; FLUORESCENCE; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANIMAL; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; BINDING SITES, ANTIBODY; CRYSTALLOGRAPHY; DNA; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOGLOBULINS, HEAVY-CHAIN; KINETICS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MURAMIDASE; MUTATION; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE; SUPPORT, NON-U.S. GOV'T; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0026559783     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2836(92)91010-M     Document Type: Article

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