Mechanism of action of foscarnet against viral polymerases

The American Journal of Medicine

Volumn 92, Issue 2 SUPPL. 1, 1992, Pages

  Crumpacker, Clyde S ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; DNA POLYMERASE; FOSCARNET; GANCICLOVIR; PHOSPHONOACETIC ACID; RNA DIRECTED DNA POLYMERASE;

ANTIVIRAL ACTIVITY; CELL GROWTH; CONFERENCE PAPER; CYTOMEGALOVIRUS; DRUG MECHANISM; DRUG RESISTANCE; HERPES SIMPLEX VIRUS; HERPES VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL; RETINITIS; VARICELLA ZOSTER VIRUS; VIRUS RESISTANCE;

ANTIVIRAL AGENTS; DNA-DIRECTED DNA POLYMERASE; DNA-DIRECTED RNA POLYMERASES; DRUG INTERACTIONS; DRUG RESISTANCE, MICROBIAL; FOSCARNET; GANCICLOVIR; HERPESVIRIDAE; HIV; HIV-1 REVERSE TRANSCRIPTASE; HUMAN; PHOSPHONOACETIC ACID; REVERSE TRANSCRIPTASE INHIBITORS; SIMPLEXVIRUS;

EID: 0026553933     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/0002-9343(92)90329-A     Document Type: Article

References (37)

1. Physical mapping of the PAAR mutations of herpes simplex virus type 1 and type 2 by intertypic marker rescue
2. Physical and genetic analysis of the herpes simplex virus DNA polymerase locus
3. Resistance of herpes simplex virus to acycloguanosine: genetic and physical analysis
4. Molecular targets of antiviral therapy
5. Trisodium phosphonoformate, a new antiviral compound
6. Characteristics of herpes virus mutants resistant to phosphonoformate and phosphonoacetate
7. Pyrophosphate analogues as inhibitors of DNA polymerases of cytomegalovirus, herpes simplex virus and cellular origin
8. Molecular basis of foscarnet action
9. Mechanism of inhibition of Epstein-Barr virus replication by phosphonoformic acid
10. Inhibition of cytomegalovirus late antigens by phosphonoformate
11. Reversible inhibition of cytomegalovirus replication by phosphonoformate
12. Characterization of the DNA polymerase included by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid
13. Pyrophosphate analogues as inhibitors of herpes simplex virus type I DNA polymerase
14. Properties of herpes simplex virus type 1 and type 2 DNA polymerase
15. Mechanism of phosphonoacetate inhibition of herpes virus induced DNA polymerase
16. Physical mapping of drug resistance mutations defines as active center of the herpes simplex virus DNA polymerase enzyme
17. Foscarnet: a review of its antiviral activity, pharmacokinetic properties, and therapeutic use in immunocompromised patients with cytomegalovirus retinitis
18. Inhibition of human T-cell lymphotrophic virus type III in vitro by phosphonoformate
19. Inhibition of HTLV-III/LAV replication by foscarnet
20. Viral resistance to human immunodeficiency virus type I-specific pyridinone reverse transcriptase inhibitors
21. Phosphonoformate and phosphonoacetate
22. Treatment of experimental herpes virus infections with phosphonoformate and some comparisons with phosphonoacetate
23. Nucleic acid hybridization for measurement of effects of antiviral compounds on human cytomegalovirus DNA replication
24. 1 analogs
25. Inhibition of human immunodeficiency virus in vitro by combinations of 3′-azido-3′-deoxythymidine and foscarnet
26. Resistance of herpes simplex virus to 9-[2-hydroxyl-1-(hydroxymethyl)ethoxy]methyl guanine (2′NDG): physical mapping of drug synergism within the viral DNA polymerase locus
27. Treatment of acyclovir-resistant mucocutaneous herpes simplex infection in patients with acquired immunodeficiency syndrome
28. Mutants of herpes simplex virus type I and II that are resistant to phosphonoacetic acid induce altered DNA polymerase activities in infected cells
29. Related functional domains in herpes simplex DNA polymerase
30. Identification of amino acids in herpes simplex DNA polymerase involved in substrate and drug recognition
31. Site specific mutagenesis of the AIDS virus reverse transcriptase
32. Isolation and characterization of a dideoxyguanosine triphosphate-resistant mutant of human immunodeficiency virus reverse transcriptase
33. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro
34. A human cytomegalovirus mutant resistant to the nucleoside analog 9-{[2-hydroxy-1-hydroxymethyl/ethoxy]methyl} guanine (BW759U) induces reduced levels of BW759U triphosphate
35. Resistance of HCMV to DHPG HPMC and HPMPA mapped to the viral DNA polymerase gene
36. Inhibition of eucaryotic DNA polymerase by phosphonoacetate and phosphonoformate
37. Concentration-dependent effects of foscarnet on the cell cycle